Abstract：
OBJECTIVE:To describe the associations between right ventricular (RV) function and outcomes of patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). METHODS:This is a retrospective study, conducted 2006-2015 at an academic hospital in USA. We included patients with AKI requiring CRRT who had paired echocardiograms within 2 weeks before and after CRRT initiation. We defined improvement in RV systolic function as 2-point improvement on the semiquantitative scale. RESULTS:The cohort included 201 patients. The mean(±SD) age was 59(±16) years with 83(41%) female. The median time of the pre and post echocardiograms relative to CRRT initiation were - 1 day (IQR-3;0) prior to and 3 days (IQR1;7) after CRRT initiation. Thirty-one (15%) patients showed an improvement in their RV function. Using a multivariable logistic regression model, improvement in RV systolic function was associated with lower odds of major adverse kidney events (composite of mortality, need for dialysis or persistently elevated serum creatinine) at 90 days with odds ratio (OR) of 0.37(95%CI:0.17-0.84, p.016). Positive cumulative fluid balance was associated with lower odds of improvement in RV function (OR 0.95 per 1-l increase, p 0.045). CONCLUSION:Serial assessment of RV function among patients with AKI requiring CRRT could provide prognostic value.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Shawwa K,Kompotiatis P,Wiley BM,Jentzer JC,Kashani KBdoi
10.1016/j.jcrc.2020.11.022subject
Has Abstractpub_date
2020-11-30 00:00:00pages
82-87eissn
0883-9441issn
1557-8615pii
S0883-9441(20)30786-3journal_volume
62pub_type
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