CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2.

abstract：:Both chemokine receptors (CXCRs) 7 and 4 can facilitate immune cell migration and mediate a vast array of physiological and pathological events. Herein we report, in both human and animal studies, that these two CXCRs can form heterodimers in vivo and promote colorectal tumorigenesis through histone demethylation. Com...

journal_title：Oncogene

authors： Song ZY,Wang F,Cui SX,Gao ZH,Qu XJ

更新日期：2019-02-01 00:00:00

abstract：:A series of primary human breast tumors was analysed by immunoblotting with anti-neu antibodies. Overproduction of the neu protein-tyrosine kinase, p185neu, was observed in 23 of 56 malignant tumor samples. 29 of these tumors were also immunoblotted with antiphosphotyrosine antibodies. A single prominent phosphotyrosi...

journal_title：Oncogene

authors： Wildenhain Y,Pawson T,Blackstein ME,Andrulis IL

更新日期：1990-06-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is an inducible enzyme that contributes to the generation of chronic inflammation in response to chemical carcinogens and environmental stresses, including ultraviolet B (UVB) irradiation. Although post-translational histone modifications are believed to have an important role in modulating tr...

journal_title：Oncogene

authors： Keum YS,Kim HG,Bode AM,Surh YJ,Dong Z

更新日期：2013-01-24 00:00:00

abstract：:Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population. This phenomenon, termed the 'bystander response', has been shown to occur both in vi...

journal_title：Oncogene

authors： Azzam EI,de Toledo SM,Little JB

更新日期：2003-10-13 00:00:00

abstract：:A distinctive subset of renal carcinomas is associated with Xp11. 2 translocations and resulting TFE3 gene fusions (PRCC-TFE3, PSF-TFE3, NONO-TFE3, ASPL-TFE3), encoding related aberrant transcription factors. We report the cloning of a novel clathrin heavy-chain gene (CLTC)-TFE3 gene fusion resulting from a t(X;17)(p1...

journal_title：Oncogene

authors： Argani P,Lui MY,Couturier J,Bouvier R,Fournet JC,Ladanyi M

更新日期：2003-08-14 00:00:00

abstract：:We have recently described the N-terminal RAS association domain family of genes, RASSF7-10. Previously, we cloned the N-terminal RASSF10 gene and demonstrated frequent methylation of the associated 5'-CpG island in acute lymphoblastic leukemia. To characterize RASSF10 gene expression, we demonstrate that in developin...

journal_title：Oncogene

authors： Hill VK,Underhill-Day N,Krex D,Robel K,Sangan CB,Summersgill HR,Morris M,Gentle D,Chalmers AD,Maher ER,Latif F

更新日期：2011-02-24 00:00:00

abstract：:Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) has been suggested to be involved in tumor metastasis. However, the molecular mechanism of LMP1-induced metastasis is largely unknown. In this study, we investigated the effect of LMP1 on the expression of RECK, a metastasis suppressor gene, in an EBV-negative ...

journal_title：Oncogene

authors： Liu LT,Peng JP,Chang HC,Hung WC

更新日期：2003-11-13 00:00:00

abstract：:FHIT (Fragile Histidine Triad), a putative tumor suppressor gene, was cloned from fetal brain and colon cDNA libraries. Portions of this gene are deleted in esophageal, colon, lung and breast tumors, but this gene has not been found altered in sporadic renal cell carcinomas. We report here an alternatively spliced for...

journal_title：Oncogene

authors： Luan X,Shi G,Zohouri M,Paradee W,Smith DI,Decker HJ,Cannizzaro LA

更新日期：1997-07-03 00:00:00

abstract：:Progesterone receptor (PR) is usually co-localized with estrogen receptor (ER) in normal mammary cells. It is not known whether ER/PR-negative human breast cancer arises from an ER/PR-negative cell or from an ER/PR-positive cell that later lost ER/PR. Using intraductal injection of a lentivirus to deliver both an onco...

journal_title：Oncogene

authors： Dong J,Zhao W,Shi A,Toneff M,Lydon J,So D,Li Y

更新日期：2016-08-04 00:00:00

abstract：:Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in...

journal_title：Oncogene

authors： Fuchs SY,Spiegelman VS,Kumar KG

更新日期：2004-03-15 00:00:00

abstract：:One of the key events in tumor initiation in mouse skin is mutational activation of the H-ras gene. Papillomas induced by the most carcinogenic environmental polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DB[a,l]P), in SENCAR mouse skin contain a specific H-ras codon 61 (CAA-->CTA) mutation. We describe he...

