Abstract：
PURPOSE:Alcohol-use disorders (AUDs) have been associated with increased sepsis-related mortality. As patients with AUDs are often thiamine deficient, we investigated practice patterns relating to thiamine administration in patients with AUDs presenting with septic shock and explored the association between receipt of thiamine and mortality. MATERIALS:We performed a retrospective cohort study of patients presenting with septic shock between 2008 and 2014 at a single tertiary care center. We identified patients with an AUD diagnosis, orders for microbial cultures and use of antibiotics, vasopressor dependency, and lactate levels≥4mmol/L. We excluded those who received thiamine later than 48h of sepsis onset. RESULTS:We included 53 patients. Thirty-four (64%) patients received thiamine. Five patients (15%) received their first thiamine dose in the emergency department. The median time to thiamine administration was 9 (quartiles: 4, 18) hours. The first thiamine dose was most often given parenterally (68%) and for 100mg (88%). In those receiving thiamine, 15/34 (44%) died, compared to 15/19 (79%) of those not receiving thiamine, p=0.02. CONCLUSIONS:A considerable proportion of patients with AUDs admitted for septic shock do not receive thiamine. Thiamine administration in this patient population was associated with decreased mortality.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Holmberg MJ,Moskowitz A,Patel PV,Grossestreuer AV,Uber A,Stankovic N,Andersen LW,Donnino MWdoi
10.1016/j.jcrc.2017.08.022subject
Has Abstractpub_date
2018-02-01 00:00:00pages
61-64eissn
0883-9441issn
1557-8615pii
S0883-9441(17)30706-2journal_volume
43pub_type
杂志文章abstract：INTRODUCTION:The HACOR scale is a clinical score that can predict early failure of NIV in hypoxemic acute respiratory failure (ARF) The aim of this study is to analyze the validity of the HACOR scale. METHODS:A retrospective study of a cohort of over 2749 episodes on 2711 consecutive patients requiring NIV for hypoxem...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2020.08.008
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:The purpose of the study is to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation (MV) in pneumonia patients with hypoxemic acute respiratory failure (ARF) treated with high-flow nasal cannula (HFNC). MATERIALS AND METHODS:This is a 4-year ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2016.05.022
更新日期：2016-10-01 00:00:00
abstract：:Advances in the management of malignancies and organ failures have led to substantial increases in survival as well as in the number of cancer patients requiring intensive care unit (ICU) admission. Although effectiveness of ICU in this group remains controversial, the heterogeneity of its population in terms of the n...
journal_title：Journal of critical care
pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2014.04.007
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:Thyrotoxicosis-induced cardiomyopathy (TCM) is a rare, potentially life-threatening complication requiring extracorporeal membrane oxygenation (ECMO) for temporary mechanical support while a euthyroid state is being achieved. MATERIALS AND METHODS:The current review searched Ovid Medline and PubMed for all rel...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2018.01.026
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:To investigate the relationship between immature granulocyte percentage (IG%) and acute respiratory distress syndrome (ARDS) in patients with acute pancreatitis (AP). MATERIALS AND METHODS:A cohort of 2289 patients with AP was screened; 1933 were enrolled in this prospective multicenter study. Blood samples fo...
journal_title：Journal of critical care
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrc.2018.12.002
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:We present a new electromyographic index, named Engagement of Respiratory Muscle (ERM), for assessing the level of participation of respiratory muscles during spontaneous breathing test in patients poisoned with organophosphorus compound. METHODS:Diaphragm and sternocleidomastoid muscles activity was recorded ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2017.05.022
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:The purpose of this retrospective study was to evaluate cardiac troponin-I (cTnI) as a 28-day mortality prognosticator and predictor for a drotrecogin alfa (activated) (DrotAA) survival benefit in recombinant human activated Protein C Worldwide Evaluation in Severe Sepsis patients. METHODS:Cardiac troponin-I w...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2009.12.001
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Changes in mean perfusion pressure (MPP) from premorbid resting values may contribute to the progression of septic acute kidney injury (AKI). OBJECTIVES:In patients with septic shock, we aimed to investigate the association of changes from premorbid values with AKI severity and progression. METHODS:We obta...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2015.05.003
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:Frailty in critical illness is common and associated with poor outcomes, however little is known about contributing factors. We compared the Clinical Frailty Scale (CFS) with a multi-dimensional validated tool, the Edmonton Frail Scale (EFS), and investigated which health domains are affected by frailty in ICU....
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2019.04.032
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:Automated weaning modes are available in some mechanical ventilators, but no studies compared them hitherto. We compared the performance of 3 automated modes under standard and challenging situations. METHODS:We used a lung simulator to compare 3 automated modes, adaptive support ventilation (ASV), mandatory r...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2011.12.021
更新日期：2012-12-01 00:00:00
abstract：:Hypernatremia is common in intensive care units. It has detrimental effects on various physiologic functions and was shown to be an independent risk factor for increased mortality in critically ill patients. Mechanisms of hypernatremia include sodium gain and/or loss of free water and can be discriminated by clinical ...
journal_title：Journal of critical care
pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2012.05.001
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:This study measured the quality of data extracted from a clinical information system widely used for critical care quality improvement and research. MATERIALS AND METHODS:We abstracted data from 30 fields in a random sample of 207 patients admitted to nine adult, medical-surgical intensive care units. We asses...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2018.07.021
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Ventilator-associated pneumonia (VAP) is an important cause of morbidity and mortality in ventilated critically ill patients. PURPOSE:To develop evidence-based guidelines for the prevention of VAP. DATA SOURCES:MEDLINE, EMBASE, CINAHL, and the Cochrane Database of Systematic Reviews and Register of Control...
