Abstract:
PURPOSE:The purpose of this narrative review is to provide practical and useful guidance for clinicians considering the use of intravenous ketamine for its analgosedative properties in adult, critically ill patients. METHODS:MEDLINE was searched from inception until January 2016. Articles related to the pharmacological properties of ketamine were retrieved. Information pertaining to pharmacology, pharmacokinetics, dosing regimens, adverse effects, and outcomes was obtained from relevant studies. RESULTS:Although the primary mechanism for ketamine's pharmacological effects is N-methyl-d-aspartate blockade, there are several potential mechanisms of action. It has a very large volume of distribution due to its lipophilicity, which can lead to drug accumulation with sustained infusions. Ketamine has several advantages compared with conventional sedatives such as preserving pharyngeal and laryngeal protective reflexes, lowering airway resistance, increasing lung compliance, and being less likely to produce respiratory depression. It causes sympathetic stimulation, which is also unlike other sedatives and analgesics. There are psychotomimetic effects, which are a concern in terms of delirium. Dosing and monitoring recommendations are provided. CONCLUSIONS:Ketamine has a unique pharmacological profile compared with more traditional agents such as opioids, which makes it an appealing alternative agent for analgosedation in the intensive care unit setting.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Erstad BL,Patanwala AEdoi
10.1016/j.jcrc.2016.05.016subject
Has Abstractpub_date
2016-10-01 00:00:00pages
145-9eissn
0883-9441issn
1557-8615pii
S0883-9441(16)30088-0journal_volume
35pub_type
杂志文章,评审abstract:OBJECTIVE:To describe the associations between right ventricular (RV) function and outcomes of patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). METHODS:This is a retrospective study, conducted 2006-2015 at an academic hospital in USA. We included patients with AKI requirin...
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journal_title:Journal of critical care
pub_type: 临床试验,杂志文章
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journal_title:Journal of critical care
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journal_title:Journal of critical care
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2011.12.008
更新日期:2012-10-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2017.03.025
更新日期:2017-08-01 00:00:00
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journal_title:Journal of critical care
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pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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journal_title:Journal of critical care
pub_type: 临床试验,杂志文章
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journal_title:Journal of critical care
pub_type: 杂志文章
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journal_title:Journal of critical care
pub_type: 杂志文章,多中心研究
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2012.06.012
更新日期:2013-04-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2017.11.014
更新日期:2018-04-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2006.03.012
更新日期:2006-09-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcrc.2017.04.023
更新日期:2017-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2017.08.017
更新日期:2017-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2010.10.014
更新日期:2011-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2012.12.013
更新日期:2013-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00