Abstract：
:Sensorineural hearing loss (SNHL) is one of the most common diseases, accounting for about 90% of all hearing loss. Leading causes of SNHL include advanced age, ototoxic medications, noise exposure, inherited and autoimmune disorders. Most of SNHL is irreversible and managed with hearing aids or cochlear implants. Although there is increased understanding of the molecular pathophysiology of SNHL, biologic treatment options are limited due to lack of noninvasive targeted delivery systems. Obstacles of targeted inner ear delivery include anatomic inaccessibility, biotherapeutic instability, and nonspecific delivery. Advances in nanotechnology may provide a solution to these barriers. Nanoparticles can stabilize and carry biomaterials across the round window membrane into the inner ear, and ligand bioconjugation onto nanoparticle surfaces allows for specific targeting. A newer technology, nanohydrogel, may offer noninvasive and sustained biotherapeutic delivery into specific inner ear cells. Nanohydrogel may be used for inner ear dialysis, a potential treatment for ototoxicity-induced SNHL.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Li L,Chao T,Brant J,O'Malley B Jr,Tsourkas A,Li Ddoi
10.1016/j.addr.2016.01.004subject
Has Abstractpub_date
2017-01-01 00:00:00pages
2-12eissn
0169-409Xissn
1872-8294pii
S0169-409X(16)30006-0journal_volume
108pub_type
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