Abstract：
PURPOSE:Gastric intramucosal PCO2 (PiCO2) is a marker of splanchnic dysoxia and hypoperfusion that is increasingly used in intensive care medicine. We assessed two methods, saline-balloon tonometry versus continuous capnometric recirculating gas tonometry (CRGT), for detecting changes in PiCO2 in animals subjected to various degrees of hemorrhage and examined whether changes in PiCO2 would correlate with the degree of hemorrhage as assessed by blood loss volume. MATERIALS AND METHODS:Following a baseline equilibration period, 20 anesthetized dogs were subjected to bleeding of 0, 23, 35, 41, or 47 mL/kg. After 30 minutes, the shed blood was reinfused and the experiments continued for an additional 120 minutes. RESULTS:Aggregate baseline PiCO2 was 43 mm Hg by both methods. PiCO2 did not change significantly over time in the control animals by either method. PiCO2 by CRGT rose significantly in each of the other groups at the end of the hemorrhage period and after resuscitation. Similar trends were observed in PiCO2 measured by saline tonometry but were significant only with the most severe hemorrhage. Strong correlation was observed between the degree of hemorrhage and change in PiCO2 by both methods. CONCLUSION:PiCO2 serves as a quantitative indicator of the severity of hypovolemic perfusion failure associated with hemorrhage. Compared with standard saline tonometry, CRGT may be a more sensitive method of monitoring the severity of hemorrhage.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Guzman JA,Kruse JAdoi
10.1016/s0883-9441(98)80001-4subject
Has Abstractpub_date
1998-06-01 00:00:00pages
49-54issue
2eissn
0883-9441issn
1557-8615pii
S0883-9441(98)80001-4journal_volume
13pub_type
杂志文章abstract：PURPOSE:Bacterial ventriculitis (BV) may develop in patients requiring external ventricular drains (EVDs). The purpose of this study was to determine predictors of EVD-associated BV onset. MATERIALS AND METHODS:A retrospective review of Duke University Hospital patients with EVD device placement between January 2005 a...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2013.08.012
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:Thoracocardiography noninvasively monitors global stroke volume by inductive plethysmographic recording of ventricular volume curves as previously validated by thermodilution. Our purpose was to investigate the potential of thoracocardiography to individually assess stroke volume of the left ventricle. We hypot...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/s0883-9441(98)90019-3
更新日期：1998-09-01 00:00:00
abstract：PURPOSE:The study aimed to compare hemoglobin (Hb) values determined using the portable HemoCue system (HemoCue Hb 201+; HemoCue AB, Ängelholm, Sweden) with laboratory Hb level determination. MATERIALS AND METHODS:Adult patients hospitalized in our surgical intensive care unit who required an Hb level determination we...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2010.08.012
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:Current guidelines for traumatic brain injury (TBI) recommend antiepileptic drugs (AEDs) for 7 days after injury to decrease posttraumatic seizure risk. Phenytoin decreases seizure risk 73% vs placebo during this time. Levetiracetam (LEV) is an alternative; however, no published data validate comparable efficac...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2012.11.020
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:To explore perspectives of adult critical illness survivors and identify important aspects to care and recovery. MATERIALS AND METHODS:A descriptive, qualitative study of adult survivors of prolonged critical illness, six-months after Intensive Care Unit (ICU) discharge, using semi-structured interviews and th...
journal_title：Journal of critical care
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Newly updated guidelines suggest brain computed tomography for out-of-hospital cardiac arrest survivors to identify a neurologic cardiac arrest cause. We hypothesized that the "pseudo-subarachnoid hemorrhage" (p-SAH) sign in cardiac arrest survivors is associated with poor outcome. MATERIALS AND METHODS:We ret...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2017.02.021
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:The purpose was to investigate the association between acid-base disturbances and mortality in acute poisoning. MATERIALS AND METHODS:We performed a retrospective cross-sectional exploratory study on all acutely poisoned patients older than 12 years who had been admitted to the main tertiary toxicology hospita...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2016.05.003
更新日期：2016-10-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2018.09.035
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:To investigate the effect of increasing spinal cord perfusion pressure (SCPP) on sensory evoked potentials (SEPs) and injury site metabolism in patients with severe traumatic spinal cord injury TSCI. MATERIALS AND METHODS:In 12 TSCI patients we placed a pressure probe, a microdialysis catheter and a strip elec...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2019.12.019
更新日期：2020-04-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2005.06.005
更新日期：2005-09-01 00:00:00
abstract：PURPOSE:Oxygen (O2) is the most common therapy in mechanically ventilated patients, but targets and dose are poorly understood. We aimed to describe current O2 administration and titration in such patients in an academic intensive care unit. MATERIALS AND METHODS:In consecutive ventilated (>48 hours) patients we prosp...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2013.03.010
更新日期：2013-10-01 00:00:00
abstract：:Cell-free circulating DNA (cf-DNA) can be detected by various of laboratory techniques. We described a branched DNA-based Alu assay for measuring cf-DNA in septic patients. Compared to healthy controls and systemic inflammatory response syndrome (SIRS) patients, serum cf-DNA levels were significantly higher in septic ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2015.10.013
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:We aimed to determine whether diarrhea experienced by patients in the intensive care unit (ICU) is related to their clinical outcomes. MATERIAL AND METHODS:We performed a systematic review and meta-analysis. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, and the World ...
