Abstract：
:Increasing studies have established the toxic effects of BPA on development and reproduction in animals. In present study, we investigated epigenetic effects on the transcription of several ovarian steroidogenic genes in rare minnows Gobiocypris rarus after BPA exposure at 15 μgL-1 for 21, 42 and 63 d. Results showed that short term BPA exposure (21 d) caused significant increase of both estradiol and testerone levels whereas long term exposure (63 d) led to significant decrease of them. The oocytes development was hindered after BPA exposure. BPA treatments for 21 and 42 d resulted in significant increase of genome DNA methylation in ovary while 63-d exposure caused marked decrease. The histone trimethylation levels (H3K4me3, H3K9me3 and H3K27me3) in the ovary were also disturbed by BPA. H3K9me3 was significantly decreased after 21 d whereas it was markedly increased after 42 and 63 d. The 42-d exposure caused significant decrease for H3K4me3. Meanwhile, 42- and 63-d BPA exposure led to significant decrease of H3K27me3. DNA methylation could involve in gene expression regulation of cyp17a1 and cyp19a1a after BPA exposure. After short (21 d) and long term (63 d) BPA exposure, the respective mRNA expression down-regulation and up-regulation of star, cyp11a1, and cyp17a1 were mediated by H3K9me3. This study suggests that epigenetic modulation including DNA and histone methylation could be responsible for the detrimental effects on ovary development upon BPA exposure in G. rarus. It is speculated that BPA exposures for short or long term duration could disturb the steroidogenesis in entirely different mechanisms.
journal_name
Chemospherejournal_title
Chemosphereauthors
Liu Y,Wang L,Zhu L,Ran B,Wang Zdoi
10.1016/j.chemosphere.2019.124935subject
Has Abstractpub_date
2020-02-01 00:00:00pages
124935eissn
0045-6535issn
1879-1298pii
S0045-6535(19)32174-5journal_volume
240pub_type
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