Aortic root dimensions are predominantly determined by genetic factors: a classical twin study.


OBJECTIVES:Previous studies using transthoracic echocardiography (TTE) observed moderate heritability of aortic root dimensions. Computed tomography angiography (CTA) might provide more accurate heritability estimates. Our primary aim was to assess the heritability of the aortic root with CTA. Our secondary aim was to derive TTE-based heritability and compare this with the CTA-based results. METHODS:In the BUDAPEST-GLOBAL study 198 twin subjects (118 monozygotic, 80 dizygotic; age 56.1 ± 9.4 years; 126 female) underwent CTA and TTE. We assessed the diameter of the left ventricular outflow tract (LVOT), annulus, sinus of Valsalva, sinotubular junction and ascending aorta. Heritability was assessed using ACDE model (A additive genetic, C common environmental, D dominant genetic, E unique environmental factors). RESULTS:Based on CTA, additive genetic effects were dominant (LVOT: A = 0.67, E = 0.33; annulus: A = 0.76, E = 0.24; sinus of Valsalva: A = 0.83, E = 0.17; sinotubular junction: A = 0.82, E = 0.18; ascending aorta: A = 0.75, E = 0.25). TTE-derived measurements showed moderate to no genetic influence (LVOT: A = 0.38, E = 0.62; annulus: C = 0.47, E = 0.53; sinus of Valsalva: C = 0.63, E = 0.37; sinotubular junction: C = 0.45, E = 0.55; ascending aorta: A = 0.67, E = 0.33). CONCLUSION:CTA-based assessment suggests that aortic root dimensions are predominantly determined by genetic factors. TTE-based measurements showed moderate to no genetic influence. The choice of measurement method has substantial impact on heritability estimates. KEY POINTS:• Aortic root dimensions are determined by genetic and environmental effects. • Transthoracic echocardiography (TTE) demonstrated moderate to no genetic effects on aortic root dimensions. • Computed tomography angiography might provide more accurate heritability estimates compared to TTE. • Three-dimensional imaging techniques are needed to reliably quantify aortic root dimensions.


Eur Radiol


European radiology


Celeng C,Kolossváry M,Kovács A,Molnár AÁ,Szilveszter B,Horváth T,Károlyi M,Jermendy ÁL,Tárnoki ÁD,Tárnoki DL,Karády J,Voros S,Jermendy G,Merkely B,Maurovich-Horvat P




Has Abstract


2017-06-01 00:00:00














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    journal_title:European radiology

    pub_type: 杂志文章


    authors: González DR,Carpenter T,van Hemert JI,Wardlaw J

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    journal_title:European radiology

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    authors: Kluza E,Kleijnen JP,Martens MH,Rennspiess D,Maas M,Jeukens CR,Riedl RG,zur Hausen A,Beets GL,Beets-Tan RG

    更新日期:2016-05-01 00:00:00

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    journal_title:European radiology

    pub_type: 杂志文章,评审


    authors: Baur A,Dietrich O,Reiser M

    更新日期:2003-07-01 00:00:00

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    abstract:OBJECTIVE:To test the feasibility of fat-selective GRE imaging using a spectral-spatial excitation technique for determination of intrahepatic lipid content (IHL) in obese adolescents. METHODS:Fat-selective MR imaging (1.5 T) was applied to record a single axial slice through a representative liver region within a sin...

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    pub_type: 杂志文章


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    journal_title:European radiology

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    authors: Higaki A,Ito K,Tamada T,Sone T,Kanki A,Noda Y,Yasokawa K,Yamamoto A

    更新日期:2014-10-01 00:00:00

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    journal_title:European radiology

    pub_type: 杂志文章


    authors: Hegenscheid K,Seipel R,Schmidt CO,Völzke H,Kühn JP,Biffar R,Kroemer HK,Hosten N,Puls R

    更新日期:2013-03-01 00:00:00

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    更新日期:2018-05-01 00:00:00

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    更新日期:2019-07-01 00:00:00

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    authors: Vanhoenacker F,Morlion J,De Schepper AM,Callewaert E

    更新日期:1999-01-01 00:00:00

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    journal_title:European radiology

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    authors: Mueller-Lisse UG,Murer S,Mueller-Lisse UL,Kuhn M,Scheidler J,Scherr M

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    authors: Lee H,Kim SY,Lee SJ,Kim JK,Reddy RP,Schoepf UJ

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    authors: Massez A,Rypens F,Metens T,Donner C,Avni FE

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    journal_title:European radiology

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    authors: Nakanishi K,Araki N,Yoshikawa H,Hashimoto T,Nakamura H

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    authors: Ambrosetti P,Becker C,Terrier F

    更新日期:2002-05-01 00:00:00

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    authors: Vitak B

    更新日期:1998-01-01 00:00:00

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    authors: Doherty P,O'Leary D,Brennan PC

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    authors: Maroldi R,Battaglia G,Nicolai P,Maculotti P,Cappiello J,Cabassa P,Farina D,Chiesa A

    更新日期:1997-01-01 00:00:00

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    authors: Bezzi M,Spinelli A,Pierleoni M,Andreoli G

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    更新日期:2020-05-01 00:00:00