Fas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus.

abstract：:Flk2/Flt3 is a recently identified receptor tyrosine kinase expressed in brain, placenta, testis, and primitive hematopoietic cells. The mitogenic signalling potential and biochemical properties of Flk2/Flt3 have been analyzed by using a chimeric receptor composed of the extracellular domain of the human colony-stimul...

journal_title：Molecular and cellular biology

authors： Dosil M,Wang S,Lemischka IR

更新日期：1993-10-01 00:00:00

abstract：:The yeast protein Spa2p localizes to growth sites and is important for polarized morphogenesis during budding, mating, and pseudohyphal growth. To better understand the role of Spa2p in polarized growth, we analyzed regions of the protein important for its function and proteins that interact with Spa2p. Spa2p interact...

journal_title：Molecular and cellular biology

authors： Sheu YJ,Santos B,Fortin N,Costigan C,Snyder M

更新日期：1998-07-01 00:00:00

abstract：:To analyze determinants within the Na,K-ATPase alpha subunit that contribute to differential ouabain sensitivity, we constructed and expressed a panel of chimeric cDNA molecules between ouabain-resistant and ouabain-sensitive alpha subunit cDNAs. When introduced into ouabain-sensitive monkey CV-1 cells, ouabain-resist...

journal_title：Molecular and cellular biology

authors： Emanuel JR,Graw S,Housman D,Levenson R

更新日期：1989-09-01 00:00:00

abstract：:It is thought that degradation of nuclear proteins by the ubiquitylation system requires nuclear-cytoplasmic trafficking of E3 ubiquitin ligases. The von Hippel-Lindau (VHL) tumor suppressor protein is the substrate recognition component of a Cullin-2-containing E3 ubiquitin ligase that recruits hypoxia-inducible fact...

journal_title：Molecular and cellular biology

authors： Khacho M,Mekhail K,Pilon-Larose K,Payette J,Lee S

更新日期：2008-01-01 00:00:00

abstract：:Human myeloid leukemia cells respond to 12-O-tetradecanoylphorbol-13-acetate (TPA) and other activators of protein kinase C (PKC) with induction of monocytic differentiation. The present studies demonstrated that treatment of U-937 and HL-60 myeloid leukemia cells with TPA, phorbol-12,13-dibutyrate, or bryostatin 1 wa...

journal_title：Molecular and cellular biology

authors： Kaneki M,Kharbanda S,Pandey P,Yoshida K,Takekawa M,Liou JR,Stone R,Kufe D

更新日期：1999-01-01 00:00:00

abstract：:Polycomb repressive complexes (PRCs) are important chromatin regulators of embryonic stem (ES) cell function. RYBP binds Polycomb H2A monoubiquitin ligases Ring1A and Ring1B and has been suggested to assist PRC localization to their targets. Moreover, constitutive inactivation of RYBP precludes ES cell formation. Usin...

journal_title：Molecular and cellular biology

authors： Hisada K,Sánchez C,Endo TA,Endoh M,Román-Trufero M,Sharif J,Koseki H,Vidal M

更新日期：2012-03-01 00:00:00

abstract：:The CDC8 gene, whose product is required for DNA replication in Saccharomyces cerevisiae, has been isolated on recombinant plasmids. The yeast vector YCp50 bearing the yeast ARS1, CEN4, and URA3 sequences, to provide for replication, stability, and selection, respectively, was used to prepare a recombinant plasmid poo...

journal_title：Molecular and cellular biology

authors： Kuo CL,Campbell JL

更新日期：1983-10-01 00:00:00

abstract：:Inactivation of the tumor suppressor p53 by degradation is a mechanism utilized by cells to adapt to endoplasmic reticulum (ER) stress. However, the mechanisms of p53 destabilization by ER stress are not known. We demonstrate here that the E3 ubiquitin-ligase Hdm2 is essential for the nucleocytoplasmic transport and p...

journal_title：Molecular and cellular biology

authors： Pluquet O,Qu LK,Baltzis D,Koromilas AE

更新日期：2005-11-01 00:00:00

abstract：:The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor disrupted in patients with t(11;17)(q23;q21)-associated acute promyelocytic leukemia. PLZF contains an N-terminal BTB/POZ domain which is required for dimerization, transcriptional repression, formation of high-molecular-weight DNA-protein...

journal_title：Molecular and cellular biology

authors： Melnick A,Ahmad KF,Arai S,Polinger A,Ball H,Borden KL,Carlile GW,Prive GG,Licht JD

更新日期：2000-09-01 00:00:00

abstract：:IME1 encodes a transcriptional activator required for the transcription of meiosis-specific genes and initiation of meiosis in Saccharomyces cerevisiae. The transcription of IME1 is repressed in the presence of glucose, and a low basal level of IME1 RNA is observed in vegetative cultures with acetate as the sole carbo...

