Inhaled nitric oxide prevents systemic and pulmonary vasoconstriction due to hemoglobin-based oxygen carrier infusion: A case report.

Abstract:

:Hemoglobin-based oxygen carriers (HBOCs) are used in extreme circumstances to increase hemoglobin concentration and improve oxygen delivery when allogenic red blood cell transfusions are contraindicated or not immediately available. However, HBOC-induced severe pulmonary and systemic vasoconstriction due to peripheral nitric oxide (NO) scavenging has stalled its implementation in clinical practice. We present a case of an 87 year-old patient with acute life-threatening anemia who received HBOC while breathing NO gas. This case shows that inhaled NO allows for the safe use of HBOC infusion by preventing HBOC-induced pulmonary and systemic vasoconstriction.

journal_name

J Crit Care

journal_title

Journal of critical care

authors

Marrazzo F,Larson G,Sherpa Lama TT,Teggia Droghi M,Joyce M,Ichinose F,Watkins MT,Stowell C,Crowley J,Berra L

doi

10.1016/j.jcrc.2018.04.008

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

213-216

eissn

0883-9441

issn

1557-8615

pii

S0883-9441(18)30201-6

journal_volume

51

pub_type

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