Abstract：
PURPOSE:The purpose of this retrospective study was to evaluate cardiac troponin-I (cTnI) as a 28-day mortality prognosticator and predictor for a drotrecogin alfa (activated) (DrotAA) survival benefit in recombinant human activated Protein C Worldwide Evaluation in Severe Sepsis patients. METHODS:Cardiac troponin-I was measured using the Access AccuTnI Troponin I assay (Beckman Coulter, Fullerton, CA). There were 598 patients (305 DrotAA, 293 placebo) with baseline cTnI data (cTnI negative [<0.06 ng/mL], n = 147; cTnI positive [>or=0.06 ng/mL], n = 451). RESULTS:Cardiac troponin-I-positive patients were older (mean age, 61 vs 56 years; P = .002), were sicker (mean Acute Physiology and Chronic Health Evaluation II, 26.1 vs 22.3; P < .001), had lower baseline protein C levels (mean level, 49% vs 56%; P = .017), and had higher 28-day mortality (32% vs 14%, P < .0001) than cTnI-negative patients. Elevated cTnI was an independent prognosticator of mortality (odds ratio, 2.020; 95% confidence interval, 1.153-3.541) after adjusting for other significant variables. Breslow-Day interaction test between cTnI levels and treatment was not significant (P = .65). CONCLUSION:This is the largest severe sepsis study reporting an association between elevated cTnI and higher mortality. Cardiac troponin-I elevation was not predictive of a survival benefit with DrotAA treatment.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
John J,Woodward DB,Wang Y,Yan SB,Fisher D,Kinasewitz GT,Heiselman Ddoi
10.1016/j.jcrc.2009.12.001subject
Has Abstractpub_date
2010-06-01 00:00:00pages
270-5issue
2eissn
0883-9441issn
1557-8615pii
S0883-9441(09)00287-1journal_volume
25pub_type
杂志文章abstract：PURPOSE:The purpose of this article was to determine the outcome, clinical and prognostic features, and microbiology of a large group of patients with community-acquired pneumonia (CAP) presenting in septic shock. MATERIALS AND METHODS:The placebo limb of the Norasept II database was examined. Data were collected on p...
journal_title：Journal of critical care
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更新日期：2000-09-01 00:00:00
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journal_title：Journal of critical care
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journal_title：Journal of critical care
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journal_title：Journal of critical care
pub_type： 杂志文章,随机对照试验
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更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION:Patients with septic shock often receive intravenous vasopressor infusions, with little evidence available to guide their titration. We surveyed Canadian intensivists to document self-reported vasopressor titration strategies for patients with septic shock. METHODS:We identified Canadian intensivists cari...
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journal_title：Journal of critical care
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更新日期：2005-06-01 00:00:00
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journal_title：Journal of critical care
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更新日期：2014-06-01 00:00:00
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更新日期：2018-12-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrc.2018.11.002
更新日期：2019-02-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/s0883-9441(97)90026-5
更新日期：1997-12-01 00:00:00
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doi：10.1016/j.jcrc.2014.12.008
更新日期：2015-06-01 00:00:00
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journal_title：Journal of critical care
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doi：10.1016/j.jcrc.2017.10.009
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journal_title：Journal of critical care
pub_type： 杂志文章,随机对照试验
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更新日期：2016-04-01 00:00:00
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journal_title：Journal of critical care
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doi：10.1016/j.jcrc.2014.06.003
更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2016.05.016
更新日期：2016-10-01 00:00:00
abstract：:There is a need for neuromuscular relaxant (NMR) agents that are of the "nondepolarizing type" and produce rapidly developing and short-lasting skeletal muscle relaxation in anesthesiology. Many efforts have been directed to produce such agents. Our research focused on the design, synthesis, and evaluation of numerous...
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pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2008.08.005
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:This paper describes the methodology of a clinical trial of prone positioning in pediatric patients with acute lung injury (ALI). Nonrandomized studies suggest that prone positioning improves oxygenation in patients with ALI/acute respiratory distress syndrome without the risk of serious iatrogenic injury. It i...
journal_title：Journal of critical care
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jcrc.2005.12.004
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:The purpose of the study was to investigate the pharmacokinetics of combined intravenous (i.v.) and intracerebroventricular (i.c.v.) vancomycin for patients with intracranial infections after craniotomy and to provide the basis for establishing the intracranial local administration criterion. METHODS:Fourtee...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2014.09.020
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:Previous studies have shown that heart rate complexity may be a useful indicator of patient status in the critical care environment but will require continuous, accurate, and automated R-wave detection (RWD) in the electrocardiogram (ECG). Although numerous RWD algorithms exist, accurate detection remains a cha...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2013.02.015
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:To compare the rate of therapeutic failure in critically ill patients treated by third-generation cephalosporins (3GCs) or piperacillin-tazobactam (PTZ) for wild-type AmpC-producing Enterobacterales pulmonary infections. METHODS:Over a 4-year period, all adult patients treated for a wild-type AmpC-producing En...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2019.11.005
更新日期：2020-04-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
