Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat.

abstract：:The FGFR1 gene transcript is alternatively processed to produce functionally different receptor forms. Previously, we identified a 69-nucleotide exonic splicing enhancer (ESE) required for alpha-exon inclusion in JEG3 cells. In the present study, we found that this sequence is composed of three independent elements, t...

journal_title：Cancer research

authors： Jin W,Cote GJ

更新日期：2004-12-15 00:00:00

abstract：:Previous results have suggested that methotrexate (MTX) could interfere with the repair of spontaneous DNA damage. To determine its effects on induced DNA damage, MTX was compared to hydroxyurea and arabinofuranosylcytosine (H/A), a drug combination known to block the DNA polymerase step of excision repair, for its ab...

journal_title：Cancer research

authors： Borchers AH,Kennedy KA,Straw JA

更新日期：1990-03-15 00:00:00

abstract：:In human breast carcinomas, increased copy number of DNA sequences derived from the long arm of chromosome 20 (20q) has been commonly observed by both chromosome microdissection and comparative genomic hybridization. This chromosomal region is likely to contain one or more genes that are the biological targets of this...

journal_title：Cancer research

authors： Guan XY,Xu J,Anzick SL,Zhang H,Trent JM,Meltzer PS

更新日期：1996-08-01 00:00:00

abstract：:Imatinib currently represents the standard treatment in the early chronic phase of chronic myelogenous leukemia (CML), thanks to the high percentage of cytogenetic complete remission achieved, but it is yet unclear to what extent it can eradicate leukemia. Therefore, different vaccination strategies have been suggeste...

journal_title：Cancer research

authors： Volpe G,Cignetti A,Panuzzo C,Kuka M,Vitaggio K,Brancaccio M,Perrone G,Rinaldi M,Prato G,Fava M,Geuna M,Pautasso M,Casnici C,Signori E,Tonon G,Tarone G,Marelli O,Fazio VM,Saglio G

更新日期：2007-06-01 00:00:00

abstract：:Benzo(a)pyrene and 210Po were administered both simultaneously and sequentially by intratracheal instillations to Syrian golden hamsters in experiments designed to identify any synergistic interactions between these carcinogens. Their effects were additive after simultaneous administration. A significant synergistic i...

journal_title：Cancer research

authors： Little JB,McGandy RB,Kennedy AR

更新日期：1978-07-01 00:00:00

abstract：:We studied the role of glycosphingolipids expressed on the cell surfaces of a metastatic tumor cell line. Glycosphingolipid compositions of the low-metastatic murine lymphosarcoma cell line RAW117-P and its sub-line, RAW117-H10, which shows higher metastatic potential for the liver than P cells, were compared. Both ty...

journal_title：Cancer research

authors： Taki T,Ishikawa D,Ogura M,Nakajima M,Handa S

更新日期：1997-05-15 00:00:00

abstract：:Rats were fed sodium saccharin as 5 or 7.5% of the diet by weight, and proliferation of the bladder epithelium was assessed by autoradiography, histology, and scanning electron microscopy. In Experiment 1, male F344 rats, 5 weeks old, were placed on a diet of 0, 5, or 7.5% NaS mixed in Prolab 3200, NIH-07, or AIN-76A ...

journal_title：Cancer research

authors： Garland EM,Sakata T,Fisher MJ,Masui T,Cohen SM

更新日期：1989-07-15 00:00:00

abstract：:Increased age is regularly linked with heightened cancer risk, but recent research suggests a flattening around age 80. We report that, independent of cancer site or time period, most incidence rates decrease in the more elderly and drop to or toward zero near the ceiling of human life span. For all major organ sites,...

journal_title：Cancer research

authors： Harding C,Pompei F,Lee EE,Wilson R

更新日期：2008-06-01 00:00:00

abstract：:Human cutaneous fatty acid-binding protein (C-FABP) gene is capable of inducing the metastatic phenotype when overexpressed in nonmetastatic rat Rama 37 cells. However, the mechanism of how it induces metastasis is not clear. Northern and slot blot analyses revealed that expression of the endogenous vascular endotheli...

journal_title：Cancer research

authors： Jing C,Beesley C,Foster CS,Chen H,Rudland PS,West DC,Fujii H,Smith PH,Ke Y

更新日期：2001-06-01 00:00:00

abstract：:Although ethanol has generally not been found to induce cancer in experimental animals, the consumption of alcoholic beverages has been linked to increased risks of several cancers in humans. Risks of oral, pharyngeal, laryngeal, esophageal, and liver cancer are elevated among drinkers, typically in proportion to the ...

journal_title：Cancer research

authors： Blot WJ

更新日期：1992-04-01 00:00:00

abstract：:Gemcitabine is currently the best treatment available for pancreatic cancer, but the disease develops resistance to the drug over time. Agents that can either enhance the effects of gemcitabine or overcome chemoresistance to the drug are needed for the treatment of pancreatic cancer. Curcumin, a component of turmeric ...