journal_title：Molecular and cellular biology

authors： Sagee S,Sherman A,Shenhar G,Robzyk K,Ben-Doy N,Simchen G,Kassir Y

更新日期：1998-04-01 00:00:00

abstract：:Expression of the recombinant human U1-70K protein in COS cells resulted in its rapid transport to the nucleus, even when binding to U1 RNA was debilitated. Deletion analysis of the U1-70K protein revealed the existence of two segments of the protein which were independently capable of nuclear localization. One nuclea...

journal_title：Molecular and cellular biology

authors： Romac JM,Graff DH,Keene JD

更新日期：1994-07-01 00:00:00

abstract：:We sought to study the binding constraints placed on the nine-zinc-finger protein transcription factor IIIA (TFIIIA) by a histone octamer. To this end, five overlapping fragments of the Xenopus laevis oocyte and somatic 5S rRNA genes were reconstituted into nucleosomes, and it was subsequently shown that nucleosome tr...

journal_title：Molecular and cellular biology

authors： Howe L,Ausió J

更新日期：1998-03-01 00:00:00

abstract：:In Pichia pastoris, alcohol oxidase (AOX) is the first enzyme in the methanol utilization pathway and is encoded by two genes, AOX1 and AOX2. The DNA and predicted amino acid sequences of the protein-coding portions of the genes are closely homologous, whereas flanking sequences share no homology. The functional roles...

journal_title：Molecular and cellular biology

authors： Cregg JM,Madden KR,Barringer KJ,Thill GP,Stillman CA

更新日期：1989-03-01 00:00:00

abstract：:The message for the zinc finger gene Rex-1 (Zfp-42) is expressed in undifferentiated murine F9 teratocarcinoma cells and embryonic stem cells. Expression of Rex-1 is reduced at the transcriptional level when F9 cells are induced by the addition of retinoic acid (RA) to differentiate. We have isolated genomic DNA for t...

journal_title：Molecular and cellular biology

authors： Hosler BA,Rogers MB,Kozak CA,Gudas LJ

更新日期：1993-05-01 00:00:00

abstract：:We find that during embryogenesis the expression of HMGN1, a nuclear protein that binds to nucleosomes and reduces the compaction of the chromatin fiber, is progressively down-regulated throughout the entire embryo, except in committed but continuously renewing cell types, such as the basal layer of the epithelium. In...

journal_title：Molecular and cellular biology

authors： Furusawa T,Lim JH,Catez F,Birger Y,Mackem S,Bustin M

更新日期：2006-01-01 00:00:00

abstract：:In contrast to differentiated somatic cells, mouse embryonal carcinoma (EC) cell lines spontaneously express high levels of major members of the heat shock protein (HSP) family. In addition, some EC cell lines (noninducible) are not able to induce HSP gene transcription and HSP synthesis after a stress. However, after...

journal_title：Molecular and cellular biology

authors： Mezger V,Bensaude O,Morange M

更新日期：1989-09-01 00:00:00

abstract：:The canonical Notch signaling pathway mediated by Delta- and Jagged-like Notch ligands determines a variety of cell fates in metazoa. In Caenorhabditis elegans and sea urchins, canonical Notch signaling is essential for different cell fate specifications during early embryogenesis or the formation of endoderm, mesoder...

journal_title：Molecular and cellular biology

authors： Shi S,Stahl M,Lu L,Stanley P

更新日期：2005-11-01 00:00:00

abstract：:Nuclear migration and positioning within cells are critical for many developmental processes and are governed by the cytoskeletal network. Although mechanisms of nuclear-cytoskeletal attachment are unclear, growing evidence links a novel family of nuclear envelope (NE) proteins that share a conserved C-terminal SUN (S...

journal_title：Molecular and cellular biology

authors： Haque F,Lloyd DJ,Smallwood DT,Dent CL,Shanahan CM,Fry AM,Trembath RC,Shackleton S

更新日期：2006-05-01 00:00:00

abstract：:A recent analysis of gene expression in renal cell carcinoma cells led to the identification of mRNAs whose translation was dependent on the presence of the von Hippel-Lindau (VHL) tumor suppressor gene product, pVHL. Here, we investigate the finding that pVHL-expressing RCC cells (VHL(+)) exhibited elevated levels of...

journal_title：Molecular and cellular biology

authors： Galbán S,Martindale JL,Mazan-Mamczarz K,López de Silanes I,Fan J,Wang W,Decker J,Gorospe M

更新日期：2003-10-01 00:00:00

abstract：:Using competition mobility shift, methylation interference, and proteolytic clipping DNA binding assays, we demonstrate that the protein binding the major histocompatibility complex A beta CCAAT box is indistinguishable from the protein previously named NF-Y, which binds the major histocompatibility complex E alpha CC...

