Abstract:
:Oral baclofen has long been a mainstay in the management of spasticity. This review looks at the clinical evidence for the efficacy and safety of oral baclofen in patients with spasticity of any origin or severity, to determine whether there is a rationale for the use of intrathecal baclofen. Results suggest that oral baclofen may be effective in many patients with spasticity, regardless of the underlying disease or severity, and that it is at least comparable with other antispasmodic agents. However, adverse effects, such as muscle weakness, nausea, somnolence and paraesthesia, are common with oral baclofen, affecting between 25% and 75% of patients, and limiting its usefulness. Intrathecal baclofen may be an effective alternative as the drug is delivered directly into the cerebrospinal fluid, thus bypassing the blood-brain barrier and thereby optimizing the efficacy of baclofen while minimizing drug-related side-effects. Intrathecal baclofen is a viable option in patients who experience intolerable side-effects or who fail to respond to the maximum recommended dose of oral baclofen.
journal_name
J Rehabil Medjournal_title
Journal of rehabilitation medicineauthors
Ertzgaard P,Campo C,Calabrese Adoi
10.2340/16501977-2211subject
Has Abstractpub_date
2017-03-06 00:00:00pages
193-203issue
3eissn
1650-1977issn
1651-2081journal_volume
49pub_type
杂志文章,评审abstract:OBJECTIVE:To build a new activity-based, "bed to community", aetiology-independent measure of balance within the neurological rehabilitation setting by merging some existing scales. METHODS:Balance scales were selected using a conceptual framework and subsequently administered to a convenience sample of adult patients...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0797
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To investigate the long-term efficacy of neuromuscular electrical stimulation in enhancing motor recovery in the upper extremities of stroke patients. METHODS:A total of 46 patients with stroke were assigned to a neuromuscular electrical stimulation group or a control group. All patients received a standard ...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章,随机对照试验
doi:10.2340/16501977-0807
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:Assess the effects of daily neuroprosthetic (NESS Handmaster) functional electrical stimulation in sub-acute stroke. DESIGN:Controlled study, patients clinically stratified to 2 groups; no active finger movement, and partial active finger movements, and then randomized to control and neuroprosthesis groups. ...
journal_title:Journal of rehabilitation medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/16501970410035387
更新日期:2005-01-01 00:00:00
abstract::According to Antonovsky, the individual's sense of coherence is assumed to be crucial in coping with stressful life events. The purpose of this study was to investigate the associations between the sense of coherence of the spouses of stroke victims, the objective severity of the stroke and the spouses' perception of ...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.1080/165019702753714156
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:We tested the hypothesis that physically active people with spinal cord injury do not have increased subclinical atherosclerosis compared with an age-matched able-bodied group. METHODS:Subjects comprised 28 wheelchair athletes with spinal cord injury (mean age 22 (standard deviation (SD) 3) years) and 24 rec...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0212
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To study the influence of physical impairments on hip bone mineral density in women with Parkinson's disease. DESIGN:Cross-sectional study. SUBJECTS/PATIENTS:Thirty-four women with Parkinson's disease and 30 age-matched healthy controls. METHODS:Patients with Parkinson's disease underwent a hip scan using ...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0311
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:This study compares functional status, quality of life and community integration in 2008 Sichuan earthquake survivors with spinal cord injury at hospital discharge and at 1-year follow-up in the community. METHODS:Twenty-six subjects with spinal cord injury completed demographic and medical questionnaires an...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0944
更新日期:2012-03-01 00:00:00
abstract::This consensus paper is derived from a meeting of an international group of 19 neurological rehabilitation specialists with a combined experience of more than 250 years (range 4-25 years; mean 14.1 years) in treating post-stroke spasticity with botulinum toxin A. The group undertook critical assessments of some recurr...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-2753
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:Lack of sensory feedback is a drawback in today's hand prostheses. We present here a non-invasive simple sensory feedback system, which provides the user of a prosthetic hand with sensory feedback on the arm stump. It is mediated by air in a closed loop system connecting silicone pads on the prosthetic hand w...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-1001
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To investigate the activity of proprioceptive systems during early recovery of motor function after ischaemic stroke in a prospective, longitudinal, functional imaging study. METHODS:Ten patients with unilateral infarction of the posterior internal capsule were investigated using oxygen-15-water positron emi...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0089
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To explore the occurrence of, and risk factors for, spasticity until 6 months after first-ever stroke. METHODS:Forty-nine patients were examined at day 2-10, at 1 month, and at 6 months. The modified Ashworth Scale was used to assess resistance to passive movements. A comprehensive clinical examination was p...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0509
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To examine restrictions in daily functioning from a rehabilitation perspective in patients one year after discharge from the intensive care unit, and to identify prognostic factors for functional status. DESIGN:Cross-sectional design. PATIENTS:Consecutive patients who were admitted to the intensive care uni...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0333
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To report on the results of the consensus process integrating evidence from preliminary studies to develop the first version of a Comprehensive ICF Core Set and a Brief ICF Core Set for chronic widespread pain. METHODS:A formal decision-making and consensus process integrating evidence gathered from prelimin...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.1080/16501960410016046
更新日期:2004-07-01 00:00:00
abstract::Satisfaction with life as a whole and with 10 domains of life was assessed in a nationally representative Swedish sample of 1207 women and 1326 men aged between 18 and 64 years, using a generic self-report checklist (LiSat-11), with levels of satisfaction ranging along a six-grade ordinal scale from 1 (very dissatisfi...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.1080/165019702760279242
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To establish the discriminatory items of the clinical examination of non-specific low back pain, important to physiotherapists. DESIGN:A focus group and Delphi technique with UK physiotherapists. SUBJECTS:A purposive sample of 30 physiotherapists attended a focus group and completed 3 rounds of Delphi quest...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.1080/16501970600632768
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To evaluate sexual function amongst adult individuals with spina bifida and to register their subjective satisfaction with their sexual life and relationships. SETTING:Department for Spinal Cord Injuries, East Denmark. STUDY DESIGN AND METHODS:Cohort study. Medical record information, neurological examinati...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-1863
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Shortly after stroke, patients exhibit excessive sensitivity to visual, proprioceptive and vestibular perturbations regarding balance control. OBJECTIVE:To evaluate the stability of this perceptual behaviour after stroke and test the relationships between sensory sensitivity and balance. METHODS:Thirty sub...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-1968
更新日期:2015-06-01 00:00:00
abstract::is missing (Letter to the Editor). ...
