Influence of female sex on hepatitis C virus infection progression and treatment outcomes.

Abstract:

BACKGROUND:The influence of sex on hepatitis C virus (HCV)-related outcomes is often neglected. The effects of sex on liver fibrosis progression and the effect of socioeconomic status on management are unclear. PATIENTS AND METHODS:Data were evaluated from patients followed at The Ottawa Hospital and Regional Viral Hepatitis Program. RESULTS:Of 1978 chronic HCV-infected patients, 630 (32%) were women. Women had lower liver enzyme levels, HCV RNA levels, and weight compared with men. Women were more likely to be non-genotype-1 infected, Black or Asian, and immigrants from Africa and Asia (all P<0.01). Under 50 years of age, women on average had lower fibrosis scores than men. Beyond the age of 50 years, the mean fibrosis scores were similar, suggesting a 'catch-up' phase. Women were less likely to have initiated interferon-based HCV antiviral therapy (35.3 vs. 43.3%, P=0.01). Crude sustained virological responses were higher in women (65.3 vs. 56.3%, P=0.03), but were similar to men as determined by multivariable analysis (odds ratio: 0.92, 95% confidence interval: 0.58-1.46). Women of low socioeconomic status were more likely to be HIV coinfected and had higher rates of fibrosis progression. Women living in low-income neighborhoods were less likely to achieve sustained virological response (odds ratio: 0.50, 95% confidence interval: 0.34-0.75, P=0.01) compared with women in higher income regions. CONCLUSION:Sex differences have been identified as a potential barrier to overcome when managing viral infections. Our analysis suggests that sex influences fibrosis progression, likelihood of initiating HCV antiviral therapy, and treatment outcomes.

authors

Corsi DJ,Karges W,Thavorn K,Crawley AM,Cooper CL

doi

10.1097/MEG.0000000000000567

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

405-11

issue

4

eissn

0954-691X

issn

1473-5687

journal_volume

28

pub_type

杂志文章
  • Sandostatin causing reversible thrombocytopenia.

    abstract::Esophageal variceal bleeding can be serious or life threatening. Drug-induced thrombocytopenia can further complicate such bleeding episodes. Thrombocytopenia because of sandostatin has been reported in the literature only once previously. We describe a case of sandostatin-induced reversible thrombocytopenia with a po...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328312180a

    authors: Chisholm S,Gummadi B,Vega KJ,House J

    更新日期:2009-04-01 00:00:00

  • Comparative study of spironolactone and eplerenone in management of ascites in patients of cirrhosis of liver.

    abstract:INTRODUCTION:The present study was conducted to compare the efficacy and side effects of Spironolactone and Eplerenone in management of ascites due to liver cirrhosis. MATERIALS AND METHODS:105 patients of ascites with liver cirrhosis were randomized into three groups of 35 patients each. Group I was given Spironolact...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001678

    authors: Sehgal R,Singh H,Singh IP

    更新日期:2020-04-01 00:00:00

  • Viridans group streptococci: an underestimated cause of spontaneous bacterial peritonitis in cirrhotic patients with ascites.

    abstract:OBJECTIVES:The objective of the study was to examine the characteristics of spontaneous bacterial peritonitis (SBP) caused by streptococci, in particular viridans group streptococci (VGS), and to investigate a potential association between the long-term administration of norfloxacin and high-level resistance to fluoroq...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200509000-00008

    authors: Bert F,Noussair L,Lambert-Zechovsky N,Valla D

    更新日期:2005-09-01 00:00:00

  • Key points from the revised Maastricht Consensus Report: the impact on general practice.

    abstract::The Maastricht 2 Consensus Report features evidence-based recommendations for the management of Helicobacter pylori infection. Strongly recommended indications for H. pylori eradication include duodenal and gastric ulcer, mucosa-associated lymphoid tissue lymphoma, atrophic gastritis, post gastric cancer resection, fi...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Bazzoli F