journal_title：Molecular and cellular biology

authors： Kern MJ,Woodward JG

更新日期：1991-01-01 00:00:00

abstract：:Protein 4.1G is a membrane skeletal protein found in specific subcellular structures in myelinated Schwann cells and seminiferous tubules. Here, we show that in the mouse sciatic nerve, protein 4.1G colocalized at Schmidt-Lanterman incisures (SLI) and the paranodes with a member of the membrane-associated guanylate ki...

journal_title：Molecular and cellular biology

authors： Terada N,Saitoh Y,Ohno N,Komada M,Saitoh S,Peles E,Ohno S

更新日期：2012-01-01 00:00:00

abstract：:We show that the nuclear genes for the cytoplasmic and mitochondrial leucyl-tRNA synthetase (LeuRS) of Neurospora crassa are distinct in their encoded proteins, codon usage, mRNA levels, and regulation. The 4.2-kilobase-pair region representing the structural gene for cytoplasmic LeuRS and flanking regions has been se...

journal_title：Molecular and cellular biology

authors： Chow CM,Rajbhandary UL

更新日期：1989-11-01 00:00:00

abstract：:We recently identified Vav, the product of the vav proto-oncogene, as a guanine nucleotide exchange factor (GEF) for Ras. Vav is enzymatically activated by lymphocyte antigen receptor-coupled protein tyrosine kinases or independently by diglycerides. To further evaluate the physiological role of Vav, we assessed its G...

journal_title：Molecular and cellular biology

authors： Gulbins E,Coggeshall KM,Langlet C,Baier G,Bonnefoy-Berard N,Burn P,Wittinghofer A,Katzav S,Altman A

更新日期：1994-02-01 00:00:00

abstract：:Adipocytes constitute a major part of the bone marrow stroma in vivo and may play an active role in lymphohematopoiesis. Earlier studies had shown that the bone marrow stromal cell clone BMS2 was capable of adipocyte differentiation in vitro, in addition to its well-defined ability to support B lymphopoiesis. We now d...

journal_title：Molecular and cellular biology

authors： Gimble JM,Dorheim MA,Cheng Q,Pekala P,Enerback S,Ellingsworth L,Kincade PW,Wang CS

更新日期：1989-11-01 00:00:00

abstract：:zfh-1 is a member of the zfh family of proteins, which all contain zinc finger and homeodomains. The roles and mechanisms of action of most family members are still unclear. However, we have shown previously that another member of the family, the vertebrate ZEB protein, is a transcriptional repressor that binds E box ...

journal_title：Molecular and cellular biology

authors： Postigo AA,Ward E,Skeath JB,Dean DC

更新日期：1999-10-01 00:00:00

abstract：:Transcription factor-induced reprogramming of somatic cells to pluripotency is mediated via profound alterations in the epigenetic landscape. The histone variant macroH2A1 (mH2A1) is a barrier to the cellular reprogramming process. We demonstrate here that mH2A1 blocks reprogramming and contributes to the preservation...

journal_title：Molecular and cellular biology

authors： Pliatska M,Kapasa M,Kokkalis A,Polyzos A,Thanos D

更新日期：2018-04-30 00:00:00

abstract：:We have characterized two P-element-induced, lethal mutations in Drosophila melanogaster which affect the larval hemocytes, mediators of the insect immune response. Each mutant displays larval melanotic tumors characteristic of mutations affecting the insect cellular immune system, and the moribund animals develop gro...

journal_title：Molecular and cellular biology

authors： Stewart MJ,Denell R

更新日期：1993-04-01 00:00:00

abstract：:The recruitment of transcriptional coactivators, including histone modifying enzymes, is an important step in transcription regulation. A typical activator is thought to interact with several cofactors, presumably in a sequential manner. The common use of several cofactors raises the question of how activators achieve...

journal_title：Molecular and cellular biology

authors： Gamper AM,Roeder RG

更新日期：2008-04-01 00:00:00

abstract：:Schizosaccharomyces pombe Cdc5p and its Saccharomyces cerevisiae ortholog, Cef1p, are essential Myb-related proteins implicated in pre-mRNA splicing and contained within large multiprotein complexes. Here we describe the tandem affinity purification (TAP) of Cdc5p- and Cef1p-associated complexes. Using transmission el...

journal_title：Molecular and cellular biology

authors： Ohi MD,Link AJ,Ren L,Jennings JL,McDonald WH,Gould KL

更新日期：2002-04-01 00:00:00

abstract：:There is scant knowledge regarding how cell surface lipid-anchored T-cadherin (T-cad) transmits signals through the plasma membrane to its intracellular targets. This study aimed to identify membrane proteins colocalizing with atypical glycosylphosphatidylinositol (GPI)-anchored T-cad on the surface of endothelial cel...

journal_title：Molecular and cellular biology

authors： Philippova M,Ivanov D,Joshi MB,Kyriakakis E,Rupp K,Afonyushkin T,Bochkov V,Erne P,Resink TJ

更新日期：2008-06-01 00:00:00