journal_title：Journal of critical care
pub_type： 杂志文章,meta分析
doi：10.1016/j.jcrc.2019.06.014
更新日期：2019-10-01 00:00:00
abstract：:Sepsis and SIRS is the outward manifestation of a generalized uncontrolled inflammatory response, which, if sustained, induces widespread endothelial damage and MODS. Immunomodulating therapies, at present, have proven ineffective in reducing morbidity and mortality, presumably because of the heterogeneous nature of s...
journal_title：Journal of critical care
pub_type： 杂志文章,评审
doi：10.1016/s0883-9441(96)90024-6
更新日期：1996-06-01 00:00:00
abstract：PURPOSE:To assess the risk factors for invasive Candida infection (ICI) caused by fluconazole-resistant (Flu-R) Candida species in intensive care unit (ICU) patients. MATERIALS AND METHODS:Data from China Survey of Candidiasis study were analyzed. Patients with proven ICI were classified into fluconazole-sensitive (Fl...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2015.04.002
更新日期：2015-08-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2015.09.016
更新日期：2016-02-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrc.2017.08.032
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:Multiple equations exist for predicting resting energy expenditure (REE). The accuracy of these for estimating energy requirements of critically ill patients is not clear, especially for obese patients. We sought to compare REE, calculated with published formulas, with measured REE in a cohort of mechanically v...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2011.07.084
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:The present study tested the hypothesis that scorpion sting induces left ventricular (LV) hypokinesia and myocardial ischemia shortly after injection due to reduction of coronary blood flow (CBF) and increased oxygen demand. METHODS:In 5 mechanically ventilated, open-chest dogs, we measured LV function followi...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/0883-9441(94)90024-8
更新日期：1994-06-01 00:00:00
abstract：:Advances in the management of malignancies and organ failures have led to substantial increases in survival as well as in the number of cancer patients requiring intensive care unit (ICU) admission. Although effectiveness of ICU in this group remains controversial, the heterogeneity of its population in terms of the n...
journal_title：Journal of critical care
pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2014.04.007
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:Mortality in severe sepsis and septic shock (SS/SS) remains high. Surviving Sepsis Campaign (SSC) guidelines were published in 2004 with the goal of improving outcomes in SS/SS. We tested the hypothesis that adherence to SSC guidelines and management of patients with SS/SS were influenced by physician specialty...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2010.04.005
更新日期：2010-12-01 00:00:00
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journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2005.09.057
更新日期：2006-03-01 00:00:00
abstract：:Invasive pulmonary aspergillosis (IPA) is an emerging and life-threatening infectious disease in patients admitted to the intensive care unit (ICU). Most diagnostic studies are conducted in hematological patients and results cannot readily be transferred to ICU patients lacking classical host factors. In a multicenter...
journal_title：Journal of critical care
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrc.2018.07.001
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Increasingly, hospitals are engaging in continuous quality improvement (CQI) endeavors, aimed at optimizing patient care. Physician involvement is critical to the success of such initiatives. Little is known about any mediating factors that affect physician participation in these projects, though such knowledge...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1053/jcrc.2001.30165
更新日期：2001-12-01 00:00:00
abstract：PURPOSE:Early posttracheostomy tracheal stenosis (PTTS) may cause weaning and decannulation failure. Although bronchoscopic recanalization offers an effective treatment, it is not known how successfully patients can be weaned and decannulated after recanalization. The aims of this study were to determine the incidence ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2014.03.023
更新日期：2014-08-01 00:00:00
abstract：INTRODUCTION:Given the complexity of biological systems, understanding their dynamic behaviors, such as the Acute Inflammatory Response (AIR), requires a formal synthetic process. Dynamic Mathematical Modeling (DMM) represents a suite of methods intended for inclusion within the required synthetic framework. The DMM, h...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2006.12.001
更新日期：2007-03-01 00:00:00
abstract：PURPOSE:Analgesia and sedation protocols (ASPs) reduce duration of mechanical ventilation (MV) in the medical intensive care unit (ICU), but data in the surgical ICU (SICU) are limited. The objective of this study was to determine the impact of a nursing-driven ASP with criteria for infusion initiation in the SICU. MA...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2018.11.029
更新日期：2019-04-01 00:00:00
abstract：:Hypernatremia is common in intensive care units. It has detrimental effects on various physiologic functions and was shown to be an independent risk factor for increased mortality in critically ill patients. Mechanisms of hypernatremia include sodium gain and/or loss of free water and can be discriminated by clinical ...
journal_title：Journal of critical care
pub_type： 杂志文章,评审
doi：10.1016/j.jcrc.2012.05.001
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:Sepsis damages the endothelial glycocalyx, contributing to fluid extravasation, organ injury, and death. Our goal was to determine if syndecan-1 level is associated with the risk of intubation and modifying effect of intravenous fluids (IVFs) in these patients. METHODS:Syndecan-1 was measured at enrollment in ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2016.06.027
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:The purpose of the study is to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation (MV) in pneumonia patients with hypoxemic acute respiratory failure (ARF) treated with high-flow nasal cannula (HFNC). MATERIALS AND METHODS:This is a 4-year ...
journal_title：Journal of critical care
pub_type： 杂志文章
doi：10.1016/j.jcrc.2016.05.022
更新日期：2016-10-01 00:00:00
