SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.

abstract：:Bona fide apoptosis in rat and human leukemia cells, rat thymocytes, and bovine endothelial cells was accompanied by limited and specific cleavage of polysome-associated and monosome-associated 28S rRNA, with 18S rRNA being spared. Specific 28S rRNA cleavage was observed in all instances of apoptotic death accompanied...

journal_title：Molecular and cellular biology

authors： Houge G,Robaye B,Eikhom TS,Golstein J,Mellgren G,Gjertsen BT,Lanotte M,Døskeland SO

更新日期：1995-04-01 00:00:00

abstract：:The 5' ends of dihydrofolate reductase (DHFR)-specific transcripts have been mapped in the 5'-flanking region of the amplified DHFR gene of the human methotrexate-resistant cell line 6A3 by primer extension and S1 protection experiments. The main 5' end, at position -71 relative to the first nucleotide of the DHFR rea...

journal_title：Molecular and cellular biology

authors： Masters JN,Attardi G

更新日期：1985-03-01 00:00:00

abstract：:Gap junctional intercellular communication is inhibited in response to tumor promoters and oncogene transformation, suggesting that loss of this function is an important step in tumor formation. To elucidate the molecular mechanisms responsible for this inhibition, we examined the expression of gap junction proteins a...

journal_title：Molecular and cellular biology

authors： Brissette JL,Kumar NM,Gilula NB,Dotto GP

更新日期：1991-10-01 00:00:00

abstract：:The PHR1 gene of Saccharomyces cerevisiae encodes a photolyase which repairs specifically and exclusively pyrimidine dimers, the most frequent lesions induced in DNA by far-UV radiation. We have asked whether expression of PHR1 is modulated in response to UV-induced DNA damage and to DNA-damaging agents that induce le...

journal_title：Molecular and cellular biology

authors： Sebastian J,Kraus B,Sancar GB

更新日期：1990-09-01 00:00:00

abstract：:Interleukin-5 (IL-5) and IL-6 have both been reported to act as B-cell differentiation factors by stimulating activated B cells to secrete antibody. However, it has not been possible to directly compare the effects of these two lymphokines because of the lack of a suitable B-cell line capable of responding to both. We...

journal_title：Molecular and cellular biology

authors： Randall TD,Lund FE,Brewer JW,Aldridge C,Wall R,Corley RB

更新日期：1993-07-01 00:00:00

abstract：:Secretory proteins in eukaryotic cells are transported to the cell surface via the endoplasmic reticulum (ER) and the Golgi apparatus by membrane-bounded vesicles. We screened a collection of temperature-sensitive mutants of Saccharomyces cerevisiae for defects in ER-to-Golgi transport. Two of the genes identified in ...

journal_title：Molecular and cellular biology

authors： Chen EJ,Frand AR,Chitouras E,Kaiser CA

更新日期：1998-12-01 00:00:00

abstract：:We utilized the human 4F2 heavy-chain (4F2HC) gene as a model system to study the regulation of inducible gene expression during normal human T-cell activation. Previous studies have demonstrated that 4F2HC gene expression is induced during normal T-cell activation and that the activity of the gene is regulated, at le...

journal_title：Molecular and cellular biology

authors： Karpinski BA,Yang LH,Cacheris P,Morle GD,Leiden JM

更新日期：1989-06-01 00:00:00

abstract：:The niaD and niiA genes of Aspergillus nidulans, which code, respectively, for nitrate and nitrite reductases, are divergently transcribed, and their ATGs are separated by 1,200 bp. The genes are under the control of the positively acting NirA transcription factor, which mediates nitrate induction. The DNA binding dom...

journal_title：Molecular and cellular biology

authors： Punt PJ,Strauss J,Smit R,Kinghorn JR,van den Hondel CA,Scazzocchio C

更新日期：1995-10-01 00:00:00

abstract：:MAP2K4 encodes a dual-specificity kinase (mitogen-activated protein kinase kinase 4, or MKK4) that is mutated in a variety of human malignancies, but the biochemical properties of the mutant kinases and their roles in tumorigenesis have not been fully elucidated. Here we showed that 8 out of 11 cancer-associated MAP2K...

journal_title：Molecular and cellular biology

authors： Ahn YH,Yang Y,Gibbons DL,Creighton CJ,Yang F,Wistuba II,Lin W,Thilaganathan N,Alvarez CA,Roybal J,Goldsmith EJ,Tournier C,Kurie JM

更新日期：2011-11-01 00:00:00

abstract：:The Id subfamily of helix-loop-helix (HLH) proteins plays a fundamental role in the regulation of cellular proliferation and differentiation. The major mechanism by which Id proteins are thought to inhibit differentiation is through interaction with other HLH proteins and inhibition of their DNA-binding activity. Howe...