    更新日期:2001-08-01 00:00:00

  • Inappropriate use of the faecal occult blood test in a university hospital in the Netherlands.

    abstract:OBJECTIVES:Although all international guidelines state that there is no indication to perform a faecal occult blood test (FOBT) in symptomatic patients, we believe the test is frequently used as a diagnostic test. The objective of this study was to investigate whether the current guidelines for FOBT use are being follo...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328313bbd3

    authors: van Rijn AF,Stroobants AK,Deutekom M,Lauppe C,Sturk A,Bossuyt PM,Fockens P,Dekker E

    更新日期:2012-11-01 00:00:00

  • Chronic hepatitis C: treat or wait? A prospective study on reasons for treatment or nontreatment in the era of first-generation protease inhibitors.

    abstract:BACKGROUND AND AIMS:In many countries, current treatment for patients with chronic hepatitis C involves a combination of peginterferon and ribavirin, associated with a protease inhibitor for hepatitis C virus genotype 1. More recent and efficient less toxic antiviral treatments are now available for some patients. Thus...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0000000000000506

    authors: Feillant M,Jézéquel C,Lison H,Delluc A,Tanné F,Le Gruyer A,Ben Ali Z,Renard I,Latournerie M,Deugnier Y,Garioud A,Cadranel JF,Guyader D,Robaszkiewicz M,Nousbaum JB

    更新日期:2016-02-01 00:00:00

  • Detection of nodules in liver cirrhosis: spiral computed tomography or magnetic resonance imaging? A prospective study of 88 nodules in 34 patients.

    abstract::Detection and characterization of all focal lesions in the liver are critical for screening patients with chronic liver disease. The aim of this prospective study was to investigate the accuracy of magnetic resonance imaging (MRI) and spiral computed tomography for the diagnosis of hepatic nodules in cirrhotic patient...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200202000-00010

    authors: de Lédinghen V,Laharie D,Lecesne R,Le Bail B,Winnock M,Bernard PH,Saric J,Couzigou P,Balabaud C,Bioulac-Sage P,Drouillard J

    更新日期:2002-02-01 00:00:00

  • Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared.

    abstract:OBJECTIVE:To determine whether the sugar absorption test (SAT) during follow-up of patients with coeliac disease on a gluten-free diet (GFD) correlates with improvement of the villous architecture of the small intestine. METHODS:The SAT was performed in coeliacs at diagnosis and during follow-up with GFD. For the SAT,...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199603000-00006

    authors: Uil JJ,van Elburg RM,van Overbeek FM,Meyer JW,Mulder CJ,Heymans HS

    更新日期:1996-03-01 00:00:00

  • Dietary habits as risk factors for inflammatory bowel disease.

    abstract:OBJECTIVE:To examine the influence of dietary factors in Italian patients with ulcerative colitis and Crohn's disease. DESIGN:We studied dietary habits immediately prior to the onset of disease in 104 patients enrolled in a prospective, epidemiological study of the incidence of inflammatory bowel disease in Italy. ME...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Tragnone A,Valpiani D,Miglio F,Elmi G,Bazzocchi G,Pipitone E,Lanfranchi GA

    更新日期:1995-01-01 00:00:00

  • Risk factors for symptomatic stone recurrence after transpapillary laser lithotripsy for difficult bile duct stones using a laser with a stone recognition system.

    abstract:BACKGROUND:Laser-induced shock-wave lithotripsy (LISL) is successfully used for the treatment of difficult bile duct stones. The aim of this study was to assess the long-term risk for a symptomatic bile duct stone recurrence after LISL and to detect risk factors predicting recurrence. METHODS:Between 1993 and 2001, 80...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200605000-00003

    authors: Jakobs R,Hartmann D,Kudis V,Eickhoff A,Schilling D,Weickert U,Siegler KE,Riemann JF

    更新日期:2006-05-01 00:00:00

  • Infliximab in refractory coeliac disease.

