当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Baroreflex sensitivity and variants of the renin angiotensin system genes.

Baroreflex sensitivity and variants of the renin angiotensin system genes.

Abstract：

OBJECTIVES:Because the renin-angiotensin-aldosterone system (RAS) modifies cardiovascular autonomic regulation, we studied the possible associations between baroreflex sensitivity (BRS) and polymorphism in the RAS genes. BACKGROUND:Wide intersubject variability in BRS is not well explained by cardiovascular risk factors or life style, suggesting a genetic component responsible for the variation of BRS. METHODS:Baroreflex sensitivity as measured from the overshoot phase of the Valsalva maneuver and genetic polymorphisms were examined in a random sample of 161 women and 154 men aged 41 to 61 years and then in an independent random cohort of 29 men and 37 women aged 36 to 37 years. An insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE), M235T variants of angiotensinogen (AGT) and two diallelic polymorphisms in the gene encoding aldosterone synthase (CYP11B2), one in the promoter (-344C/T) and the other in the second intron, were identified by polymerase chain reaction. RESULTS:In the older population, BRS differed significantly across CYP11B2 genotype groups in women (10.1 +/- 4.5, 8.7 +/- 3.8 and 7.1 +/- 3.2 ms x mm Hg(-1) in genotypes -344TT, CT and CC, respectively, p = 0.003 and 11.1 +/- 4.4, 8.9 +/- 4.1 and 7.5 +/- 3.4 ms x mm Hg(-1) in intron 2 genotypes 1/1, 1/2 and 2/2, respectively, p = 0.002), but not in men. No comparable associations were found for BRS with the I/D polymorphism of ACE or the M235T variant of AGT. In the younger population, BRS was even more strongly related to the CYP11B2 promoter genotype (p = 0.0003). The association was statistically significant both in men (p = 0.015) and in women (p = 0.03). CONCLUSIONS:Common genetic polymorphisms in the aldosterone synthase (CYP11B2) gene is associated with interindividual variation in BRS.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Ylitalo A,Airaksinen KE,Hautanen A,Kupari M,Carson M,Virolainen J,Savolainen M,Kauma H,Kesäniemi YA,White PC,Huikuri HV

doi

10.1016/s0735-1097(99)00506-9

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

194-200

issue

1

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(99)00506-9

journal_volume

35

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Primary results of the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT). A multicenter study of B-type natriuretic peptide levels, emergency department decision making, and outcomes in patients presenting with shortness of breath.

    abstract：OBJECTIVES:The purpose of this study was to examine the relationships among B-type natriuretic peptide (BNP) levels within the diagnostic range, perceived congestive heart failure (CHF) severity, clinical decision making, and outcomes of the CHF patients presenting to emergency department (ED). BACKGROUND:Since BNP co...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.jacc.2004.06.015

    authors： Maisel A,Hollander JE,Guss D,McCullough P,Nowak R,Green G,Saltzberg M,Ellison SR,Bhalla MA,Bhalla V,Clopton P,Jesse R,Rapid Emergency Department Heart Failure Outpatient Trial investigators.

    更新日期：2004-09-15 00:00:00

  • Diagnostic utility of mechanical, pharmacological and orthostatic stimulation of the carotid sinus in patients with unexplained syncope.

    abstract：OBJECTIVES:The purpose of the present study was to systematically evaluate the diagnostic utility of mechanical, pharmacological and orthostatic stimulation of the carotid sinus in a consecutive series of patients with recurrent unexplained syncope. BACKGROUND:Carotid sinus hypersensitivity (CSH) is an infrequently re...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00365-4

    authors： Morillo CA,Camacho ME,Wood MA,Gilligan DM,Ellenbogen KA

    更新日期：1999-11-01 00:00:00

  • Age as a risk factor for stroke in atrial fibrillation patients: implications for thromboprophylaxis.

