Abstract:
:Hemoglobin-based oxygen carriers (HBOCs) are used in extreme circumstances to increase hemoglobin concentration and improve oxygen delivery when allogenic red blood cell transfusions are contraindicated or not immediately available. However, HBOC-induced severe pulmonary and systemic vasoconstriction due to peripheral nitric oxide (NO) scavenging has stalled its implementation in clinical practice. We present a case of an 87 year-old patient with acute life-threatening anemia who received HBOC while breathing NO gas. This case shows that inhaled NO allows for the safe use of HBOC infusion by preventing HBOC-induced pulmonary and systemic vasoconstriction.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Marrazzo F,Larson G,Sherpa Lama TT,Teggia Droghi M,Joyce M,Ichinose F,Watkins MT,Stowell C,Crowley J,Berra Ldoi
10.1016/j.jcrc.2018.04.008subject
Has Abstractpub_date
2019-06-01 00:00:00pages
213-216eissn
0883-9441issn
1557-8615pii
S0883-9441(18)30201-6journal_volume
51pub_type
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