Abstract:
:This paper investigates cell proliferation dynamics in small tumor cell aggregates using an individual-based model (IBM). The simulation model is designed to study the morphology of the cell population and of the cell lineages as well as the impact of the orientation of the division plane on this morphology. Our IBM model is based on the hypothesis that cells are incompressible objects that grow in size and divide once a threshold size is reached, and that newly born cell adhere to the existing cell cluster. We performed comparisons between the simulation model and experimental data by using several statistical indicators. The results suggest that the emergence of particular morphologies can be explained by simple mechanical interactions.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Leroy-Lerêtre M,Dimarco G,Cazales M,Boizeau ML,Ducommun B,Lobjois V,Degond Pdoi
10.1007/s11538-017-0333-ysubject
Has Abstractpub_date
2017-10-01 00:00:00pages
2356-2393issue
10eissn
0092-8240issn
1522-9602pii
10.1007/s11538-017-0333-yjournal_volume
79pub_type
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