journal_title：Oncogene

authors： Chakravarti D,Mailander P,Franzen J,Higginbotham S,Cavalieri EL,Rogan EG

更新日期：1998-06-18 00:00:00

abstract：:Protein kinases are known to undergo phosphorylation to regulate their activity. To determine whether the protein kinase activity of p37v-mos was similarly regulated, we investigated the influence of two well known protein kinases, namely protein kinase C and protein kinase A, on the activity of p37v-mos in vivo. NIH3...

journal_title：Oncogene

authors： al-Bagdadi F,Singh B,Arlinghaus RB

更新日期：1990-08-01 00:00:00

abstract：:The etiology of cancers appears to be complex and multifactorial. Peyton Rous and others demonstrated the process of co-carcinogenesis by exposing rabbits to a virus and tars. Epidemiologists have proposed virus-chemical interactions to cause several cancers. For example, one might propose that the etiology of cervica...

journal_title：Oncogene

authors： Haverkos HW

更新日期：2004-08-23 00:00:00

abstract：:High-throughput, human cell-based applications of RNA-mediated interference (RNAi) have emerged in recent years as perhaps the most powerful of a 'second wave' of functional genomics technologies. The available reagents and methodologies for RNAi screening studies now enable a wide range of different scopes and scales...

journal_title：Oncogene

authors： Sachse C,Echeverri CJ

更新日期：2004-11-01 00:00:00

abstract：:Myxoid and round-cell liposarcomas share the translocation t(12;16)(q13;p11) creating the TLS-CHOP fusion gene as a common genetic alteration. We previously reported several unique characteristics of genomic sequences around the breakpoints in the TLS and CHOP loci, and among them was the presence of consensus recogni...

journal_title：Oncogene

authors： Hosaka T,Kanoe H,Nakayama T,Murakami H,Yamamoto H,Nakamata T,Tsuboyama T,Oka M,Kasai M,Sasaki MS,Nakamura T,Toguchida J

更新日期：2000-11-23 00:00:00

abstract：:Signal transducers and activators of transcription (Stats) are known to transduce signals from the cell surface to the nucleus in cytokine receptor signaling. We examined the capacity of platelet-derived growth factor (PDGF) receptor to interact with and activate Stat molecules. Activation of the PDGF beta-receptor le...

journal_title：Oncogene

authors： Valgeirsdóttir S,Paukku K,Silvennoinen O,Heldin CH,Claesson-Welsh L

更新日期：1998-01-29 00:00:00

abstract：:Mdm2 is the major negative regulator of p53 tumor-suppressor activity. This oncoprotein is overexpressed in many human tumors that retain the wild-type p53 allele. As such, targeted inhibition of Mdm2 is being considered as a therapeutic anticancer strategy. The N-terminal hydrophobic pocket of Mdm2 binds to p53 and t...

journal_title：Oncogene

authors： Wade M,Li YC,Matani AS,Braun SM,Milanesi F,Rodewald LW,Wahl GM

更新日期：2012-11-08 00:00:00

abstract：:Making decisions between self-renewal and differentiation is a central ability of stem cells. Elucidation of molecular networks governing this decision is therefore of prime importance. A model of choice to explore this question is represented by chicken erythroid progenitors, in which self-renewal versus differentiat...

journal_title：Oncogene

authors： Dazy S,Damiola F,Parisey N,Beug H,Gandrillon O

更新日期：2003-12-18 00:00:00

abstract：:Constitutive activation of signal transducer and activator of transcription (STAT) proteins has been detected in a wide variety of human primary tumor specimens and tumor cell lines including blood malignancies, head and neck cancer, and breast cancer. We have previously demonstrated a high frequency of Stat3 DNA-bind...

journal_title：Oncogene

authors： Garcia R,Bowman TL,Niu G,Yu H,Minton S,Muro-Cacho CA,Cox CE,Falcone R,Fairclough R,Parsons S,Laudano A,Gazit A,Levitzki A,Kraker A,Jove R

更新日期：2001-05-03 00:00:00

abstract：:The p53 tumor suppressor protein and the Akt/PKB kinase play important roles in the transduction of pro-apoptotic and anti-apoptotic signals, respectively. We provide evidence that conflicting signals transduced by Akt and p53 are integrated via negative feedback between the two pathways. On the one hand, the combinat...

journal_title：Oncogene

authors： Gottlieb TM,Leal JF,Seger R,Taya Y,Oren M

更新日期：2002-02-14 00:00:00

abstract：:Minichromosome maintenance (MCM) proteins 2-7 are important in DNA replication licensing. Functional roles beyond licensing are speculated. In addition, significances in medulloblastoma (MB) remain unclear. In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinica...