journal_title：Molecular and cellular biology

authors： Roberts EC,Deed RW,Inoue T,Norton JD,Sharrocks AD

更新日期：2001-01-01 00:00:00

abstract：:In mammals, the gene coding for apolipoprotein AI (apoAI), a protein of the plasma lipid transport system, is expressed only in the liver and the intestine. A series of plasmids containing various lengths of sequences flanking the 5' end of the human apoAI gene were constructed and assayed for transient expression aft...

journal_title：Molecular and cellular biology

authors： Sastry KN,Seedorf U,Karathanasis SK

更新日期：1988-02-01 00:00:00

abstract：:Alternative splicing of the locus AbetaH-J-J generates three functionally distinct proteins: an enzyme, AbetaH (aspartyl-beta-hydroxylase), a structural protein of the sarcoplasmic reticulum membrane (junctin), and an integral membrane calcium binding protein (junctate). Junctin and junctate are two important proteins...

journal_title：Molecular and cellular biology

authors： Feriotto G,Finotti A,Volpe P,Treves S,Ferrari S,Angelelli C,Zorzato F,Gambari R

更新日期：2005-04-01 00:00:00

abstract：:The E1B 19-kilodalton protein (19K protein) is a potent apoptosis inhibitor and the adenovirus homolog of Bcl-2 (E. White, Genes Dev. 10:1-15, 1996). To obtain a better understanding of the biochemical mechanism by which the E1B 19K protein regulates apoptosis, proteins that interact with 19K have been identified; one...

journal_title：Molecular and cellular biology

authors： Han J,Sabbatini P,White E

更新日期：1996-10-01 00:00:00

abstract：:Precise regulation of cellular proliferation, differentiation, and senescence results in the continuous renewal of the intestinal epithelium with maintenance of a highly ordered tissue architecture. Here we show that an intestine-specific homeobox gene, Cdx2, is a transcription factor that regulates both proliferation...

journal_title：Molecular and cellular biology

authors： Suh E,Traber PG

更新日期：1996-02-01 00:00:00

abstract：:Two cDNAs derived from Xenopus laevis calmodulin mRNA have been cloned. Both cDNAs contain the complete protein-coding region and various lengths of untranslated segments. The two cDNAs encode an identical protein but differ from each other by 5% nucleotide substitutions. The 5' and 3' untranslated regions, to the ext...

journal_title：Molecular and cellular biology

authors： Chien YH,Dawid IB

更新日期：1984-03-01 00:00:00

abstract：:In this report, we document an unusual mode of tissue-enriched gene expression that is primarily mediated by alternative and inefficient splicing. We have analyzed posttranscriptional regulation of the Drosophila erect wing gene, which provides a vital neuronal function and is essential for the formation of certain mu...

journal_title：Molecular and cellular biology

authors： Koushika SP,Soller M,DeSimone SM,Daub DM,White K

更新日期：1999-06-01 00:00:00

abstract：:IRE1-alpha is an integral membrane protein of the endoplasmic reticulum (ER) that is a key sensor in the cellular transcriptional response to stress in the ER. Upon induction of ER stress, IRE1-alpha is activated, resulting in the synthesis of the active form of the transcription factor XBP1 via IRE1-mediated splicing...

journal_title：Molecular and cellular biology

authors： Huang ZM,Tan T,Yoshida H,Mori K,Ma Y,Yen TS

更新日期：2005-09-01 00:00:00

abstract：:Two Saccharomyces cerevisiae genes isolated in a differential hybridization screening for DNA damage regulation (DDR genes) were also transcriptionally regulated by heat shock treatment. A 0.45-kilobase transcript homologous to the DDRA2 gene and a 1.25-kilobase transcript homologous to the DDR48 gene accumulated afte...

journal_title：Molecular and cellular biology

authors： McClanahan T,McEntee K

更新日期：1986-01-01 00:00:00

abstract：:Transcription initiation factor TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. To further understand the role of the 85-kDa TFIID subunit (p85), we have cloned the corresponding cDNA with a probe based on an amino acid sequence of t...

journal_title：Molecular and cellular biology

authors： Kokubo T,Gong DW,Yamashita S,Takada R,Roeder RG,Horikoshi M,Nakatani Y

更新日期：1993-12-01 00:00:00

abstract：:Placental development initially occurs in a low-oxygen (O2) or hypoxic environment. In this report we show that two hypoxia-inducible factors (HIFs), HIF1alpha and HIF2alpha, are essential for determining murine placental cell fates. HIF is a heterodimer composed of HIFalpha and HIFbeta (ARNT) subunits. Placentas from...

journal_title：Molecular and cellular biology

authors： Cowden Dahl KD,Fryer BH,Mack FA,Compernolle V,Maltepe E,Adelman DM,Carmeliet P,Simon MC