journal_title：Journal of critical care
pub_type： 杂志文章,实务指引
doi：10.1016/j.jcrc.2007.11.014
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:The prevalence and clinical significance of lactic acidosis in diabetic ketoacidosis (DKA) are understudied. The objective of this study was to determine the prevalence of lactic acidosis in DKA and its association with intensive care unit (ICU) length of stay (LOS) and mortality. METHODS:Retrospective, observ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2011.07.071
更新日期：2012-04-01 00:00:00
abstract：INTRODUCTION:Given the complexity of biological systems, understanding their dynamic behaviors, such as the Acute Inflammatory Response (AIR), requires a formal synthetic process. Dynamic Mathematical Modeling (DMM) represents a suite of methods intended for inclusion within the required synthetic framework. The DMM, h...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2006.12.001
更新日期：2007-03-01 00:00:00
abstract：PURPOSE:The aim of this study was to validate and compare the performance of the Acute Physiology and Chronic Health Evaluation (APACHE) IV in the Dutch intensive care unit (ICU) population to the APACHE II and Simplified Acute Physiology Score (SAPS) II. MATERIALS AND METHODS:This is a prospective study based on data...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2010.07.007
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:A nationwide increase in the rate and severity of Clostridium difficile-associated disease may reflect infection with a virulent strain characterized by polymerase chain reaction as ribotype 027 (NAP1/B1). HYPOTHESIS:The high prevalence of ribotype 027 at our institution would allow investigation of the ris...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2009.04.002
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:Although 4% albumin is associated with increased mortality in patients with traumatic brain injury (TBI), evidence concerning the safety of synthetic colloids is lacking. We aimed to determine if there is an association between synthetic colloids and mortality in patients with severe TBI. MATERIALS AND METHODS...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2010.12.001
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:The objective of this study is to evaluate the benefits of adjuvant treatment with crude rhubarb in patients with systemic inflammation reaction syndrome/sepsis by conducting a meta-analysis. METHODS:We conducted a systematic literature search of medical electronic databases (up to October 2013). Only random...
journal_title：Journal of critical care
pub_type： 杂志文章,meta分析
doi：10.1016/j.jcrc.2014.11.008
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:The specific norepinephrine dose at which epinephrine should be added in septic shock is unclear. This study sought to determine the norepinephrine-equivalent dose at epinephrine initiation that correlated with hemodynamic stability. METHODS:Septic shock patients receiving both norepinephrine and epinephrine w...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2019.05.024
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:The criteria for starting extracorporeal membrane oxygenation (ECMO) therapy in term newborn patients with hypoxemic respiratory failure consist of an oxygenation index (OI) of 25 or higher and alveolar-arterial oxygen (Aao(2)) gradient of more than 600 at sea level. In such conditions, inhaled nitric oxide (iN...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2005.05.011
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Resident physicians' beliefs about cardiopulmonary resuscitation (CPR) may impact their communication with patients about end-of-life care. We sought to understand how these perceptions and experiences have changed in the past decade because both medical education and American society have focused more on th...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2007.12.012
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:The goal of this study was to determine the impact of surgical rib fixation (SRF) in a treatment protocol for severe blunt chest trauma. MATERIALS AND METHODS:Patients with flail chest admitted between September 2009 and June 2010 to our level I trauma center who failed traditional management and underwent SRF...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2013.08.003
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:To narratively review published information on prevention, detection, pathophysiology, and appropriate treatment of vascular air embolism (VAE). MATERIALS AND METHODS:MEDLINE, SCOPUS, Cochrane Central Register and Google Scholar databases were searched for data published through October 2016. The Manufacturer ...
journal_title：Journal of critical care
pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2017.08.010
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:Pneumothorax is present as a frequent complication in acute respiratory distress syndrome (ARDS). Persistent air leak (PAL) prolongs pneumothorax in 2% of cases of ARDS, increasing the rate of mortality by 26%. Pleurodesis using autologous blood (PAB) is an effective method in cases of oncological pulmonary s...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2005.10.003
更新日期：2006-06-01 00:00:00
abstract：PURPOSE:The ratio of right ventricular end-diastolic diameter (EDD) to left ventricular EDD (RV/LV) is a measure predictive of right ventricular failure. We hypothesized that an increase in RV/LV would be associated with poor prognosis in severe sepsis and septic shock. MATERIALS AND METHODS:This is a retrospective ch...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2018.09.025
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:The purpose of the study is to reduce unnecessary ordering of routine-priority blood tests. METHODS:In this before-after study, we studied all patients admitted to a 15-bed tertiary intensive care unit (ICU) from July 1, 2011, to June 27, 2013. Based on input from intensivists, acceptable indications for order...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2015.09.013
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:There is wide variation in the practice of acute renal replacement therapy (RRT). Quality of care is suboptimal, and substantial knowledge-to-care gaps need to be addressed. The quality of care for patients receiving acute RRT has been recognized as a clinical and research priority. Quality indicators (QIs) can...
journal_title：Journal of critical care
pub_type： 共识发展会议,杂志文章
doi：10.1016/j.jcrc.2019.07.003
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:The purpose was to determine prognosis of patients presenting extreme acidosis (pH <7) on admission to the intensive care unit (ICU) and to identify mortality risk factors. MATERIALS AND METHODS:We retrospectively analyzed all patients who presented with extreme acidosis within 24 hours of admission to a polyv...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2015.09.025
更新日期：2016-02-01 00:00:00
abstract：:Recent advances in the field of molecular biology have revolutionized our understanding of the functioning of living organisms and facilitated the development of robust tools for both diagnosis and treatment of diseases. With particular reference to the field of critical care medicine, development of molecular biology...
journal_title：Journal of critical care
pub_type： 杂志文章,评审
doi：10.1016/0883-9441(95)90004-7
更新日期：1995-09-01 00:00:00