    abstract：:The prevalence of atrial fibrillation (AF) is related to age and is projected to rise exponentially as the population ages and the prevalence of cardiovascular risk factors increases. The risk of ischemic stroke is significantly increased in AF patients, and there is evidence of a graded increased risk of stroke assoc...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2010.05.028

    authors： Marinigh R,Lip GY,Fiotti N,Giansante C,Lane DA

    更新日期：2010-09-07 00:00:00

  • Sudden death in a pediatric cardiology population, 1958 to 1983: relation to prior arrhythmias.

    abstract：:This review of sudden death in patients previously seen in a pediatric cardiology clinic attempts to identify factors that may have been predictive of sudden death. The denominator for these factors is unknown. For example, the number of patients with these possible risk factors who have well tolerated arrhythmias is ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80543-x

    authors： Garson A Jr,McNamara DG

    更新日期：1985-06-01 00:00:00

  • Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction.

    abstract：OBJECTIVES:We sought to evaluate the prognostic impact of right ventricular (RV) myocardial involvement in patients with inferior myocardial infarction (MI). BACKGROUND:There is uncertainty regarding the risk of major complications in patients with inferior MI complicated by RV myocardial involvement. Whether these co...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,meta分析,多中心研究,随机对照试验

    doi：10.1016/s0735-1097(00)01089-5

    authors： Mehta SR,Eikelboom JW,Natarajan MK,Diaz R,Yi C,Gibbons RJ,Yusuf S

    更新日期：2001-01-01 00:00:00

  • Predictors of late development of heart failure in stable survivors of myocardial infarction: the CARE study.

    abstract：OBJECTIVES:We sought to determine the predictors of heart failure (HF) development in long-term survivors of myocardial infarction (MI). BACKGROUND:Modern strategies of acute MI care have resulted in an increasing proportion of survivors at heightened risk of future non-fatal events, including HF. METHODS:We assessed...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(03)01057-x

    authors： Lewis EF,Moye LA,Rouleau JL,Sacks FM,Arnold JM,Warnica JW,Flaker GC,Braunwald E,Pfeffer MA,CARE Study.

    更新日期：2003-10-15 00:00:00

  • Myocardial infarction patients in the 1990s--their risk factors, stratification and survival in Canada: the Canadian Assessment of Myocardial Infarction (CAMI) Study.

    abstract：OBJECTIVES:This study sought to evaluate the in-hospital and postdischarge mortality of patients with an acute myocardial infarction in the 1990s. BACKGROUND:The widespread implementation of therapeutic interventions that modify the natural history of coronary artery disease has led to changes in the profile and survi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00599-4

    authors： Rouleau JL,Talajic M,Sussex B,Potvin L,Warnica W,Davies RF,Gardner M,Stewart D,Plante S,Dupuis R,Lauzon C,Ferguson J,Mikes E,Balnozan V,Savard P

    更新日期：1996-04-01 00:00:00

  • Russek Lecture. Must cardiology lose its heart?

    abstract：:Regulations and restrictions imposed by external agencies are forcing cardiologists into an unnatural self-protective and defensive posture against their patients. The key to breaking the pattern of mutual skepticism and mistrust lies in returning the focus to its rightful place: the patients' needs. Thus, payment sys...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(92)90630-6

    authors： Gorlin R

    更新日期：1992-06-01 00:00:00

  • Investigation of the mechanism of chest pain in patients with angiographically normal coronary arteries using transesophageal dobutamine stress echocardiography.

    abstract：OBJECTIVES:The present study sought to determine whether myocardial contractile abnormalities accompany the development of chest pain in patients with normal coronary angiograms. BACKGROUND:The mechanism of chest pain in patients with angina despite a normal coronary arteriogram is controversial. Although previous stu...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(96)00481-0

    authors： Panza JA,Laurienzo JM,Curiel RV,Unger EF,Quyyumi AA,Dilsizian V,Cannon RO 3rd

    更新日期：1997-02-01 00:00:00

  • Inappropriate sinus tachycardia.

