Abstract：
PURPOSE:COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19. METHODS:PubMed, EMBASE, and three trial Registries were searched for studies on the use of chloroquine in patients with COVID-19. RESULTS:We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. Chloroquine seems to be effective in limiting the replication of SARS-CoV-2 (virus causing COVID-19) in vitro. CONCLUSIONS:There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. Safety data and data from high-quality clinical trials are urgently needed.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Cortegiani A,Ingoglia G,Ippolito M,Giarratano A,Einav Sdoi
10.1016/j.jcrc.2020.03.005subject
Has Abstractpub_date
2020-06-01 00:00:00pages
279-283eissn
0883-9441issn
1557-8615pii
S0883-9441(20)30390-7journal_volume
57pub_type
杂志文章abstract：:Sixty-nine patients undergoing liver transplantation were evaluated to elucidate the relationship between hypotension and physiological changes seen on reperfusion of the grafted liver. Measured variables included hemodynamic profiles, core temperature, serum potassium, ionized calcium levels, arterial blood-gas tensi...
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journal_title：Journal of critical care
pub_type： 杂志文章
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更新日期：1994-03-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2018-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2016.05.016
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journal_title：Journal of critical care
pub_type： 杂志文章,评审
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journal_title：Journal of critical care
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更新日期：2015-02-01 00:00:00
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更新日期：2003-03-01 00:00:00
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journal_title：Journal of critical care
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of critical care
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abstract：:Within a prospective, observational, multi-center cohort study 68 hospitals (of which 66 responded), mostly academic (n = 60, 91%) level I trauma centers (n = 44, 67%) in 20 countries were asked to complete questionnaires regarding the "standard of care" for severe neurotrauma patients in their hospitals. From the que...
journal_title：Journal of critical care
pub_type： 杂志文章,多中心研究
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更新日期：2019-02-01 00:00:00
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