Missed diagnosis of pulmonary embolism with age-adjusted d-dimer cut-off value.

Abstract:

:Pulmonary embolism (PE) is a potentially severe diagnosis with high short-term mortality. Recently, age-adjusted cut-off values (age × 10 μg/l) of D-dimer were introduced to improve the diagnostic workup in older patients. In clinical practice, PE is considered 'ruled out' in patients with a non-high clinical probability and a normal D-dimer. However, all diagnostic tests have a small false-negative rate. This small probability of misdiagnosis might be easily overlooked by clinicians when using simplified dichotomized flow charts. This case illustrates a normal D-dimer (age-adjusted) but with a PE. We recommend clinicians using the D-dimer test-either conventional or age-adjusted in a rule-out strategy to be aware of the-albeit small probability of a false-negative result.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Stein CE,Keijsers CJ,Bootsma JE,Schouten HJ

doi

10.1093/ageing/afw132

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

910-911

issue

6

eissn

0002-0729

issn

1468-2834

pii

afw132

journal_volume

45

pub_type

杂志文章
  • Evidence of cellular zinc depletion in hospitalized but not in healthy elderly subjects.

    abstract::Cellular immune function declines with age and is implicated in the increased incidence of cancer, and morbidity and mortality associated with infections in elderly people. Elderly people are at risk of nutritional depletion, including of zinc, and zinc is known to influence immunity. The present study assessed zinc s...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/20.5.345

    authors: Goode HF,Penn ND,Kelleher J,Walker BE

    更新日期:1991-09-01 00:00:00

  • Use of antipsychotics among nonagenarian residents in long-term institutional care in Finland.

    abstract:BACKGROUND:There is a paucity of information about the use of antipsychotic medication in long-term care, especially among the oldest-old residents. OBJECTIVE:To analyse the factors associated with the use of antipsychotic medication among nonagenarian residents in long-term institutional care. DESIGN:A retrospective...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afl065

    authors: Alanen HM,Finne-Soveri H,Noro A,Leinonen E

    更新日期:2006-09-01 00:00:00

  • A double-blind comparison of quinine sulphate and placebo in muscle cramps.

    abstract::Muscle cramps are painful and common in elderly patients but have largely escaped medical investigation. Quinine sulphate is usually the sole drug prescribed, even though firm evidence for its efficacy is not available. The results of the present double-blind cross-over study show that quinine was significantly superi...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/12.2.155

    authors: Jones K,Castleden CM

    更新日期:1983-05-01 00:00:00

  • Nutritional differences in patients with proximal femoral fractures.

    abstract:BACKGROUND:The reason why elderly human hips tend to break in one of two anatomical regions is uncertain. Nutritional factors may affect the site of fracture. OBJECTIVE:To assess possible nutritional differences in patients with proximal femoral fractures. DESIGN:Prospective observational cohort study. SETTING:Unive...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/28.5.458

    authors: Maffulli N,Dougall TW,Brown MT,Golden MH

    更新日期:1999-09-01 00:00:00

  • Doege-Potter syndrome: hypoglycaemic coma in a 90-year old due to a solitary fibrous tumour.

    abstract::Solitary fibrous tumour of the pleura (SFTP) is a rare primary tumour of the pleura associated with 4% of cases with a paraneoplastic hypoglycaemia, termed Doege-Potter syndrome (DPS). We report a case of DPS presenting with severe coma in a 90-year-old woman. The cause was a malignant SFTP treated with surgical resec...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw221

    authors: Avramenko A,Lahjibi-Paulet H,Gibault L,Roussel A,Grand B,Le Pimpec-Barthes F

    更新日期:2017-05-01 00:00:00

  • Increased levels of soluble Receptor for Advanced Glycation End-products (RAGE) are associated with a higher risk of mortality in frail older adults.

    abstract:OBJECTIVE:to evaluate the relationship between serum levels of the soluble Receptor for Advanced Glycation End-products (sRAGE) and mortality in frail and non-frail older adults. METHODS:we studied 691 subjects (141 frail and 550 non-frail) with a median age of 75 years from two population-based cohorts, the Toledo St...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afz073

    authors: Butcher L,Carnicero JA,Gomez Cabrero D,Dartigues JF,Pérès K,Garcia-Garcia FJ,Rodriguez-Mañas L,Erusalimsky JD,FRAILOMIC Consortium.

