Abstract:
INTRODUCTION:Endometriosis is associated with hyperperistalsis and dysperistalsis in the uterus, and it has been shown that progesterone leads to a decrease in uterine contractility. The synthetic gestagen dienogest is often administered in women who are receiving conservative treatment for endometriosis, and it may be the treatment of choice. The present study investigated the effects of dienogest on uterine contractility in comparison with the known inhibitory effect of progesterone. MATERIAL AND METHODS:Eighty swine uteri were examined using an established extracorporeal perfusion model. The uteri were perfused for at least 4 hours with progesterone, dienogest, or a modified Krebs-Ringer solution as the control group, with uterine contractions being measured using an intrauterine microchip catheter. The amplitude and frequency of contractions and the area under the curve (AUC), reflecting overall contractility, were measured at two separate locations (the isthmus and fundus). RESULTS:Progesterone led to a significant decrease in the amplitude of uterine contractions and to reduced overall pressure (AUC) at the isthmus and fundus. Dienogest led to a significant decrease in the amplitude of contractions and overall pressure (AUC) in the area of the isthmus, but the decrease near the fundus was not significant. The frequency of uterine contractions was not influenced by either progesterone or dienogest. CONCLUSIONS:These results confirm the known inhibitory effect of progesterone on uterine contractility (relative to amplitude of contractions and overall contractility), affecting the whole organ. Perfusion of the uterus with dienogest also led to a general decrease in uterine contractility similar to the effect of progesterone.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Oppelt PG,Weber M,Mueller A,Boosz A,Hoffmann I,Raffel N,Lotz L,Beckmann MW,Dittrich Rdoi
10.1111/aogs.13428subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1293-1299issue
11eissn
0001-6349issn
1600-0412journal_volume
97pub_type
杂志文章abstract::Using the registration of all pregnant women living within a particular geographical district of Copenhagen the risk of spontaneous abortion has been calculated by means of a decremental method. A total of 3,042 pregnancies were registered and the total risk of spontaneous abortion was calculated at 10 per cent. In 43...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348009154629
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:To investigate the relation between pelvic floor muscle strength and sexual function among women with higher and lower pelvic floor muscle strength. DESIGN:A cross-sectional study was performed among employees and students of the University. SETTING:Urogynecology department, Federal University of Pampa, Bra...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12379
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:Exposure to intimate partner violence (IPV) has been found to be associated with a multitude of poor health and quality of life outcomes. Among the risks exacerbated by IPV is prenatal depression. Resilience is hypothesized to protect against psychopathology after exposure to a traumatic influence. The pre...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.14062
更新日期:2020-12-14 00:00:00
abstract:OBJECTIVE:To study local treatment of ectopic pregnancy by injection of hyperosmolar (50%) glucose, guided either by transvaginal ultrasound or by laparoscopy. METHODS:Eighty women were randomized, 39 into the sonography and 41 into the laparoscopy group. Criteria for inclusion were 1) ectopic pregnancy < or = 4 cm se...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016349509013476
更新日期:1995-09-01 00:00:00
abstract::We have analysed the duration of pregnancy for singleton births in Sweden during 1976-80 by means of data from the Swedish Birth Registry. Information, which was obtained from special forms with standard questions, include date of first day of last menstrual period (LMP) and whether that date was considered reliable o...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349009028681
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:To evaluate the relationship between the severity of dysmenorrhea and endometrioma. METHODS:Descriptive study with prospective design. Two hundred and thirty-nine women with histologically proved endometriomas. The severity of dysmenorrhea was assessed prospectively with a 10-cm visual analog scale. Various...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340600935490
更新日期:2006-01-01 00:00:00
abstract::Intramuscular 15(S)15 methyl PGF2α (Prostin 15M, Upjohn) was used for induction of labour in cases of missed abortion and intra-uterine fetal death. The patients received premedication to control the gastrointestinal side effects. Prostin 15M was given at a dose of 250 µg every three hours and escalated whenever requi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.1988.67.s145.45
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the impact of tension-free vaginal tape (TVT) procedure as anti-incontinence surgery on patients' urinary symptoms and quality of life. METHODS:Ninety-eight patients participated in the study. All patients were operated for urodynamic stress incontinence with the TVT proce...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340600603759
更新日期:2006-01-01 00:00:00
abstract::A previously developed mathematical formula for prediction of fetal growth deviation at birth by means of ultrasonic fetometry was applied to 505 unselected singleton pregnancies. The gestational age was assessed by measuring the fetal biparietal diameter (BPD) in the 17th week of pregnancy. In the 33rd and 38th week ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348309155774
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:To compare a 48 hour non surgical policy in the management of spontaneous abortion with a policy of routine, universal uterine curettage. METHODS:A prospective, observational study on 354 women admitted to hospital with spontaneous abortion. Of these, 225 who had retained products of conception were treated...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVES:To estimate the prevalence of fungi in the vagina, rectum and oral cavity in pregnant women with diabetes mellitus (DM) type I or gestational diabetes mellitus (GDM) and in healthy controls; to assess the influence of gestational age on the prevalence of fungi; to compare the vaginal symptoms within the grou...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.0361.x
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Induction of labor has been associated with an increased risk of emergency cesarean delivery. Knowledge of factors that influence the risk of cesarean delivery in women with induced labor is limited. METHODS:We performed a case-control study, nested within a population-based cohort of women with induced lab...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2005.00620.x
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To study the frequency and determinants of potentially avoidable planned cesarean sections, with a classification based on their indications, maternal obstetric history, and information about the current pregnancy. DESIGN:Cross-sectional population-based study. SETTING:All maternity units in France (n = 535...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12439