    abstract::Coeliac disease is generally well controlled with gluten-free diet but a small proportion of patients require corticosteroids or immunomodulatory agents. Response to anti-tumour necrosis factor (anti-TNF) agents raises interesting questions about both the pathogenesis of coeliac disease and the mechanism of action of ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200506000-00002

    authors: Chaudhary R,Ghosh S

    更新日期:2005-06-01 00:00:00

  • High-flow-rate haemodiafiltration as a brain-support therapy proceeding to liver transplantation for hyperacute fulminant hepatic failure.

    abstract::In fulminant hepatic failure (FHF), rapidly progressive cerebral oedema remains the main fatal complication and an obstacle in liver transplantation. A 29-year-old Japanese woman presented with sudden-onset hepatic encephalopathy and jaundice. Hepatic encephalopathy deteriorated within 2 days of the onset of jaundice....

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200204000-00018

    authors: Sadamori H,Yagi T,Inagaki M,Shima Y,Matsuda H,Tanaka N,Sakaguchi K,Tsuji T,Matsumi M,Katayama H,Hirakawa N

    更新日期:2002-04-01 00:00:00

  • Spontaneous bacterial peritonitis caused by quinolone-resistant Escherichia coli: could steroid therapy play a role?

    abstract::Prophylaxis with norfloxacin has been shown to be effective in preventing spontaneous bacterial peritonitis (SBP) in liver cirrhosis. This therapy is associated with the appearance of quinolone-resistant Escherichia coli. However, only four cases of SBP caused by quinolone-resistant E. coli have been reported so far. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200201000-00014

    authors: Cereto F,Genescà J,Smithson A,González A,Moreno G,del Valle Ortiz O,Esteban R,Guardia J

    更新日期:2002-01-01 00:00:00

  • Eosinophilic gastroenteritis.

    abstract::Eosinophilic gastroenteritis is a rare disease of unknown aetiology characterized by eosinophilic infiltration of the gastrointestinal wall and increased peripheral blood eosinophilia. The frequent finding of concomitant extradigestive involvement calls for differential diagnosis to distinguish some multisystemic path...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199705000-00022

    authors: Malaguarnera M,Restuccia N,Pistone G,Panebianco MP,Giugno I,Grasso G,Seminara G

    更新日期:1997-05-01 00:00:00

  • Feasibility and long-term evolution of TIPS in cirrhotic patients with portal thrombosis.

    abstract:AIM:Many researchers consider portal thrombosis (PT) as a contraindication to transjugular intrahepatic portosystemic shunt (TIPS). The aim of this retrospective study was to compare the feasibility and long-term prognosis of TIPS in cirrhotic patients, with and without, complete PT. PATIENTS AND METHODS:Four hundred ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328338d995

    authors: Perarnau JM,Baju A,D'alteroche L,Viguier J,Ayoub J

    更新日期:2010-09-01 00:00:00

  • Impact of nitazoxanide on sustained virologic response in Egyptian patients with chronic hepatitis C genotype 4: a double-blind placebo-controlled trial.

    abstract:BACKGROUND:Nitazoxanide, approved for the treatment of Cryptosporidium parvum and Giardia lamblia, was found to inhibit hepatitis C virus replication. AIM:The aim of this study was to assess the impact of nitazoxanide as an add-on therapy to pegylated interferon α-2a and ribavirin on sustained virologic response (SVR)...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0000000000000492

    authors: Kohla MA,El-Said H,El-Fert A,Ehsan N,Ezzat S,Taha H

    更新日期:2016-01-01 00:00:00

  • Effect of Helicobacter pylori eradication on the healing and recurrence of peptic ulcer: combination therapy with low-dose omeprazole and clarithromycin.

    abstract:AIM:To investigate the effect of eradication of Helicobacter pylori using combination therapy with low-dose omeprazole and clarithromycin on the healing and recurrence of peptide ulcers. PATIENTS AND METHODS:We studied 60 patients with active duodenal ulcers and 60 with gastric ulcers who were H. pylori-positive by th...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Uemura N,Okamoto S,Mukai T,Yamaguchi S,Kaji M,Hrruma K,Sumii K,Kajiyama G

