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Endothelial glycocalyx biomarkers increase in patients with infection during Emergency Department treatment.

Abstract：

PURPOSE:Endothelial glycocalyx (EG) shedding may promote organ failure in sepsis. This study describes temporal changes in EG biomarkers from Emergency Department (ED) arrival, and associations with clinical characteristics. MATERIALS AND METHODS:This prospective observational study included 23 patients with simple infection, 86 with sepsis and 29 healthy controls. Serum EG biomarkers included syndecan-1, syndecan-4 and hyaluronan. Samples were taken on enrolment in the ED (T0), 1 hour (T1), 3 hours (T3) and 12 to 24 hours (T24) later. RESULTS:Syndecan-1 concentration increased incrementally over time (T0-T24, both patient groups, P < .001) whereas hyaluronan concentration peaked at T3 (T0-T3, sepsis group, P < .001). Hyaluronan was positively associated with cumulative fluid volumes (P < .001) at T0, T1, and T3, independent of illness severity. Both syndecan-1 (OR 1.04, 95% CI 1.01-1.07, P = .017) and hyaluronan (OR 1.83, 95% CI 1.46-2.30, P < .001) were associated with organ failure, independent of age and comorbidity. Syndecan-4 concentration was not different between groups or over time. CONCLUSIONS:In contrast to previous ICU studies, EG biomarkers increased during the first 24 hours of sepsis treatment and were associated with fluid volumes and organ failure. Further investigation is required to determine if interventions delivered in the ED contribute to EG shedding.

journal_name

J Crit Care

journal_title

Journal of critical care

authors

Smart L,Macdonald SPJ,Burrows S,Bosio E,Arendts G,Fatovich DM

doi

10.1016/j.jcrc.2017.07.001

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

304-309

eissn

0883-9441

issn

1557-8615

pii

S0883-9441(17)30555-5

journal_volume

42

pub_type

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