Abstract:
:Hydrogels have been used primarily in the pharmaceutical field as carriers for delivery of various drugs, peptides and proteins. These systems have included stimuli-responsive gels that exhibit reversible swelling behavior and hence can show modulated release in response to external stimuli such as pH, temperature, ionic strength, electric field, or specific analyte concentration gradients. The focus of this article is to review molecular imprinting within hydrogels and discuss recent efforts on analyte-responsive intelligent gels, specifically suggesting the possibility of utilizing molecular imprinting strategies to impart analyte specificity and responsiveness within these systems. Molecular imprinting is an emerging field that produces precise chemical architecture that can bind analytes and differentiate between similar molecules with enantiomeric resolution. On the forefront of imprinting gel systems are intelligent, stimuli-sensitive imprinted gels that modify their swelling behavior and in turn modulate their analyte binding abilities. We discuss the challenges creating an imprinting effect in hydrogels and the possibilities of using molecularly imprinted mechanisms within controlled release gels.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Byrne ME,Park K,Peppas NAdoi
10.1016/s0169-409x(01)00246-0subject
Has Abstractpub_date
2002-01-17 00:00:00pages
149-61issue
1eissn
0169-409Xissn
1872-8294pii
S0169409X01002460journal_volume
54pub_type
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