Abstract:
:Unsaturated cobalamin-binding capacity in plasma (P-UBBC) is determined by use of a silica gel (QUSO G32) to separate haptocorrin (P-ApoHC) and transcobalamin (P-ApoTC). The method is sensitive and precise: detection limit 13 pmol/L, interassay coefficients of variation 3% for P-UBBC (mean = 1080 pmol/L), 4% for P-ApoTC (mean = 700 pmol/L) (n = 30). Values for P-UBBC, P-ApoHC, P-ApoTC, and P-TBBC (P-UBBC plus P-cobalamin) determined in a population study of 228 individuals, ages 21-87 years, did not differ by sex. These values increased with age, whereas the cobalamin saturation (P-cobalamin as percentage of P-TBBC) decreased with age. However, these changes were statistically significant but marginal and thus not clinically important. We therefore suggest using combined reference intervals (central 95 percentiles) for all age groups: 500-1200 pmol/L for P-UBBC, 90-275 pmol/L for P-ApoHC, 400-930 pmol/L for P-ApoTC, 850-1600 pmol/L for P-TBBC, and 20-50% for cobalamin saturation. Results for 277 inpatients show high P-ApoHC in myeloproliferative disorders or acute nonlymphatic leukemia, whereas P-ApoTC concentrations are high in some patients with lymphoproliferative disorders or autoimmune diseases.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Gimsing P,Nexø Esubject
Has Abstractpub_date
1989-07-01 00:00:00pages
1447-51issue
7eissn
0009-9147issn
1530-8561journal_volume
35pub_type
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journal_title:Clinical chemistry
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journal_title:Clinical chemistry
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journal_title:Clinical chemistry
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journal_title:Clinical chemistry
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journal_title:Clinical chemistry
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
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journal_title:Clinical chemistry
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journal_title:Clinical chemistry
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更新日期:1989-10-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1990-09-01 00:00:00
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doi:
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doi:
更新日期:1992-09-01 00:00:00
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doi:
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journal_title:Clinical chemistry
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doi:
更新日期:1992-09-01 00:00:00
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journal_title:Clinical chemistry
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doi:
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journal_title:Clinical chemistry
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doi:
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journal_title:Clinical chemistry
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doi:
更新日期:2002-02-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1981-10-01 00:00:00
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journal_title:Clinical chemistry
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