Oxybutynin chloride for geriatric urinary dysfunction: a double-blind placebo-controlled study.

Abstract:

:Twenty-four incontinent elderly institutionalized subjects with detrusor instability participated in a double-blind placebo-controlled trial of oxybutynin chloride. Patients were randomly assigned to oral oxybutynin 5 mg or placebo twice daily. Administration continued for 8 days; a 6-day washout period was followed by the alternative treatment. Incontinence was recorded using a bedside electronic monitor. Four subjects withdrew because of side-effects before completing the trial. There were no clinically significant differences between the oxybutynin and placebo treatments. Both groups experienced side-effects, of which dry mouth was the commonest. Thus, oxybutynin does not appear to be more effective than placebo for the treatment of incontinence in the presence of detrusor instability in elderly institutionalized people.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Zorzitto ML,Holliday PJ,Jewett MA,Herschorn S,Fernie GR

doi

10.1093/ageing/18.3.195

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

195-200

issue

3

eissn

0002-0729

issn

1468-2834

journal_volume

18

pub_type

临床试验,杂志文章,随机对照试验,评审
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