    abstract：:Inappropriate sinus tachycardia (IST) is a syndrome in which the sinus heart rate is inexplicably faster than expected and associated symptoms are present. The heart rate at rest, even in a supine position, can exceed 100 beats/min; minimal activity accelerates the rate rapidly and substantially. Patients with IST may...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2012.07.074

    authors： Olshansky B,Sullivan RM

    更新日期：2013-02-26 00:00:00

  • Long-term subthreshold electrical stimulation of the left stellate ganglion and a canine model of sudden cardiac death.

    abstract：OBJECTIVES:We sought to develop a high-yield canine model of sudden cardiac death (SCD). BACKGROUND:Because electrical stimulation is a powerful means to elicit nerve sprouting, we hypothesize that subthreshold electrical stimulation is more effective than nerve growth factor (NGF) infusion in inducing nerve sprouting...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2003.07.053

    authors： Swissa M,Zhou S,Gonzalez-Gomez I,Chang CM,Lai AC,Cates AW,Fishbein MC,Karagueuzian HS,Chen PS,Chen LS

    更新日期：2004-03-03 00:00:00

  • Doppler and two-dimensional echocardiographic diagnosis of Björk-Shiley prosthetic valve malfunction: importance of interventricular septal motion and the timing of onset of valve flow.

    abstract：:In a 69 year old woman with a "sticking" Björk-Shiley mitral prosthesis, the diagnosis was suggested by both the two-dimensional and the Doppler ultrasound examinations. In particular, the findings of early diastolic paradoxic septal motion, intermittent delayed opening of the prosthetic disc and variable timing of th...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(86)80443-0

    authors： Mann DL,Gillam LD,Marshall JE,King ME,Weyman AE

    更新日期：1986-10-01 00:00:00

  • Cardiovascular complications of thrombolytic therapy in patients with a mistaken diagnosis of acute myocardial infarction.

    abstract：:Thrombolytic drugs given to patients with a mistaken diagnosis of acute myocardial infarction could produce adverse effects, although no such cases have been reported. Two patients treated with intravenous streptokinase for presumed but nonexistent acute myocardial infarction are described. Pericardial tamponade devel...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(89)90402-6

    authors： Blankenship JC,Almquist AK

    更新日期：1989-11-15 00:00:00

  • Application of cine nuclear magnetic resonance imaging for sequential evaluation of response to angiotensin-converting enzyme inhibitor therapy in dilated cardiomyopathy.

    abstract：:Cine nuclear magnetic resonance (NMR) imaging was used to serially measure cardiovascular function in 17 patients with New York Heart Association class II or III heart failure and left ventricular ejection fraction less than or equal to 45% who were treated for 3 months with benazepril hydrochloride, a new angiotensin...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(92)90337-m

    authors： Doherty NE 3rd,Seelos KC,Suzuki J,Caputo GR,O'Sullivan M,Sobol SM,Cavero P,Chatterjee K,Parmley WW,Higgins CB

    更新日期：1992-05-01 00:00:00

  • Low Diastolic Blood Pressure Is Associated With Angina in Patients With Chronic Coronary Artery Disease.

    abstract：BACKGROUND:In patients with coronary artery disease (CAD), low diastolic blood pressure (DBP) is associated with increased risk of myocardial infarction, but its association with angina is unknown. OBJECTIVES:The goal of this study was to examine the association of low DBP and angina in patients with CAD. METHODS:The...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2018.05.075

    authors： Peri-Okonny PA,Patel KK,Jones PG,Breeding T,Gosch KL,Spertus JA,Arnold SV

    更新日期：2018-09-11 00:00:00

  • Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia.

    abstract：BACKGROUND:The time course and extent of recovery after revascularization of viable dysfunctional myocardium are variable. Although fibrosis is a major determinant, myocyte structural and molecular remodeling may also play important roles. OBJECTIVES:This study sought to determine whether persistent myocyte loss and/o...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2014.11.040

    authors： Page BJ,Banas MD,Suzuki G,Weil BR,Young RF,Fallavollita JA,Palka BA,Canty JM Jr

    更新日期：2015-02-24 00:00:00

  • Changing strategies in the management of heart failure.

