The impact of dietary fat and fiber on intestinal carcinogenesis.

Abstract:

:The effect of dietary fiber on intestinal carcinogenesis in animals is controversial. Some find that the addition of wheat bran or cellulose inhibits intestinal cancer in rats, while others report no effect. Such mixed results often are due to differences in the design of experiments. One important aspect in this regard is the amount of fat in the diet. Some fiber supplements inhibit cancer formation when the fat content is normal but not when it is high. However, a recent epidemiological study in Scandinavia showed a lower cancer incidence in a rural population compared with an urban area, in spite of the fact that the dietary fat content was high in both regions. There was a modest difference in the amount of fiber, and this may not have accounted completely for the variation in cancer incidence. Other dietary factors might have added inhibitory response to help overcome the promotional effect of an excessive amount of fat. The interaction among dietary components must be considered when designing animal experiments to assess the effect of fiber on cancer development.

journal_name

Prev Med

journal_title

Preventive medicine

authors

Nigro ND,Bull AW

doi

10.1016/0091-7435(87)90071-5

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

554-8

issue

4

eissn

0091-7435

issn

1096-0260

pii

0091-7435(87)90071-5

journal_volume

16

pub_type

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