    更新日期:1995-08-01 00:00:00

  • Effects of a supplementary diet with specially processed cereals in patients with short bowel syndrome.

    abstract:OBJECTIVE:Short bowel syndrome patients frequently experience impaired health-related quality of life. This syndrome is also associated with increased costs for the individuals concerned and the community. Intake of specially processed cereals has been demonstrated to decrease intestinal secretion. This study evaluates...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MEG.0b013e328303c00a

    authors: Pagoldh M,Eriksson A,Heimtun E,Kvifors E,Sternby B,Blomquist L,Lapidus A,Suhr O,Lange S,Karlbom U,Nordström D,Rettrup B

    更新日期:2008-11-01 00:00:00

  • Autoimmune pancreatitis: increasing evidence for a clinical entity with various patterns.

    abstract::Autoimmune pancreatitis is a clinical entity with many different clinical and biological characteristics that make diagnosis difficult. Sensitive and specific pancreatic antibodies are still lacking to assess the diagnosis as is the availability of interpretable pathological specimens. However, suggestive features con...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-200412000-00005

    authors: Sahel J,Barthet M,Gasmi M

    更新日期:2004-11-01 00:00:00

  • Ambulatory seton placement followed by fistulotomy: efficacy and safety for perianal fistula treatment.

    abstract:PURPOSE:To evaluate the efficacy and safety of ambulatory seton placement followed by superficial fistulotomy as treatment of perianal fistula. METHODS:Retrospective observational analysis of patients with cryptogenic perianal fistula aged 18-90 years, followed in a central hospital proctology consultation between 200...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001913

    authors: Gamelas V,Simões G,Santos S,Loureiro R,Seves I,Costa Simões J,David Marques A,Bettencourt MJ

    更新日期:2020-09-09 00:00:00

  • Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study.

    abstract:UNLABELLED:There are no solid figures of the frequency of ulcer disease during childhood in Europe. We assessed its frequency and analyzed known risk factors. PATIENTS AND METHODS:Ulcers, erosions, indications, and risk factors were recorded in all children undergoing an upper gastrointestinal endoscopy in a prospecti...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e32833d36de

    authors: Kalach N,Bontems P,Koletzko S,Mourad-Baars P,Shcherbakov P,Celinska-Cedro D,Iwanczak B,Gottrand F,Martinez-Gomez MJ,Pehlivanoglu E,Oderda G,Urruzuno P,Casswall T,Lamireau T,Sykora J,Roma-Giannikou E,Veres G,Wewer V,Ch

    更新日期:2010-10-01 00:00:00

  • Helicobacter pylori infection after partial gastrectomy for peptic ulcer and its role in relapsing disease.

    abstract:OBJECTIVE:To elucidate the role of Helicobacter pylori in relapsing disease after partial gastrectomy for peptic ulcer. DESIGN:Retrospective study of gastroscopies between January 1985 and February 1988. SETTING:Department of Surgery, Helsinki University Central Hospital, Finland. PARTICIPANTS:One hundred and fifty-...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Leivonen MK,Haglund CH,Nordling SF

    更新日期:1997-04-01 00:00:00

  • Cutaneous amyloidosis associated with primary biliary cirrhosis.

    abstract::Primary cutaneous amyloidosis is defined as the deposition of amyloid in the skin in the absence of systemic involvement. The association between primary cutaneous amyloidosis and other diseases, although rare, has been documented for connective tissue disorders such as systemic sclerosis, systemic lupus erythematosus...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32811ec024

    authors: Tafarel JR,Lemos LB,Oliveira PM,Lanzoni VP,Ferraz ML

    更新日期:2007-07-01 00:00:00

  • Granulocyte colony-stimulating factor improves function of neutrophils from patients with acute liver failure.