    abstract：:Forty years ago therapy for congestive heart failure was limited largely to the mercurial diuretics and a variety of cardiac glycoside preparations; these were often ineffective, and the common practice of "pushing" digitalis caused serious, sometimes lethal side effects. Today, a more complete understanding of the re...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0735-1097(89)90586-x

    authors： Katz AM

    更新日期：1989-03-01 00:00:00

  • Contemporary Outcomes in Patients With Long QT Syndrome.

    abstract：BACKGROUND:Long QT syndrome (LQTS) is a potentially lethal cardiac channelopathy with a 1% to 5% annual risk of LQTS-triggered syncope, aborted cardiac arrest, or sudden cardiac death. OBJECTIVES:This study sought to evaluate LQTS outcomes from a single center in the contemporary era. METHODS:The authors conducted a ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2017.05.046

    authors： Rohatgi RK,Sugrue A,Bos JM,Cannon BC,Asirvatham SJ,Moir C,Owen HJ,Bos KM,Kruisselbrink T,Ackerman MJ

    更新日期：2017-07-25 00:00:00

  • A comparison of the clinical impact of bleeding measured by two different classifications among patients with acute coronary syndromes.

    abstract：OBJECTIVES:The goal of this study was to determine the association between Thrombolysis In Myocardial Infarction (TIMI) and Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) bleeding and clinical outcomes. BACKGROUND:There are limited data on the relative utility of either scale at predicting clinica...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.09.060

    authors： Rao SV,O'Grady K,Pieper KS,Granger CB,Newby LK,Mahaffey KW,Moliterno DJ,Lincoff AM,Armstrong PW,Van de Werf F,Califf RM,Harrington RA

    更新日期：2006-02-21 00:00:00

  • Do associations with C-reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?

    abstract：OBJECTIVES:We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI). BACKGROUND:Renal insufficiency and renal failure (RF) have been associated with increased cardiovascula...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(03)00564-3

    authors： Zebrack JS,Anderson JL,Beddhu S,Horne BD,Bair TL,Cheung A,Muhlestein JB,Intermountain Heart Collaborative Study Group.

    更新日期：2003-07-02 00:00:00

  • Impact of delay to angioplasty in patients with acute coronary syndromes undergoing invasive management: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial.

    abstract：OBJECTIVES:The aim of this study was to determine the impact of delay to angioplasty in patients with acute coronary syndromes (ACS). BACKGROUND:There is a paucity of data on the impact of delays to percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) u...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2009.11.063

    authors： Sorajja P,Gersh BJ,Cox DA,McLaughlin MG,Zimetbaum P,Costantini C,Stuckey T,Tcheng JE,Mehran R,Lansky AJ,Grines CL,Stone GW

    更新日期：2010-04-06 00:00:00

  • Influence of wall stress and left ventricular geometry on the accuracy of dobutamine stress echocardiography.

    abstract：OBJECTIVE:The goal of this study was to determine whether wall stress at rest and during stress could explain the influence of left ventricular (LV) morphology on the accuracy of dobutamine stress echocardiography (DSE). BACKGROUND:The sensitivity of DSE appears to be reduced in patients with concentric remodeling, bu...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02105-8

    authors： Yuda S,Khoury V,Marwick TH

    更新日期：2002-10-02 00:00:00

  • Effect of three-dimensional valve shape on the hemodynamics of aortic stenosis: three-dimensional echocardiographic stereolithography and patient studies.

    abstract：OBJECTIVES:This study tested the hypothesis that the impact of a stenotic aortic valve depends not only on the cross-sectional area of its limiting orifice but also on three-dimensional (3D) valve geometry. BACKGROUND:Valve shape can potentially affect the hemodynamic impact of aortic stenosis by altering the ratio of...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02269-6

    authors： Gilon D,Cape EG,Handschumacher MD,Song JK,Solheim J,VanAuker M,King ME,Levine RA

    更新日期：2002-10-16 00:00:00

  • Rupture of a left ventricular papillary muscle during acute myocardial infarction: analysis of 22 necropsy patients.