journal_title:Journal of rehabilitation medicine
pub_type: 信件
doi:10.2340/16501977-2092
更新日期:2017-01-19 00:00:00
abstract:OBJECTIVE:To explore long-term effects on unilateral spatial neglect of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the unaffected posterior parietal cortex. DESIGN:Uncontrolled pilot study. SUBJECTS:Two chronic-phase patients with left-sided unilateral spatial neglect from cerebral infarct...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.1080/16501970500441807
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To assess foot pain and its correlation with walking ability in diabetic patients. SUBJECTS:Two groups of type 2 diabetic patients (30 with symptomatic neuropathy and 30 without symptomatic neuropathy) and 30 healthy volunteers were studied. METHODS:Pain was assessed by the pain sub-scale of the Foot Functi...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.1080/16501970410029816
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To determine reliability of maximal grip strength, muscle coordination and muscle endurance. To compare these parameters in young adults with unilateral cerebral palsy and healthy subjects. To evaluate the correlation of these variables with functional activities. SUBJECTS:Twenty-six healthy subjects and 26 ...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0095
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To assess the associations between psychological factors and return to work among long-term sickness absentees. DESIGN:Longitudinal study with a 3-year follow-up. SUBJECTS:Long-term sickness absentees (n = 905) who had undergone a multidisciplinary medical assessment. METHODS:Three years after multidiscipl...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-1077
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To describe problematic aspects of faecal incontinence according to the experience of adults with spina bifida. DESIGN:Qualitative interview study. SUBJECTS:Eleven adults with spina bifida and bowel problems. METHOD:Semi-structured open-ended interviews and qualitative analysis. RESULTS:Problematic aspect...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0373
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To assess cardiorespiratory fitness in patients following an aneurysmal subarachnoid haemorrhage and to explore this in fatigued and non-fatigued patients. DESIGN:Cross-sectional case-control study. SUBJECTS/PATIENTS:A total of 28 patients, 6 months post aneurysmal subarachnoid haemorrhage, and 28 sex- and ...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-2127
更新日期:2016-10-12 00:00:00
abstract:OBJECTIVE:To investigate the co-ordination between reaching, ground reaction forces and muscle activity in standing children with severe spastic diplegia wearing dynamic ankle-foot orthoses compared with typically developing children. DESIGN:Clinical experimental study. SUBJECTS:Six children with spastic diplegia (Gr...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0121
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of individualized manual physiotherapy and exercises compared with individualized exercises alone in patients with shoulder impingement syndrome. DESIGN:Randomized controlled trial. SUBJECTS:Patients with shoulder impingement of more than 4 weeks' duration. METHODS:Patients in the...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章,随机对照试验
doi:10.2340/16501977-1142
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To examine the construct and rating scale of the Assessment of Capacity for Myoelectric Control, an assessment to evaluate ability in using a prosthetic hand. DESIGN:Cross-sectional study. SUBJECTS:Upper limb prosthesis users with different prosthetic levels/sides and prosthetic experience were included (n ...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-0361
更新日期:2009-05-01 00:00:00
abstract::It is now widely recognized that the cerebral cortex of adult human and non-human mammals is capable of widespread functional and structural plasticity. During the learning of new skills, cortical regions associated with sensorimotor function of the body parts most utilized for the skilled task come to be represented ...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1080/16501960310010070
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To develop the Rehabilitation Patient Experiences Questionnaire for patients undergoing rehabilitation for rheumatological disorders. METHODS:Development of the instrument was based on literature review and adaptation of the Patient Experiences Questionnaire. The instrument was piloted and then administered ...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章,多中心研究
doi:10.2340/16501977-0375
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To explore patient experiences of participating in multimodal pain rehabilitation in primary care. SUBJECTS:Twelve former patients (7 women and 5 men) in multimodal rehabilitation in primary care were interviewed about their experiences of multimodal rehabilitation. METHODS:The interviews were analysed usin...
journal_title:Journal of rehabilitation medicine
pub_type: 杂志文章
doi:10.2340/16501977-2286
更新日期:2018-01-10 00:00:00