    更新日期:2019-09-01 00:00:00

  • Senile parkinsonism, a study of current treatment.

    abstract::In a survey of all 2069 in-patients at 14 geriatric centres, 249 patients were found to have received drugs for the treatment of parkinsonism. There was a wide variation in point prevalence which varied from 4.6% to 22.6% between centres. Levodopa, usually in combination with a decarboxylase inhibitor, was the most fr...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/10.2.81

    authors: White NJ,Barnes TR

    更新日期:1981-05-01 00:00:00

  • Variability of response to thyroid-releasing hormone in normal elderly.

    abstract::The present study was undertaken to define the hormonal response to thyroid-releasing hormone (TRH) further in a large, healthy, ambulatory elderly group. Seventy-seven subjects over 60 years old, 30 males (MA) and 47 females (FA), and control subjects, 22 males (MC) and 42 females (FC) were studied. No difference in ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/16.6.345

    authors: Kaiser FE

    更新日期:1987-11-01 00:00:00

  • Delay in diagnosis of colorectal cancer in elderly patients.

    abstract::The medical histories of 178 colorectal cancer patients were studied retrospectively from hospital records. The average age at the time of diagnosis was 71 years. Visible loss of blood or anaemia were the commonest features. The mean time from first symptom to first medical consultation was 82.8 days. Men under 65 yea...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/22.4.260

    authors: Kemppainen M,Räihä I,Rajala T,Sourander L

    更新日期:1993-07-01 00:00:00

  • Confirming long-stay status.

    abstract::This paper discusses an assessment procedure for the formal identification of patients requiring long-stay geriatric care. It was introduced immediately prior to the reorganization of geriatric in-patient care at St Pancras Hospital which saw the abolition of mixed wards of acute, rehabilitation, and long-stay patient...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/16.1.13

    authors: Golding R,Lugon M,Hodkinson HM

    更新日期:1987-01-01 00:00:00

  • Quantification of proteinuria: a re-evaluation of the protein/creatinine ratio for elderly subjects.

    abstract::The difficulties of 24-hour urine collection are well recognized, especially for elderly people for whom a means of estimating protein excretion from a single casual unit sample would be preferable. We compared measurement of total urinary protein estimated by the protein/creatinine ratio with 24-h urine collection an...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/22.6.443

    authors: Mitchell SC,Sheldon TA,Shaw AB

    更新日期:1993-11-01 00:00:00

  • Recovery in instrumental activities of daily living (IADLs): findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

    abstract:OBJECTIVE:to provide evidence for predictors of recovery in instrumental activities of daily living (IADLs) among disabled older people living in the community. DESIGN:MRC CFAS recruited a sample of 13,004 individuals aged 65 years and above from five communities in the UK. Participants underwent a baseline interview ...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afp128

    authors: Seidel D,Jagger C,Brayne C,Matthews FE,Cfas M

    更新日期:2009-11-01 00:00:00

  • Intravenous cannulation alters the specificity of head-up tilt testing for vasovagal syncope in elderly patients.

    abstract::Prolonged head-up tilt is increasingly used as a diagnostic test for vasovagal syncope. Its sensitivity is reported to increase with the concurrent administration of intravenous isoprenaline. False-positive responses are common in young controls particularly following intravascular instrumentation. We studied the infl...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/23.4.317

    authors: McIntosh SJ,Lawson J,Kenny RA

    更新日期:1994-07-01 00:00:00

  • The natural history of delirium in older hospitalized patients: a syndrome of heterogeneity.

    abstract:OBJECTIVES:To determine the presentation, course and duration of delirium in hospitalized older people. DESIGN:Observational cohort study. SETTING:Inpatient surgical and medical wards at a university hospital. PARTICIPANTS:432 people over the age of 65. MEASUREMENTS:All participants were screened daily for confusio...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/26.3.169

    authors: Rudberg MA,Pompei P,Foreman MD,Ross RE,Cassel CK

    更新日期:1997-05-01 00:00:00

  • Identifying a sample of elderly people by a postal screen.

