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Changes over Time and Responsiveness of the Cochin Hand Function Scale and Mouth Handicap in Systemic Sclerosis Scale in Patients with Systemic Sclerosis: A Prospective Observational Study.

Abstract：

OBJECTIVE:To assess changes over time and responsiveness of the Cochin Hand Function Scale (CHFS) and Mouth Handicap In Systemic Sclerosis (MHISS) scale in patients with systemic sclerosis (SSc). DESIGN:This was a prospective longitudinal study. PARTICIPANTS:Participants were drawn from a convenience sample of individuals with SSc, who were attending the annual Congress of the Association des Sclérodermiques de France, the French SSc patients' association. METHODS:Participants were evaluated twice by the CHFS, MHISS scale, Health Assessment Questionnaire, McMaster-Toronto Arthritis Patient Preference Disability Questionnaire, and other outcome measures. Differences in measures over time were evaluated using the Wilcoxon signed rank test. Responsiveness was assessed by the effect size and standardized response mean. Nonparametric Spearman rank correlation (r) was used to assess correlation between outcome measures. RESULTS:Forty-nine patients were assessed. The CHFS and MHISS scores worsened over time (mean [SD] differences 2.7 [10.7], P = 0.08, and 3.5 [9.8], P = 0.14, respectively). The CHFS effect size and standardized response mean values were -0.16 and -0.24, respectively, and MHISS values were -0.53 and -0.52, respectively. The correlation between change in the CHFS score and change in Health Assessment Questionnaire and McMaster-Toronto Arthritis Patient Preference Disability Questionnaire scores was fair to moderate, whereas changes in MHISS score were poorly or not correlated to other measures. For patients considering their state deteriorated, the MHISS scale was the most responsive instrument. CONCLUSIONS:The CHFS and MHISS scores may be useful in detecting changes in location-specific limitations in activity for SSc patients.

journal_name

Am J Phys Med Rehabil

journal_title

American journal of physical medicine & rehabilitation

authors

Nguyen C,Bérezné A,Mestre-Stanislas C,Lefèvre-Colau MM,Rannou F,Guillevin L,Mouthon L,Poiraudeau S

doi

10.1097/PHM.0000000000000611

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

e189-e197

issue

eissn

0894-9115

issn

1537-7385

journal_volume

pub_type

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Changes over Time and Responsiveness of the Cochin Hand Function Scale and Mouth Handicap in Systemic Sclerosis Scale in Patients with Systemic Sclerosis: A Prospective Observational Study.