Renal toxicity of nanoparticles of cadmium sulphide in rat.

Abstract:

:During present investigations, renal toxicity of CdSNPs (cadmium sulphide nanoparticles) (ranged 5-9 nm) was estimated in rat employing specific parameters. Treatment on each alternate day for 45 days with CdSNPs (10 mg/kg b.w.) yielded significant increase in Cd-MT (cadmium metallothionein), lipid peroxidation and H2O2 generation in the kidney of rat in comparison to bulk cadmium. Concentration of creatinine also increased in urine of CdSNPs treated rats. Histopathological observations revealed extensive damage in proximal tubules. Ultrastructural studies showed mitochondrial, nuclear and ER (endoplasmic reticulum) changes. Finally, renal toxicity of CdSNPs was confirmed by loss of alkaline phosphatase from the brush border of proximal convoluted tubules. These observations conclude that CdSNPs manifest greater toxicity in kidney than cadmium sulphide bulk particles. These effects have been attributed to their specific physicochemical properties, greater potential to generate ROS and induction of oxidative stress and impairment of renal structure and function. Present observations suggest that commercial/industrial use of CdSNPs may pose serious renal health problems in man.

journal_name

Chemosphere

journal_title

Chemosphere

authors

Rana K,Verma Y,Rani V,Rana SVS

doi

10.1016/j.chemosphere.2017.11.011

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

142-150

eissn

0045-6535

issn

1879-1298

pii

S0045-6535(17)31771-X

journal_volume

193

pub_type

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