当前位置： SCI文献检索 > MARINE POLLUTION BULLETIN期刊下所有文献 > Biomarker responses of Cu-induced toxicity in European seabass Dicentrarchus labrax: Assessing oxidative stress and histopathological alterations.

Biomarker responses of Cu-induced toxicity in European seabass Dicentrarchus labrax: Assessing oxidative stress and histopathological alterations.

Abstract：

:A comprehensive approach to chemical accumulation and biological effects of short-term Cu exposure in juveniles of European seabass (Dicentrarchus labrax) has been achieved. Fish were exposed to 0.01-10mgL-1 nominal Cu concentrations for 24-96h. Metal concentrations in water and gills, liver, muscle and brain tissues were studied along with oxidative stress biomarkers (superoxide dismutase, catalase, glutathione peroxidase, lipid peroxidation). Induction of oxidative damage was observed in all the organs with differential antioxidant responses; gills appearing as the most sensitive from low environmentally water Cu concentrations as 0.01mgL-1. Histopathological alterations were also observed in liver and gills, even without a significant Cu accumulation. The results show that the combination of oxidative stress parameters, particularly lipid peroxidation and glutathione peroxidase activities, and histopathological alterations provide a good model fish and reliable early biomarkers for monitoring Cu pollution in seawater and might call for the protection agencies to revise the Cu environmental standards.

journal_name

Mar Pollut Bull

journal_title

Marine pollution bulletin

authors

Díaz-de-Alba M,Canalejo Raya A,Granado-Castro MD,Oliva Ramírez M,El Mai B,Córdoba García F,Troyano-Montoro M,Espada-Bellido E,Torronteras Santiago R,Galindo-Riaño MD

doi

10.1016/j.marpolbul.2017.07.039

subject

Has Abstract

pub_date

2017-11-15 00:00:00

pages

336-348

issue

1

eissn

0025-326X

issn

1879-3363

pii

S0025-326X(17)30620-3

journal_volume

124

pub_type

杂志文章

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