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To study whether increased maternal weight and other factors of importance is associated with higher birth weights of the children over a period of almost 25 years. DESIGN:Retrospective cohort study. SETTING:Delivery wards in southeast Sweden. SAMPLE:A total of 4,330 delivered women and their children from...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902807199
更新日期:2009-01-01 00:00:00
abstract::Plasma antithrombin III (AT III) was studied longitudinally in 15 subjects (13 patients and 2 volunteers), who used the "morning-after pill" (5 mg ethinylestradiol daily for 5 days). The mean decrease in AT III level in the 13 patients was 17% of the pre-treatment value. From additional observations made in 2 of the p...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348309156240
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:The aim was to construct a new symphysis-fundus (SF) height growth chart, based on ultrasound-dated singleton pregnancies. METHODS:We made a population-based study of all women, from the catchment areas of three district antenatal clinics, who registered for antenatal care during 1986. The growth of the SF ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349509021174
更新日期:1995-10-01 00:00:00
abstract::Uterine activity was measured quantitatively during subsequent labor after prostaglandin E2 gel (PGE2). Thirty primigravidae with a low Bishop score were included in this randomized double-blind study. Fewer women who received PGE2 required subsequent surgical induction. The pattern of uterine activity was different. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016348509154683
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To investigate the frequency of lumbosacral pains and sacroiliitis as late sequela of severe pelvic inflammatory disease (PID) confirmed by laparoscopy or laparotomy. DESIGN:The sacroiliac joints were examined radiographically and scintigraphically to search for signs of reactive sacroiliitis. SETTING:Depar...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349409015772
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:Sonographic training in obstetrics differs broadly in Germany, although there are clearly defined quality-oriented requirements. In order to improve professional education, a training concept was devised utilizing an ultrasound simulator system. DESIGN:Between October 2004 and May 2006, 100 obstetric ultraso...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016340903280941
更新日期:2010-03-01 00:00:00
abstract::Ovarian cancer patients in whom complete tumor removal is impossible with primary debulking surgery (PDS) may benefit from neoadjuvant chemotherapy and interval debulking surgery. However, the task of performing a pre-operative evaluation of the feasibility of PDS is difficult. We aimed to investigate whether the risk...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12127
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To evaluate whether we could accurately predict lymph node (LN) metastasis with preoperative tests in endometrial cancer. Design. Retrospective study. SETTING:Seoul National University Hospital, South Korea. Population. Three hundred patients with endometrial cancer who underwent surgical staging including l...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016340903370114
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The accuracy of ultrasound in the diagnosis of congenital malformations has been the subject of many studies. Most of these are hospital-based studies over a limited period of years presenting high detection rates and also relatively high incidence of major malformations. We present here a large population-b...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340600676474
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to study whether the associations of maternal body mass index with offspring birthweight and placental weight differ by maternal diabetes status. MATERIAL AND METHODS:We performed a population study of 106 191 singleton pregnancies by using data from the years 2009-2012 in the Me...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12947
更新日期:2016-10-01 00:00:00
abstract::Among a group of 249 women examined during 1969-1971 in Swedish hospitals because of amenorrhea after oral contraceptive therapy, 177 patients answered a follow-up questionnaire in April 1972. For purposes of study these latter patients were divided into Groups 1 (6-12 month amenorrhea, spontaneous recovery), 2 (12-3...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347309157095
更新日期:1973-01-01 00:00:00
abstract:INTRODUCTION:Gynecological cancer patients are routinely followed up for five years after primary treatment. However, the value of such follow up has been debated, as retrospective studies indicate that first recurrence is often symptomatic and occurs within two to three years of primary treatment. We prospectively inv...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13199
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To explore procedures for providing information, assessment and documentation about ultrasound soft markers in Sweden. DESIGN:Descriptive, quantitative, cross-sectional survey. SAMPLE:Eighty-two percent of all obstetric ultrasound clinics in Sweden (covering >90% of routine fetal ultrasound examinations). ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12554
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:The use of self-report as a strategy for collecting data on women's weight and height is widespread in both clinical practice and epidemiological studies. This study aimed to compare self-reported and directly measured weight and height among women of reproductive age. MATERIAL AND METHODS:In July 2015 we...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/aogs.13326
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To provide an epidemiological description of the use of ultrasound in obstetrics in Denmark and to analyse whether screening per se reduces the mean number of obstetric ultrasound examinations for all pregnant women. DESIGN:Questionnaire study based on hospital records and patient interviews. SETTING:All Da...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349209041442
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To investigate the risk for anal sphincter tears (AST) in infibulated women. DESIGN:Population-based cohort study. SETTING:Nationwide study in Sweden. POPULATION:The study population included 250 491 primiparous women with a vaginal singleton birth at 37-41 completed gestational weeks during 1999-2008. We ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12010
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:More than 30 000 legal abortions are performed every year in Sweden despite sexual education in schools, widespread youth-clinics and family planning services that are free of charge. The aim of this study was to investigate reasons for induced abortion, contraceptive habits and reasons for contraceptive fai...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1046/j.0001-6349.2001.00169.x
更新日期:2002-01-01 00:00:00