    abstract::This paper describes how a sample of elderly people were identified from the electoral register using an initial postal screen, and reports a technique that was used to increase the response to the screen. ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/16.2.119

    authors: Cartwright A,Smith C

    更新日期:1987-03-01 00:00:00

  • ACE inhibitors, statins and thiazides: no association with change in grip strength among community dwelling older men and women from the Hertfordshire Cohort Study.

    abstract:BACKGROUND:vascular disease has been postulated to contribute to muscle dysfunction in old age. Previous studies examining the effects of cardiovascular drugs on muscle function have shown conflicting results. We therefore examined the association of angiotensin converting enzyme (ACE) inhibitor, thiazide and statin us...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afu008

    authors: Witham MD,Syddall HE,Dennison E,Cooper C,McMurdo ME,Sayer AA

    更新日期:2014-09-01 00:00:00

  • Low-molecular-weight heparin-associated fat necrosis of the breast.

    abstract::Fat necrosis of the breast is a well-recognised complication of unfractionated heparin. The following is a case of fat necrosis due to low-molecular-weight heparin in a 91-year-old woman admitted to hospital with unstable angina. ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afi032

    authors: Das AK

    更新日期:2005-03-01 00:00:00

  • Sports injuries in elderly athletes: a three-year prospective, controlled study.

    abstract::A 3-year prospective, controlled study of sports injuries in elderly athletes (over 60 years of age) treated at an outpatient sports clinic was carried out in order to determine the number, profile, and specific features of these injuries compared with those of young athletes (between 21 and 25 years). During the stud...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/18.4.263

    authors: Kannus P,Niittymäki S,Järvinen M,Lehto M

    更新日期:1989-07-01 00:00:00

  • High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old.

    abstract:OBJECTIVE:to explore the relationship between blood lipids/lipoproteins and cognitive function in the Chinese oldest-old. DESIGN:multivariate statistical analysis using cross-sectional data. SETTING:community-based setting in longevity areas in China. SUBJECTS:eight hundred and thirty-six subjects aged 80 and older ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs033

    authors: Yin ZX,Shi XM,Kraus VB,Fitzgerald SM,Qian HZ,Xu JW,Zhai Y,Sereny MD,Zeng Y

    更新日期:2012-09-01 00:00:00

  • Effects of a physiotherapist-led stroke training programme for nurses.

    abstract:AIM:to assess the effects of a physiotherapist-led stroke training programme for nurses working in a rehabilitation ward on clinical practice and patient outcome. METHOD:before and after group comparison with outcome assessment by observational and quantitative methods. Non-participant observation before and after the...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/28.6.567

    authors: Forster A,Dowswell G,Young J,Sheard J,Wright P,Bagley P

    更新日期:1999-10-01 00:00:00

  • Peritonitis in geriatric inpatients.

    abstract::Of 212 cases of peritonitis found in a retrospective study of geriatric inpatients, the most common causes were mesenteric infarction, malignancy, intestinal obstruction, perforated peptic ulcer, cholecystitis, diverticulitis and perforation of the urinary bladder. The diagnostic accuracy was 47%. Abdominal pain had b...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/20.2.90

    authors: Wroblewski M,Mikulowski P

    更新日期:1991-03-01 00:00:00

  • Effect of the COVID-19 Lockdown on Disease Recognition and Utilization of Healthcare Services in the Older Population in German: A Cross-sectional Study.

    abstract:BACKGROUND:There is little evidence about the utilization of healthcare services and disease recognition in the older population, which was urged to self-isolate during the COVID-19 lockdowns. OBJECTIVES:We aimed to describe the utilization of physician consultations, specialist referrals, hospital admissions, and the...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa260

    authors: Michalowsky B,Hoffmann W,Bohlken J,Kostev K

    更新日期:2020-11-17 00:00:00

  • Interleukin-1 production by human monocytes in ageing and disease.

