Abstract:
PURPOSE:This study investigated the feasibility of high-flow nasal cannula (HFNC) oxygen therapy for acute respiratory failure in adult patients with hematologic malignancies. MATERIALS AND METHODS:We identified 45 acute respiratory failure patients with hematologic malignancies who received HFNC therapy between March 2012 and June 2014 at Seoul St Mary's Hospital. Their medical records were reviewed retrospectively to identify useful prognostic factors for successful treatment. RESULTS:Of the 45 patients, 15 (33.3%) successfully recovered, and 30 were changed to invasive ventilation due to failed HFNC treatment. The etiologies of acute respiratory failure were bacterial pneumonia (57.8%), Pneumocystis jirovecii pneumonia (17.8%), pulmonary edema (8.9%), and bronchiolitis obliterans organizing pneumonia (8.9%). The overall mortality rate was 62.2%. The HFNC treatment success rate was significantly different between the survivors and nonsurvivors. To evaluate risk factors for HFNC treatment failure, differences between the HFNC treatment success and failure groups were compared. There were no significant differences in the severity of underlying medical conditions. The percentage of bacterial pneumonia was significantly higher in the HFNC treatment failure group compared with the success group (73.3% vs 26.7%; P = .004). CONCLUSIONS:High-flow nasal cannula offers an interesting alternative to invasive ventilation in acute respiratory failure patients with hematologic malignancies. However, attention must be paid to the appropriate choice of HFNC settings such as oxygen flow.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Lee HY,Rhee CK,Lee JWdoi
10.1016/j.jcrc.2015.03.014subject
Has Abstractpub_date
2015-08-01 00:00:00pages
773-7issue
4eissn
0883-9441issn
1557-8615pii
S0883-9441(15)00114-8journal_volume
30pub_type
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pub_type: 杂志文章
doi:10.1016/j.jcrc.2014.04.013
更新日期:2014-08-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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更新日期:2017-04-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:1998-06-01 00:00:00
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journal_title:Journal of critical care
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2014.07.001
更新日期:2014-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-03-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,评审
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更新日期:1995-09-01 00:00:00
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更新日期:2017-06-01 00:00:00
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journal_title:Journal of critical care
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更新日期:2017-02-01 00:00:00
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