Abstract:
:This study demonstrates that increased NADPH production can improve biomass and ethanol production in cyanobacteria. We over-expressed the endogenous zwf gene, which encodes glucose-6-phosphate dehydrogenase of pentose phosphate pathway, in the model cyanobacterium Synechocystis sp. PCC 6803. zwf over-expression resulted in increased NADPH production, and promoted biomass production compared to the wild type in both autotrophic and mixotrophic conditions. Ethanol production pathway including NADPH-dependent alcohol dehydrogenase was also integrated with and without zwf over-expression. Excessive NADPH production by zwf over-expression could improve both biomass and ethanol production in the autotrophic conditions.
journal_name
Bioresour Technoljournal_title
Bioresource technologyauthors
Choi YN,Park JMdoi
10.1016/j.biortech.2016.02.056subject
Has Abstractpub_date
2016-08-01 00:00:00pages
54-57eissn
0960-8524issn
1873-2976pii
S0960-8524(16)30189-4journal_volume
213pub_type
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