Long-term effect of low-frequency repetitive transcranial magnetic stimulation over the unaffected posterior parietal cortex in patients with unilateral spatial neglect.

Abstract:

OBJECTIVE:To explore long-term effects on unilateral spatial neglect of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the unaffected posterior parietal cortex. DESIGN:Uncontrolled pilot study. SUBJECTS:Two chronic-phase patients with left-sided unilateral spatial neglect from cerebral infarction. METHODS:Six rTMS sessions were undertaken for 2 weeks. Each session included 900 stimuli applied over P5 at an intensity of 95% motor thresholds and a frequency of 0.9 Hz. The Behavioural Inattention Test, either the Mini-Mental State Examination or the Revised Hasegawa Dementia Scale, Brunnstrom Recovery Stage, and Barthel Index were evaluated at 2-week intervals until 6 weeks after rTMS sessions. Single-photon emission computed tomography was performed 2 weeks before and after rTMS. RESULTS:Behavioural Inattention Test scores improved remarkably, especially from 2 to 4 weeks after rTMS sessions. At 6 weeks, Behavioural Inattention Test scores still remained above pre-rTMS levels. Other clinical evaluations as well as single-photon emission computed tomography showed no significant change during the study. CONCLUSION:In this small pilot study, low-frequency rTMS over the unaffected posterior parietal cortex decreased unilateral spatial neglect for at least 6 weeks.

journal_name

J Rehabil Med

authors

Shindo K,Sugiyama K,Huabao L,Nishijima K,Kondo T,Izumi S

doi

10.1080/16501970500441807

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

65-7

issue

1

eissn

1650-1977

issn

1651-2081

journal_volume

38

pub_type

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