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Exercise Intolerance in Patients With Heart Failure: JACC State-of-the-Art Review.

Abstract：

:Exercise intolerance is the cardinal symptom of heart failure (HF) and is of crucial relevance, because it is associated with a poor quality of life and increased mortality. While impaired cardiac reserve is considered to be central in HF, reduced exercise and functional capacity are the result of key patient characteristics and multisystem dysfunction, including aging, impaired pulmonary reserve, as well as peripheral and respiratory skeletal muscle dysfunction. We herein review the different modalities to quantify exercise intolerance, the pathophysiology of HF, and comorbid conditions as they lead to reductions in exercise and functional capacity, highlighting the fact that distinct causes may coexist and variably contribute to exercise intolerance in patients with HF.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Del Buono MG,Arena R,Borlaug BA,Carbone S,Canada JM,Kirkman DL,Garten R,Rodriguez-Miguelez P,Guazzi M,Lavie CJ,Abbate A

doi

10.1016/j.jacc.2019.01.072

subject

Has Abstract

pub_date

2019-05-07 00:00:00

pages

2209-2225

issue

17

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(19)33923-3

journal_volume

73

pub_type

杂志文章,评审

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