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Isatin derivatives with activity against apoptosis-resistant cancer cells.

Abstract：

:In a search of small molecules active against apoptosis-resistant cancer cells, a series of isatin-based heterocyclic compounds were synthesized and found to inhibit proliferation of cancer cell lines resistant to apoptosis. The synthesis of these compounds involved a condensation of commercially available, active methylene heterocycles with isatin proceeding in moderate to excellent yields. The heterocyclic scaffolds prepared in the current investigation appear to be a useful starting point for the development of agents to fight cancers with apoptosis resistance, and thus, associated with dismal prognoses.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Evdokimov NM,Magedov IV,McBrayer D,Kornienko A

doi

10.1016/j.bmcl.2016.02.015

subject

Has Abstract

pub_date

2016-03-15 00:00:00

pages

1558-1560

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(16)30118-4

journal_volume

26

pub_type

杂志文章

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