Differences in glycosylation state of fibronectin from two rat colon carcinoma cell lines in relation to tumoral progressiveness.

abstract：:It has been hypothesized that rapidly dividing tumor cells can outpace adoptively transferred antitumor lymphocytes when tumors are large. However, this hypothesis is at odds with clinical observations indicating that bulky tumors can be destroyed by small numbers of adoptively transferred antitumor T cells. We sought...

journal_title：Cancer research

authors： Hwang LN,Yu Z,Palmer DC,Restifo NP

更新日期：2006-01-15 00:00:00

abstract：:The purpose of this study was to evaluate the efficacy of treatment with recombinant interleukin-2 (rIL-2) and lymphokine-activated killer cells in patients with advanced bladder cancer and to study the induced changes in the distribution of leukocyte subsets in blood and tumor. Nine patients with metastatic transitio...

journal_title：Cancer research

authors： Hermann GG,Geertsen PF,von der Maase H,Steven K,Andersen C,Hald T,Zeuthen J

更新日期：1992-02-01 00:00:00

abstract：:The lymphocytes from some Fanconi's anemia patients appeared to be more radiosensitive than normal as measured by the number of X-ray-(or bleomycin-) induced chromosome aberrations seen following G2 treatment. Fibroblasts from the same patients, however, all showed the same degree of colony survival as normals followi...

journal_title：Cancer research

authors： Duckworth-Rysiecki G,Taylor AM

更新日期：1985-01-01 00:00:00

abstract：:About 30% of all colorectal cancers are thought to have a genetic basis and the known predisposing genes can only account for a small fraction of cases. A previous report suggested that a colorectal cancer candidate gene, explaining at least 20% of colorectal cancer cases with family history, was located within a 25 c...

journal_title：Cancer research

authors： Kemp ZE,Carvajal-Carmona LG,Barclay E,Gorman M,Martin L,Wood W,Rowan A,Donohue C,Spain S,Jaeger E,Evans DG,Maher ER,Bishop T,Thomas H,Houlston R,Tomlinson I,Colorectal Tumour Gene Identification Study Consortium.

更新日期：2006-05-15 00:00:00

abstract：:The interaction between platelets and tumor cells is important in the formation of pulmonary metastasis. We previously established the 8F11 monoclonal antibody (mAb) by immunizing rats with the NL-17 cell line, a highly metastatic variant of mouse colon adenocarcinoma 26. 8F11 could inhibit the platelet aggregation in...

journal_title：Cancer research

authors： Kato Y,Fujita N,Yano H,Tsuruo T

更新日期：1997-07-15 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAID) are effective in suppressing the formation of colorectal tumors. However, the mechanisms underlying the antineoplastic effects of NSAIDs remain unclear. The effects of NSAIDs are incomplete, and resistance to NSAIDs is often developed. Growing evidence has indicated that th...

journal_title：Cancer research

authors： Bank A,Wang P,Du C,Yu J,Zhang L

更新日期：2008-01-01 00:00:00

abstract：:We developed a novel orthotopic mouse tumor model of renal cell carcinoma to collect and characterize cells spontaneously shed from SN12C (renal cell carcinoma) and SN12L1 (high metastatic variant of SN12C) tumors grown in kidneys of severe combined immunodeficient mice. Viability of the shed cell population was great...

journal_title：Cancer research

authors： Bockhorn M,Roberge S,Sousa C,Jain RK,Munn LL

更新日期：2004-04-01 00:00:00

abstract：:The role of the immune system in tumor elimination has been shown to be increasingly ambiguous, as many tumors not only escape recognition by the adaptive immune response but also even prime the immune cells to promote tumor growth. This effect is achieved through a number of mechanisms, which include both direct inte...

journal_title：Cancer research

authors： Kareva I,Hahnfeldt P

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to determine whether buccal mucosa would provide an alternate source of tissue for human biomonitoring. Samples of clinically normal oral biopsies were excised, and buccal mucosa were scraped or brushed from patients while they were undergoing surgery for the excision of intra-oral squamous c...

journal_title：Cancer research

authors： Stone JG,Jones NJ,McGregor AD,Waters R

更新日期：1995-03-15 00:00:00

abstract：:The olfactory marker protein (OMP) is a M(r) 19,000 polypeptide originally considered a selective marker for differentiated olfactory receptor neurons. In an attempt to induce neoplastic proliferation in the olfactory cells, we made mice transgenic for the simian virus 40 large T-antigen gene linked to the OMP gene pr...

journal_title：Cancer research

authors： Servenius B,Vernachio J,Price J,Andersson LC,Peterson PA

更新日期：1994-10-01 00:00:00

abstract：:Shorter alleles of a polymorphic [CAG](n) repeat in exon 1 of the androgen receptor (AR) have been associated with increased risk of prostate cancer and decreased risk of breast cancer. We prospectively assessed the association between the [CAG](n) repeat polymorphism in the androgen receptor and breast cancer risk am...

