Abstract：
:Human and porcine cysticercosis is a parasitic disease caused by the larval stage (cysts) of the tapeworm Taenia solium. Cysts may live in several host tissues such as skeletal muscle or brain. We have previously described the presence of host haptoglobin (Hp) and hemoglobin (Hb) in different protein extracts of the T. solium cysts. Here, we report the binding of host Hp and Hb to a number of cyst proteins, evaluated through measuring electrophoretic and light absorbance changes. In the sera obtained from 18 cysticercotic pigs, Hp-Hb complexes were abundant, whereas free Hp was undetectable. In contrast, in the sera from non 18 cysticercotic pigs, Hp-Hb and free Hp were found. In the soluble protein fraction of cysts tissue, free Hp was detected showing a considerable Hb-binding ability, whereas in the vesicular fluid, Hp is mainly bound to Hb. Interestingly, assays carried out with the insoluble fraction of T. solium cysts tissue, showed binding of Hp and Hp-Hb in a saturable way, suggesting the existence of specific interactions. Our results suggested that the parasite can take advantage of the uptaken host Hp and Hb, either free or in complexes, as a source of iron or as a way to modulate the inflammatory response surrounding the T. solium cysts.
journal_name
Mol Biochem Parasitoljournal_title
Molecular and biochemical parasitologyauthors
Navarrete-Perea J,Toledano-Magaña Y,De la Torre P,Sciutto E,Bobes RJ,Soberón X,Laclette JPdoi
10.1016/j.molbiopara.2016.05.010subject
Has Abstractpub_date
2016-06-01 00:00:00pages
61-7issue
2eissn
0166-6851issn
1872-9428pii
S0166-6851(16)30061-5journal_volume
207pub_type
杂志文章abstract：:The exosome, a complex of 3'-exoribonucleases and associated proteins, is involved in the degradation of eukaryotic mRNAs in the cytoplasm, and has RNA processing and quality control functions in the nucleus. In yeast, the nuclear exosome differs from the cytoplasmic one in that it contains an additional non-essential...
journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
doi：10.1016/j.molbiopara.2004.11.003
更新日期：2005-02-01 00:00:00
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
doi：10.1016/s0166-6851(97)00152-7
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journal_title：Molecular and biochemical parasitology
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
doi：10.1016/0166-6851(94)00138-3
更新日期：1994-10-01 00:00:00
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
doi：10.1016/s0166-6851(03)00055-0
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pub_type： 杂志文章
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journal_title：Molecular and biochemical parasitology
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pub_type： 杂志文章
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
doi：10.1016/0166-6851(96)02673-4
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
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更新日期：1994-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0166-6851(99)00110-3
更新日期：1999-09-20 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-6851(94)00156-1
更新日期：1994-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Molecular and biochemical parasitology
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：Molecular and biochemical parasitology
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
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journal_title：Molecular and biochemical parasitology
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Molecular and biochemical parasitology
pub_type： 杂志文章
doi：10.1016/j.molbiopara.2006.02.008
更新日期：2006-06-01 00:00:00