journal_title：Oncogene

authors： Lau KM,Chan QK,Pang JC,Li KK,Yeung WW,Chung NY,Lui PC,Tam YS,Li HM,Zhou L,Wang Y,Mao Y,Ng HK

更新日期：2010-10-07 00:00:00

abstract：:Chromatin remodeling proteins regulate multiple aspects of cell homeostasis, making them ideal candidates for misregulation in transformed cells. Here, we explore Sin3A, a member of the Sin3 family of proteins linked to tumorigenesis that are thought to regulate gene expression through their role as histone deacetylas...

journal_title：Oncogene

authors： Das TK,Sangodkar J,Negre N,Narla G,Cagan RL

更新日期：2013-06-27 00:00:00

abstract：:Signal transduction and activator of transcription 3(STAT3) signaling is constitutively activated in various tumors, and is involved in cell survival and proliferation during oncogenesis. There are few reports, however, on the role of STAT3 signaling in gastric cancer. The aim of the present study was to clarify the r...

journal_title：Oncogene

authors： Kanda N,Seno H,Konda Y,Marusawa H,Kanai M,Nakajima T,Kawashima T,Nanakin A,Sawabu T,Uenoyama Y,Sekikawa A,Kawada M,Suzuki K,Kayahara T,Fukui H,Sawada M,Chiba T

更新日期：2004-06-17 00:00:00

abstract：:The human cellular homolog of v-rel, the transforming gene of reticuloendotheliosis virus, strain T, was previously localized to 2 cent-2p13 by a combination of somatic cell hybrid and in situ hybridization analyses. In this study, we use translocation chromosome analysis to refine c-rel's genetic assignment to 2p12-2...

journal_title：Oncogene

authors： Brownell E,Fell HP,Tucker PW,Geurts van Kessel AH,Hagemeijer A,Rice NR

更新日期：1988-05-01 00:00:00

abstract：:A 1.26 kb murine cDNA having 31% homology with human ras and 55% homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily. Northern blot analysis indicates that the expression of the murine gene is restricted to the cells of hemopoiet...

journal_title：Oncogene

authors： Shirsat NV,Pignolo RJ,Kreider BL,Rovera G

更新日期：1990-05-01 00:00:00

abstract：:The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous cell carcinoma cell lines following irradiation. Isogenic p53-null radioresistant cancer cells established through cumulative irradi...

journal_title：Oncogene

authors： Chang HW,Kim MR,Lee HJ,Lee HM,Kim GC,Lee YS,Nam HY,Lee M,Jang HJ,Lee KE,Lee JC,Byun Y,Kim SW,Kim SY

更新日期：2019-05-01 00:00:00

abstract：:Biomarkers that predict disease progression might assist the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. Here, we investigated the role of collagen type XI alpha 1 (COL11A1) in cell invasiveness and tumor formation and the prognostic impact of COL11A1 expression in ovar...

journal_title：Oncogene

authors： Wu YH,Chang TH,Huang YF,Huang HD,Chou CY

更新日期：2014-06-26 00:00:00

abstract：:Defects in a developmental signaling pathway involving the mammalian homologue of the Drosophila segment polarity gene, patched are associated with human tumors such as basal cell carcinoma, medulloblastoma and squamous cell carcinoma. Loss of heterozygosity (LOH) in some of these tumor cells suggests that patched fun...

journal_title：Oncogene

authors： Koike C,Mizutani T,Ito T,Shimizu Y,Yamamichi N,Kameda T,Michimukai E,Kitamura N,Okamoto T,Iba H

更新日期：2002-04-18 00:00:00

abstract：:Germ-line alterations in BRCA1 are associated with an increased susceptibility to breast and ovarian cancer. BRCA1 is a 220-kDa protein that contains a tandem of two BRCA1 C-Terminal (BRCT) domains. Among missense and nonsense BRCA1 mutations responsible for family breast cancer, some are located into the BRCT tandem ...

journal_title：Oncogene

authors： Magnard C,Bachelier R,Vincent A,Jaquinod M,Kieffer S,Lenoir GM,Venezia ND

更新日期：2002-10-03 00:00:00

abstract：:Procollagen lysyl hydroxylase 1 (PLOD1) is highly expressed in malignant tumors such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer. Bioinformatics analysis revealed that PLOD1 is associated with the progression of GBM, particularly the most malignant mesenchymal subtype (MES). Moreover, ...

journal_title：Oncogene

authors： Wang Z,Shi Y,Ying C,Jiang Y,Hu J

更新日期：2021-01-08 00:00:00