Abstract：
:We have designed a novel peptide, DP1, which is able to mediate significant induction of apoptosis in solid tumors by local injection. This peptide, comprised of a protein transduction domain (PTD), PTD-5, fused to an antimicrobial peptide, (KLAKLAK)2, was able to trigger rapid apoptosis in a variety of cell lines in vitro, including MCA205 murine fibrosarcomas and human head and neck tumors. Furthermore, direct injection of DP1 into day 7 established MCA205 tumors in C57BL/6 mice resulted in the induction of tumor apoptosis and subsequent reduction in tumor volume. These results suggest that DP1 may be used clinically to treat accessible solid tumors or as an adjuvant therapy in conjunction with radiotherapy, standard chemotherapy, immunotherapy, or surgical debulking.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Mai JC,Mi Z,Kim SH,Ng B,Robbins PDsubject
Has Abstractpub_date
2001-11-01 00:00:00pages
7709-12issue
21eissn
0008-5472issn
1538-7445journal_volume
61pub_type
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