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Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series.

Abstract：

:Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular risk factors in promoting oxidative stress: diabetes, obesity, smoking, and excessive pollution. Specifically, the risk of developing heart failure is higher in patients with diabetes or obesity, even with optimal medical treatment, and the increased release of ROS from cardiac mitochondria and other sources likely contributes to the development of cardiac dysfunction in this setting. Here, we explore the role of different ROS sources arising in obesity and diabetes, and the effect of excessive ROS production on the development of cardiac lipotoxicity. In parallel, contaminants in the air that we breathe pose a significant threat to human health. This paper provides an overview of cigarette smoke and urban air pollution, considering how their composition and biological effects have detrimental effects on cardiovascular health.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Niemann B,Rohrbach S,Miller MR,Newby DE,Fuster V,Kovacic JC

doi

10.1016/j.jacc.2017.05.043

subject

Has Abstract

pub_date

2017-07-11 00:00:00

pages

230-251

issue

2

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(17)37510-1

journal_volume

70

pub_type

杂志文章,评审

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