    abstract::Interleukin-1 mediates the febrile response which is often said to be reduced in the elderly. Interleukin-1 production by monocytes cultured in vitro and stimulated with bacterial lipopolysaccharide was measured. Three groups of subjects were studied; 40 normal young, 33 well elderly and 40 elderly with a history of r...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/18.1.43

    authors: Rudd AG,Banerjee DK

    更新日期:1989-01-01 00:00:00

  • Myocardial contractility in aged rats.

    abstract::The elastic and mechanical behaviour of isolated papillar muscle was studied in aged and in young rats. The spontaneous fall in tension (stress relaxation phenomenon) and the duration of the active state of the contractile element during the isometric and isotonic contraction were greater in aged than in young rats. T...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/5.2.71

    authors: Minelli R,Reggiani C,De Nicola P

    更新日期:1976-05-01 00:00:00

  • A dose response relationship between accelerometer assessed daily steps and depressive symptoms in older adults: a two-year cohort study.

    abstract:OBJECTIVES:this study investigated the prospective associations of accelerometer assessed daily steps with subsequent depressive symptoms in older adults. METHODS:a 2-year prospective study was performed in the community. A total of 285 older adults ≥65 years (mean age = 74.5) attended the baseline assessment in 2012....

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa162

    authors: Hsueh MC,Stubbs B,Lai YJ,Sun CK,Chen LJ,Ku PW

    更新日期:2020-09-25 00:00:00

  • Patterns of mortality in homes for the elderly.

    abstract::High rates of mortality are an abiding feature of homes for the elderly. Almost a fifth (19.2%) of a cohort of 6947 residents died in the 12 months following initial assessment. Survival rates vary widely, however, for different groups within the residential population. Using data from a longitudinal study of 175 home...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/12.3.240

    authors: Booth T,Phillips D,Barritt A,Berry S,Martin DN,Melotte C

    更新日期:1983-08-01 00:00:00

  • Plasma paroxonase activity in old age.

    abstract::Genetic factors are known to be of importance in determining the rate of biotransformation of foreign compounds in the liver. Adverse reactions to drugs are increased and pharmacokinetic parameters altered with age. In the present study, the effect of age on plasma paroxonase activity is studied. Paroxonase is a hepat...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/6.2.89

    authors: Playfer JR,Powell C,Evans DA

    更新日期:1977-05-01 00:00:00

  • Association of age at diagnosis and Crohn's disease phenotype.

    abstract:BACKGROUND:fifteen percent of patients with Crohn's disease (CD) are elderly; they are less likely to have complications and more likely to have colonic disease. OBJECTIVE:to compare disease behaviour in patients with CD based on age at diagnosis. DESIGN:cross-sectional study. SETTING:tertiary referral centre. SUBJ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs107

    authors: Quezada SM,Steinberger EK,Cross RK

    更新日期:2013-01-01 00:00:00

  • Impairments in hearing and vision impact on mortality in older people: the AGES-Reykjavik Study.

    abstract:OBJECTIVE:to examine the relationships between impairments in hearing and vision and mortality from all-causes and cardiovascular disease (CVD) among older people. DESIGN:population-based cohort study. PARTICIPANTS:the study population included 4,926 Icelandic individuals, aged ≥67 years, 43.4% male, who completed vi...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/aft122

    authors: Fisher D,Li CM,Chiu MS,Themann CL,Petersen H,Jónasson F,Jónsson PV,Sverrisdottir JE,Garcia M,Harris TB,Launer LJ,Eiriksdottir G,Gudnason V,Hoffman HJ,Cotch MF

    更新日期:2014-01-01 00:00:00

  • Effects of functional tasks exercise on older adults with cognitive impairment at risk of Alzheimer's disease: a randomised controlled trial.

    abstract:OBJECTIVE:the aim of this study was to compare the effects of a functional tasks exercise programme to a cognitive training programme in older adults with mild cognitive impairment. DESIGN:a single-blind randomised control trial with the intervention group compared with an active control group. SETTING:out-patient cl...

    journal_title:Age and ageing

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ageing/afu055

    authors: Law LL,Barnett F,Yau MK,Gray MA

    更新日期:2014-11-01 00:00:00