journal_title：Cancer research

authors： Kunnumakkara AB,Guha S,Krishnan S,Diagaradjane P,Gelovani J,Aggarwal BB

更新日期：2007-04-15 00:00:00

abstract：:Groups of 15 mice of three different laboratory strains (BALB/c, C3H/He, DBA/2) were fed on a low iron diet (5 mg iron/kg diet), and three similar groups of 15 mice were maintained on a normal iron diet (312 mg iron/kg diet). When the low iron diet group became iron deficient, tumor cells (5 x 10(5) cells/mouse) of CA...

journal_title：Cancer research

authors： Hann HW,Stahlhut MW,Blumberg BS

更新日期：1988-08-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) is etiologically linked to the endothelial tumor Kaposi's sarcoma and with two lymphoproliferatve disorders, primary effusion lymphoma and multicentric Castleman's disease. HHV-8 infects a variety of target cells both in vivo and in vitro, binds to the in vitro targ...

journal_title：Cancer research

authors： Naranatt PP,Krishnan HH,Svojanovsky SR,Bloomer C,Mathur S,Chandran B

更新日期：2004-01-01 00:00:00

abstract：:Identification of the molecular mechanism of action (MoA) of bioactive compounds is a crucial step for drug development but remains a challenging task despite recent advances in technology. In this study, we applied multidimensional proteomics, sensitivity correlation analysis, and transcriptomics to identify a common...

journal_title：Cancer research

authors： Peuget S,Zhu J,Sanz G,Singh M,Gaetani M,Chen X,Shi Y,Saei AA,Visnes T,Lindström MS,Rihani A,Moyano-Galceran L,Carlson JW,Hjerpe E,Joneborg U,Lehti K,Hartman J,Helleday T,Zubarev R,Selivanova G

更新日期：2020-04-01 00:00:00

abstract：:The possibility that neoplastic transformation may characteristically alter cell surface morphology prompted a comparison by scanning electron microscopy of nonneoplastic and tumorigenic cell lines from a single clone of mouse embryo cells. Among those studied by scanning electron microscopy, six lines of this clone p...

journal_title：Cancer research

authors： Wetzel B,Sanford KK,Fox CH,Jones GM,Westbrook EW,Tarone RE

更新日期：1977-03-01 00:00:00

abstract：:Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically hypoxic regions exhibit treatment resistance, more recently it has been shown that cycling hypoxic regions acquire prosurvival pathw...

journal_title：Cancer research

authors： Matsumoto S,Batra S,Saito K,Yasui H,Choudhuri R,Gadisetti C,Subramanian S,Devasahayam N,Munasinghe JP,Mitchell JB,Krishna MC

更新日期：2011-10-15 00:00:00

abstract：:We have measured the 31P nuclear magnetic resonance spectra of EMT6/Ro multicellular tumor spheroids over a wide range of sizes under constant nutrient conditions which matched those used for culturing the spheroids. The amount of nucleotide triphosphate per cell decreased with spheroid growth, roughly in proportion t...

journal_title：Cancer research

authors： Freyer JP,Schor PL,Jarrett KA,Neeman M,Sillerud LO

更新日期：1991-08-01 00:00:00

abstract：:Aromatase, an endomembrane-bound cytochrome P450, is the key enzyme of estrogen biosynthesis. Aromatase inhibitors, therefore, are clinically important tools in the treatment of estrogen-dependent tumor growth. To improve the specificity of these tools, inhibition at the nucleic acid level was examined. An antisense o...

journal_title：Cancer research

authors： Ackermann K,Fauss J,Pyerin W

更新日期：1994-09-15 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and PTEN mutations and the effect...

journal_title：Cancer research

authors： Stemke-Hale K,Gonzalez-Angulo AM,Lluch A,Neve RM,Kuo WL,Davies M,Carey M,Hu Z,Guan Y,Sahin A,Symmans WF,Pusztai L,Nolden LK,Horlings H,Berns K,Hung MC,van de Vijver MJ,Valero V,Gray JW,Bernards R,Mills GB,Hennes

更新日期：2008-08-01 00:00:00

abstract：:The major transmission route for Kaposi sarcoma-associated herpesvirus (KSHV) infection is the oral cavity through saliva. Kaposi sarcoma (KS) frequently occurs in the oral cavity in HIV-positive individuals and is often the first presenting sign of AIDS. However, the oral target cells for KSHV infection and the cellu...