更新日期：2005-12-01 00:00:00

abstract：:Our analysis of rotund (rn) null mutations in Drosophila melanogaster revealed that deletion of the rn locus affects both spermatid and retinal differentiation. In the male reproductive system, the absence of RnRacGAP induced small testes, empty seminal vesicles, short testicular cysts, reduced amounts of interspermat...

journal_title：Molecular and cellular biology

authors： Bergeret E,Pignot-Paintrand I,Guichard A,Raymond K,Fauvarque MO,Cazemajor M,Griffin-Shea R

更新日期：2001-09-01 00:00:00

abstract：:The active beta-globin genes in chicken erythrocytes, like all active genes, reside in large chromatin domains which are preferentially sensitive to digestion by DNase I. We have recently proposed that the special structure of chromatin in active domains is maintained by torsional stress in the DNA (Villeponteau et al...

journal_title：Molecular and cellular biology

authors： Villeponteau B,Martinson HG

更新日期：1987-05-01 00:00:00

abstract：:It has been hypothesized that protein factors may protect CpG islands from methyltransferase during development and that demethylation may involve protein-DNA interactions at demethylated sites. However, direct evidence has been lacking. In this study, demethylation at the EBNA-1 binding sites of the Epstein-Barr viru...

journal_title：Molecular and cellular biology

authors： Hsieh CL

更新日期：1999-01-01 00:00:00

abstract：:The liver-enriched transcription factor C/EBP alpha has been implicated in the regulation of numerous liver-specific genes. It was previously reported that mice carrying a homozygous null mutation at the c/ebp alpha locus died as neonates due to the absence of hepatic glycogen and the resulting hypoglycemia. However, ...

journal_title：Molecular and cellular biology

authors： Lee YH,Sauer B,Johnson PF,Gonzalez FJ

更新日期：1997-10-01 00:00:00

abstract：:TSLC1/IGSF4, an immunoglobulin superfamily molecule, is predominantly expressed in the brain, lungs, and testes and plays important roles in epithelial cell adhesion, cancer invasion, and synapse formation. We generated Tslc1/Igsf4-deficient mice by disrupting exon 1 of the gene and found that Tslc1(-/-) mice were bor...

journal_title：Molecular and cellular biology

authors： Yamada D,Yoshida M,Williams YN,Fukami T,Kikuchi S,Masuda M,Maruyama T,Ohta T,Nakae D,Maekawa A,Kitamura T,Murakami Y

更新日期：2006-05-01 00:00:00

abstract：:The Ace2p and Swi5p zinc finger proteins have nearly identical DNA-binding domains, yet in vivo they activate transcription of different genes, CTS1 and HO. We now demonstrate that Ace2p and Swi5p recognize sites in the CTS1 and HO promoters with the same affinities, raising the question of how promoter specificity is...

journal_title：Molecular and cellular biology

authors： Dohrmann PR,Voth WP,Stillman DJ

更新日期：1996-04-01 00:00:00

abstract：:To examine the sequence complexity and differential expression of human alpha-tubulin genes, we constructed cDNA libraries from two unrelated tissue types (epidermis and fetal brain). The complete sequence of a positively hybridizing alpha-tubulin clone from each library is described. Each is shown to represent an abu...

journal_title：Molecular and cellular biology

authors： Cowan NJ,Dobner PR,Fuchs EV,Cleveland DW

更新日期：1983-10-01 00:00:00

abstract：:In mammals, molecular mechanisms and factors involved in the tight regulation of telomerase expression and activity are still largely undefined. In this study, we provide evidence for a role of estrogens and their receptors in the transcriptional regulation of hTERT, the catalytic subunit of human telomerase and, cons...

journal_title：Molecular and cellular biology

authors： Misiti S,Nanni S,Fontemaggi G,Cong YS,Wen J,Hirte HW,Piaggio G,Sacchi A,Pontecorvi A,Bacchetti S,Farsetti A

更新日期：2000-06-01 00:00:00

abstract：:We have reported that the papillomavirus E2 protein binds the nuclear factor AMF1 (also called G-protein pathway suppressor 2 or GPS2) and that their interaction is necessary for transcriptional activation by E2. It has also been shown that AMF1 can influence the activity of cellular transcription factors. These obser...

journal_title：Molecular and cellular biology

authors： Peng YC,Kuo F,Breiding DE,Wang YF,Mansur CP,Androphy EJ

更新日期：2001-09-01 00:00:00

abstract：:The murine int-1 proto-oncogene has been implicated in neural development and, when transcriptionally activated by mouse mammary tumor virus, contributes to the genesis of mammary tumors. To understand the function of the int-1 gene product in these processes, we have characterized the biochemical properties of int-1 ...

journal_title：Molecular and cellular biology

authors： Papkoff J,Schryver B

更新日期：1990-06-01 00:00:00