journal_title：Cancer research

authors： Haiman CA,Brown M,Hankinson SE,Spiegelman D,Colditz GA,Willett WC,Kantoff PW,Hunter DJ

更新日期：2002-02-15 00:00:00

abstract：:Between 5% and 10% of women who survive a first primary breast cancer will subsequently develop a second primary cancer in the contralateral breast. The Women's Environment, Cancer, and Radiation Epidemiology Study was designed to identify genetic and environmental determinants of contralateral breast cancer (CBC). In...

journal_title：Cancer research

authors： Concannon P,Haile RW,Børresen-Dale AL,Rosenstein BS,Gatti RA,Teraoka SN,Diep TA,Jansen L,Atencio DP,Langholz B,Capanu M,Liang X,Begg CB,Thomas DC,Bernstein L,Olsen JH,Malone KE,Lynch CF,Anton-Culver H,Bernstein JL,

更新日期：2008-08-15 00:00:00

abstract：:Preliminary results from a pilot trial on trastuzumab's mechanism of action against operable breast tumors overexpressing Her2 suggested a role for antibody-dependent cell cytotoxicity (ADCC). To examine factors affecting ADCC intensity and variability, we extended this study to the phenotypic and functional analysis ...

journal_title：Cancer research

authors： Varchetta S,Gibelli N,Oliviero B,Nardini E,Gennari R,Gatti G,Silva LS,Villani L,Tagliabue E,Ménard S,Costa A,Fagnoni FF

更新日期：2007-12-15 00:00:00

abstract：:Activation of the PI3K pathway occurs commonly in a wide variety of cancers. Experience with other successful targeted agents suggests that clinical resistance is likely to arise and may reduce the durability of clinical benefit. Here, we sought to understand mechanisms underlying resistance to PI3K inhibition in PTEN...

journal_title：Cancer research

authors： Nakanishi Y,Walter K,Spoerke JM,O'Brien C,Huw LY,Hampton GM,Lackner MR

更新日期：2016-03-01 00:00:00

abstract：:Peripheral blood myeloblasts from five patients with acute myeloblastic leukemia and peripheral remission leukocytes from two of these patients were radiolabeled by the lactoperoxidase-catalyzed surface radioiodination technique and incubated in a nutrient medium at 37 degrees. Radioactive materials shed from viable c...

journal_title：Cancer research

authors： Taub RN,Roncari DA,Baker MA

更新日期：1978-12-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD) could function as a cell surface sensor for cell density, controlling the transition between local cell proliferation and tissue invasion in melanoma progression. We have tested the hypothesis that progressive cell clustering controls the proteolytic cascad...

journal_title：Cancer research

authors： Lunter PC,van Kilsdonk JW,van Beek H,Cornelissen IM,Bergers M,Willems PH,van Muijen GN,Swart GW

更新日期：2005-10-01 00:00:00

abstract：:A HeLa cell line synchronized by double thymidine block and mitotic shake off was shown to have a characteristic surface morphology for each of the different cell cycle stages. Inhibitors of cell multiplication were used to arrest cells in specific cell cycle phases, and these cells had a surface morphology similar to...

journal_title：Cancer research

authors： Lundgren E,Roos G

更新日期：1976-11-01 00:00:00

abstract：:Nile blue derivatives have been shown to be potentially effective photosensitizers for photodynamic therapy of malignant tumors. Results of a previous study suggested that the high accumulation of these dyes in cells may be the result of dye aggregation, partition in membrane lipids, and/or sequestration in subcellula...

journal_title：Cancer research

authors： Lin CW,Shulok JR,Kirley SD,Cincotta L,Foley JW

更新日期：1991-05-15 00:00:00

abstract：:Inflammatory stimuli clearly contribute to lung cancer development and progression, but the underlying pathogenic mechanisms are not fully understood. We found that the proinflammatory cytokine IL-1β is dramatically elevated in the serum of patients with non-small cell lung cancer (NSCLC). In vitro studies showed that...

journal_title：Cancer research

authors： Wang L,Zhang LF,Wu J,Xu SJ,Xu YY,Li D,Lou JT,Liu MF

更新日期：2014-09-01 00:00:00

abstract：:Paclitaxel is a standard-of-care chemotherapy for breast cancer, despite the increasing recognition of its poor effectiveness in the treatment of patients with advanced disease. Here, we report that adenovirus-type 5 E1A-mediated elevation of the miRNA-processing enzyme Dicer is sufficient to enhance paclitaxel sensit...

journal_title：Cancer research

authors： Chang TY,Chen HA,Chiu CF,Chang YW,Kuo TC,Tseng PC,Wang W,Hung MC,Su JL

更新日期：2016-07-01 00:00:00

abstract：:The development of prophylactic cancer vaccines that protect healthy hosts from tumor development leaves open the question whether such vaccines are also effective against established tumors and metastases. We tested the therapeutic activity of a proven prophylactic anti-HER-2/neu vaccine against successive stages of ...

