Oral administration of the prostaglandin enisoprost induces uterine activity and softens the cervix during first trimester pregnancy.

Abstract:

:48 patients in the first trimester of pregnancy received a single oral dose of placebo or enisoprost (prostaglandin E1 analogue): 10, 25, 50, 100, 200 or 400 micrograms. Uterine activity was recorded for 1 h before and for 4 h after administration of the study drug with a Millar microtransducer. There was a dose-related increase in mean resting and active pressure, but not in frequency of pressure cycles. At the highest dose used, namely 400 micrograms, all 6 subjects bled. Enisoprost dilated the cervix and any further dilatation required was easy to accomplish.

authors

Pulkkinen MO,Cohen H,Vuento M

doi

10.3109/00016348909009903

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

149-52

issue

2

eissn

0001-6349

issn

1600-0412

journal_volume

68

pub_type

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