journal_title：Cancer research

authors： Li Y,Zhong C,Liu D,Yu W,Chen W,Wang Y,Shi S,Yuan Y

更新日期：2018-01-01 00:00:00

abstract：:Phosphate ore mining and processing operations are associated with dusty conditions and potential exposure to gamma radiation and radon daughter products. Although most current measurements are within Occupational Safety and Health Administration (OSHA) guidelines, no measurements exist for the era preceding modern st...

journal_title：Cancer research

authors： Block G,Matanoski GM,Seltser R,Mitchell T

更新日期：1988-12-15 00:00:00

abstract：:The WWOX (WW domain containing oxidoreductase) gene was recently identified as a candidate tumor suppressor gene at 16q23.3-24.1, a chromosome region that spans the common fragile site FRA16D. To evaluate the potential role of the WWOX gene in esophageal squamous cell carcinomas, we examined 36 tumors for genetic alte...

journal_title：Cancer research

authors： Kuroki T,Trapasso F,Shiraishi T,Alder H,Mimori K,Mori M,Croce CM

更新日期：2002-04-15 00:00:00

abstract：:c-myc expression, amplification, and rearrangement were studied in neoplastic hepatic nodules of rats after diethylnitrosamine treatment, in hepatocellular carcinomas induced by N-methyl-N-nitrosourea, and in tumorigenic liver cell lines derived from rat hepatocytes transformed by diethylnitrosamine in vivo. Steady-st...

journal_title：Cancer research

authors： Suchy BK,Sarafoff M,Kerler R,Rabes HM

更新日期：1989-12-01 00:00:00

abstract：:We have isolated the full-length cDNA for human ATP-binding cassette, sub-family A, member 2 transporter (ABCA2). The ORF of this cDNA encodes a protein consisting of 2436 amino acids with apparent molecular weight of M(r) 270,000. Accordingly, ABCA2 is the largest known mammalian ABC transporter described thus far. A...

journal_title：Cancer research

authors： Vulevic B,Chen Z,Boyd JT,Davis W Jr,Walsh ES,Belinsky MG,Tew KD

更新日期：2001-04-15 00:00:00

abstract：:We have designed a novel peptide, DP1, which is able to mediate significant induction of apoptosis in solid tumors by local injection. This peptide, comprised of a protein transduction domain (PTD), PTD-5, fused to an antimicrobial peptide, (KLAKLAK)2, was able to trigger rapid apoptosis in a variety of cell lines in ...

journal_title：Cancer research

authors： Mai JC,Mi Z,Kim SH,Ng B,Robbins PD

更新日期：2001-11-01 00:00:00

abstract：:Treatment of rats with either intermittent bolus i.v. injections or continuous i.v. infusions of the same sublethal daily dose of tumor necrosis factor (TNF) results in decreased food intake and decreased nitrogen balance compared to saline-treated control rats. After 4 days of treatment, rats treated with intermitten...

journal_title：Cancer research

authors： Darling G,Fraker DL,Jensen JC,Gorschboth CM,Norton JA

更新日期：1990-07-01 00:00:00

abstract：:Osteoprotegerin (OPG), a novel, secreted tumor necrosis factor receptor family member that inhibits osteoclast formation and activity was examined for its activity in a syngeneic tumor model of humoral hypercalcemia of malignancy. Normal mice bearing Colon-26 tumors develop increases in both parathyroid hormone-relate...

journal_title：Cancer research

authors： Capparelli C,Kostenuik PJ,Morony S,Starnes C,Weimann B,Van G,Scully S,Qi M,Lacey DL,Dunstan CR

更新日期：2000-02-15 00:00:00

abstract：:Thirty-six wild-caught woodchucks (Marmota monax) were characterized according to sex, weight, trapping locality, liver pathology, and serum or hepatic markers of woodchuck hepatitis virus. Liver subcellular fractions were assayed for microsomal cytochromes P-450, aryl hydrocarbon hydroxylase, glutathione, cytosolic e...

journal_title：Cancer research

authors： De Flora S,Camoirano A,Romano M,Astengo M,Cesarone CF,Millman I

更新日期：1987-08-01 00:00:00

abstract：:XPC protein is a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency confers a predisposition to cancer. In this study, we show that XPC has a function that is independent of its canonical function in DNA repair, potentially altering the interpretation of how XPC deficienc...

journal_title：Cancer research

authors： Wang QE,Han C,Zhang B,Sabapathy K,Wani AA

更新日期：2012-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major adult liver cancers. The existence of combined hepatocellular-cholangiocarcinoma (CHC), a histopathologic intermediate form between HCC and CC, suggests phenotypic overlap between these tumors. Here, we applied an integrative oncogenomic approach...

journal_title：Cancer research

authors： Woo HG,Lee JH,Yoon JH,Kim CY,Lee HS,Jang JJ,Yi NJ,Suh KS,Lee KU,Park ES,Thorgeirsson SS,Kim YJ

更新日期：2010-04-15 00:00:00