journal_title：Cancer research

authors： Nanni P,Nicoletti G,Palladini A,Croci S,Murgo A,Antognoli A,Landuzzi L,Fabbi M,Ferrini S,Musiani P,Iezzi M,De Giovanni C,Lollini PL

更新日期：2007-11-15 00:00:00

abstract：:Experimentally induced breast cancer is often preceded by the appearance of preneoplastic lesions which possess the attributes of hyperplastic normal tissue. These lesions can be isolated and carried as stably transplantable outgrowth lines which continue to morphologically resemble differentiating mammary tissue (Med...

journal_title：Cancer research

authors： Smith GH,Vonderhaar BK,Graham DE,Medina D

更新日期：1984-08-01 00:00:00

abstract：:To explore further the descriptive epidemiology of sarcomas of the uterus, we examined the distribution of marital status among 1479 white women diagnosed as having one of these tumors between January 1, 1973, and December 31, 1986, in 7 geographically defined areas of the United States. We estimated incidence rates b...

journal_title：Cancer research

authors： Schwartz SM,Weiss NS

更新日期：1990-03-15 00:00:00

abstract：:Mucinous colorectal cancers exhibit a characteristic set of molecular genetic alterations and may be derived from progenitor cells committed to the goblet cell lineage. Previously, we demonstrated that the MUC2 mucin gene promoter drives transgene reporter expression with high specificity in small intestinal goblet ce...

journal_title：Cancer research

authors： Gum JR Jr,Hicks JW,Gillespie AM,Rius JL,Treseler PA,Kogan SC,Carlson EJ,Epstein CJ,Kim YS

更新日期：2001-04-15 00:00:00

abstract：:Iodide uptake in the thyroid and breast is mediated by the sodium/iodide symporter (NIS). NIS activation is used for radioiodide imaging and therapeutic ablation of thyroid carcinoma. NIS is expressed in >70% of breast cancers but at a level insufficient for radioiodine treatment. All-trans retinoic acid (tRA) induces...

journal_title：Cancer research

authors： Ohashi E,Kogai T,Kagechika H,Brent GA

更新日期：2009-04-15 00:00:00

abstract：:A cell line derived from early passage of a transplantable tumor in athymic mice that initially had been injected with human breast adenocarcinoma cells produced a substantial amount of RNA sequences related to the Kirsten murine leukemia virus. The cell line derived from later passage of transplantation of these tumo...

journal_title：Cancer research

authors： Kuo MT,Sen S,Teeter L,Cailleau RM,Knesek JE,Bowen J

更新日期：1984-08-01 00:00:00

abstract：:Given the prevalence of Ras mutations in human cancer, it is critical to understand the effector pathways downstream of oncogenic Ras leading to transformation. To directly assess the requirement for Rac1 in K-ras-induced tumorigenesis, we employed a model of lung cancer in which an oncogenic allele of K-ras could be ...

journal_title：Cancer research

authors： Kissil JL,Walmsley MJ,Hanlon L,Haigis KM,Bender Kim CF,Sweet-Cordero A,Eckman MS,Tuveson DA,Capobianco AJ,Tybulewicz VL,Jacks T

更新日期：2007-09-01 00:00:00

abstract：:We have shown previously that hepatocyte growth factor (HGF), which is produced by lung fibroblasts, is a potent mitogen and motogen for both normal and neoplastic bronchial epithelium, and that expression of the HGF receptor, the c-met proto-oncogene protein, is uniformly found in the human bronchial epithelium and i...

journal_title：Cancer research

authors： Siegfried JM,Weissfeld LA,Singh-Kaw P,Weyant RJ,Testa JR,Landreneau RJ

更新日期：1997-02-01 00:00:00

abstract：:Werner syndrome (WRN) is an uncommon autosomal recessive disease in which progeroid features are associated with genetic instability and an elevated risk of neoplasia. We have used the glycophorin A (GPA) somatic cell mutation assay to analyze genetic instability in vivo in WRN patients and heterozygotes. GPA variant ...

journal_title：Cancer research

authors： Moser MJ,Bigbee WL,Grant SG,Emond MJ,Langlois RG,Jensen RH,Oshima J,Monnat RJ Jr

更新日期：2000-05-01 00:00:00

abstract：:The retinoblastoma (Rb)-E2F transcriptional regulatory pathway plays a major role in cell-cycle regulation, but its role in invasion and metastasis is less well understood. We find that many genes involved in the invasion of cancer cells, such as matrix metalloproteinases (MMP), have potential E2F-binding sites in the...

journal_title：Cancer research

authors： Johnson JL,Pillai S,Pernazza D,Sebti SM,Lawrence NJ,Chellappan SP

更新日期：2012-01-15 00:00:00