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Automated computer-based CT stratification as a predictor of outcome in hypersensitivity pneumonitis.

Abstract：

BACKGROUND:Hypersensitivity pneumonitis (HP) has a variable clinical course. Modelling of quantitative CALIPER-derived CT data can identify distinct disease phenotypes. Mortality prediction using CALIPER analysis was compared to the interstitial lung disease gender, age, physiology (ILD-GAP) outcome model. METHODS:CALIPER CT analysis of parenchymal patterns in 98 consecutive HP patients was compared to visual CT scoring by two radiologists. Functional indices including forced vital capacity (FVC) and diffusion capacity for carbon monoxide (DLco) in univariate and multivariate Cox mortality models. Automated stratification of CALIPER scores was evaluated against outcome models. RESULTS:Univariate predictors of mortality included visual and CALIPER CT fibrotic patterns, and all functional indices. Multivariate analyses identified only two independent predictors of mortality: CALIPER reticular pattern (p = 0.001) and DLco (p < 0.0001). Automated stratification distinguished three distinct HP groups (log-rank test p < 0.0001). Substitution of automated stratified groups for FVC and DLco in the ILD-GAP model demonstrated no loss of model strength (C-Index = 0.73 for both models). Model strength improved when automated stratified groups were combined with the ILD-GAP model (C-Index = 0.77). CONCLUSIONS:CALIPER-derived variables are the strongest CT predictors of mortality in HP. Automated CT stratification is equivalent to functional indices in the ILD-GAP model for predicting outcome in HP. KEY POINTS:• Computer CT analysis better predicts mortality than visual CT analysis in HP. • Quantitative CT analysis is equivalent to functional indices for prognostication in HP. • Prognostication using the ILD-GAP model improves when combined with quantitative CT analysis.

journal_name

Eur Radiol

journal_title

European radiology

authors

Jacob J,Bartholmai BJ,Rajagopalan S,Karwoski R,Mak SM,Mok W,Della Casa G,Sugino K,Walsh SLF,Wells AU,Hansell DM

doi

10.1007/s00330-016-4697-4

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

3635-3646

issue

eissn

0938-7994

issn

1432-1084

pii

10.1007/s00330-016-4697-4

journal_volume

pub_type

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Automated computer-based CT stratification as a predictor of outcome in hypersensitivity pneumonitis.