    abstract：:Certain clinical and cardiac morphologic findings are described in 22 patients, aged 45 to 80 years (mean 64) (15 men [68%]), in whom rupture of a papillary muscle occurred during acute myocardial infarction. In most, the acute infarction associated with papillary muscle rupture was a first coronary event (only 18% ha...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(86)80182-6

    authors： Barbour DJ,Roberts WC

    更新日期：1986-09-01 00:00:00

  • Artificial Intelligence in Precision Cardiovascular Medicine.

    abstract：:Artificial intelligence (AI) is a field of computer science that aims to mimic human thought processes, learning capacity, and knowledge storage. AI techniques have been applied in cardiovascular medicine to explore novel genotypes and phenotypes in existing diseases, improve the quality of patient care, enable cost-e...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2017.03.571

    authors： Krittanawong C,Zhang H,Wang Z,Aydar M,Kitai T

    更新日期：2017-05-30 00:00:00

  • Prognostic value of midregional pro-adrenomedullin in patients with acute myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) study.

    abstract：OBJECTIVES:This study sought to assess the prognostic impact of midregional pro-adrenomedullin (MR-proADM) after an acute myocardial infarction (AMI). BACKGROUND:Adrenomedullin (ADM) is elevated in heart failure (HF) and after AMI. Another part of its precursor, MR-proADM, is more stable in circulation and ex vivo. We...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2006.12.038

    authors： Khan SQ,O'Brien RJ,Struck J,Quinn P,Morgenthaler N,Squire I,Davies J,Bergmann A,Ng LL

    更新日期：2007-04-10 00:00:00

  • Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome.

    abstract：OBJECTIVES:In a computed tomographic (CT) angiography study, we identified the characteristics of atherosclerotic lesions that were associated with subsequent development of acute coronary syndrome (ACS). BACKGROUND:The CT characteristics of culprit lesions in ACS include positive vessel remodeling (PR) and low-attenu...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2009.02.068

    authors： Motoyama S,Sarai M,Harigaya H,Anno H,Inoue K,Hara T,Naruse H,Ishii J,Hishida H,Wong ND,Virmani R,Kondo T,Ozaki Y,Narula J

    更新日期：2009-06-30 00:00:00

  • Enhanced T-helper-1 lymphocyte activation patterns in acute coronary syndromes.

    abstract：OBJECTIVES:We sought to determine whether different stages of coronary artery disease (CAD) are associated with distinct differentiation patterns of activated T cells. BACKGROUND:Atherosclerosis is an inflammatory disease. However, little is known about specific inflammatory cell activation in atherosclerosis, for exa...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.03.040

    authors： Methe H,Brunner S,Wiegand D,Nabauer M,Koglin J,Edelman ER

    更新日期：2005-06-21 00:00:00

  • Long-term outcomes of older diabetic patients after percutaneous coronary stenting in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.

    abstract：OBJECTIVES:The purpose of this study was to characterize long-term outcomes of percutaneous coronary intervention (PCI) in elderly diabetic patients in routine practice. BACKGROUND:Although drug-eluting stent (DES) implantation in diabetic patients is common practice, pivotal randomized trials enrolled <2,500 diabetic...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2012.08.993

    authors： Hillegass WB,Patel MR,Klein LW,Gurm HS,Brennan JM,Anstrom KJ,Dai D,Eisenstein EL,Peterson ED,Messenger JC,Douglas PS

    更新日期：2012-12-04 00:00:00

  • Effect of Evolocumab on Complex Coronary Disease Requiring Revascularization.

    abstract：OBJECTIVES:This study sought to evaluate the ability of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab to reduce the risk of complex coronary atherosclerosis requiring revascularization. BACKGROUND:PCSK9 inhibitors induce plaque regression and reduce the risk of coronary revascularizati...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2020.11.011

    authors： Oyama K,Furtado RHM,Fagundes A Jr,Zelniker TA,Tang M,Kuder J,Murphy SA,Hamer A,Wang H,Keech AC,Giugliano RP,Sabatine MS,Bergmark BA

    更新日期：2021-01-26 00:00:00