    abstract:OBJECTIVE:To evaluate the in vitro effects of granulocyte colony-stimulating factor (G-CSF) on function of neutrophils in acute liver failure (ALF). METHODS:Neutrophil functions (superoxide and hydrogen peroxide production; phagocytosis and killing; complement receptor expression) were determined simultaneously in 23 ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012100-00011

    authors: Rolando N,Clapperton M,Wade J,Panetsos G,Mufti G,Williams R

    更新日期:2000-10-01 00:00:00

  • Influence of biliary anastomosis on recovery from secondary biliary cirrhosis.

    abstract:OBJECTIVE:The influence of choledochoduodenostomy and choledochojejunostomy on the repair of hepatic lesions secondary to biliary obstruction is not well known. The aim of the present study was to compare the effects of choledochoduodenostomy and choledochojejunostomy on the recovery of these lesions in rats with bilia...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3283551fed

    authors: dos Santos JS,Kemp R,de Andrade MF,Neder L

    更新日期:2012-09-01 00:00:00

  • Resolution of a complex mediastinal pseudocyst in a patient with alcohol-related chronic pancreatitis following abstinence from alcohol.

    abstract::We describe a 55-year-old patient with alcoholic chronic pancreatitis, a large mediastinal pseudocyst and a hemorrhagic pleural effusion. A single thoracocentesis and withdrawal of alcohol without other conservative or invasive measures resulted in a complete resolution of the pleural effusion and the mediastinal pseu...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200601000-00020

    authors: Groeneveld JH,Tjong A Lieng JG,de Meijer PH

    更新日期:2006-01-01 00:00:00

  • Vitamin B12 absorption after ileorectal anastomosis for Crohn's disease: effect of ileal resection and time span after surgery.

    abstract:OBJECTIVE:To examine the impact of ileorectal anastomosis on vitamin B12 absorption, as measured by the Schilling test, in patients with Crohn's disease. PATIENTS:Eighty-two patients with Crohn's disease who had undergone ileorectal anastomosis. METHODS:Of the 82 patients with Crohn's disease and ileorectal anastomos...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Behrend C,Jeppesen PB,Mortensen PB

    更新日期:1995-05-01 00:00:00

  • Colonic wall thickening is related to age and not dose of high strength pancreatin microspheres in children with cystic fibrosis.

    abstract:OBJECTIVE:Colonic fibrosis causing stricture is a recently described complication in cystic fibrosis (CF). Studies have suggested that ultrasound evidence of bowel thickening predicts this complication and that it is prevalent among children receiving large doses of high-strength pancreatin preparations. We performed u...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199902000-00020

    authors: Connett GJ,Lucas JS,Atchley JT,Fairhurst JJ,Rolles CJ

    更新日期:1999-02-01 00:00:00

  • The association of nonalcoholic fatty liver disease with genetic polymorphisms: a multicenter study.

    abstract:INTRODUCTION:Growing evidence suggests that multiple factors, such as insulin resistance, nutritional factors, gut microbiota, and hormones released from the adipose tissue, act together on genetically predisposed individuals. We aimed to investigate whether various single-nucleotide polymorphisms (SNPs) play a role in...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0000000000000813

    authors: Uygun A,Ozturk K,Demirci H,Oztuna A,Eren F,Kozan S,Yilmaz Y,Kurt O,Turker T,Vatansever S,Alper E,Unsal B

    更新日期:2017-04-01 00:00:00

  • Risk factors for high-grade dysplasia or carcinoma in colorectal adenoma cases treated with endoscopic polypectomy.

    abstract:OBJECTIVE:Our aim is to establish the risk factors for carrying high-grade dysplasia or carcinoma by analyzing endoscopically treated adenoma cases. METHODS:Patients who underwent endoscopic polypectomy at our hospitals between January 2003 and August 2004 were analyzed. RESULTS:A total of 889 patients (mean age: 63+...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e3282f1cbef

    authors: Kurome M,Kato J,Nawa T,Fujimoto T,Yamamoto H,Shiode J,Wato M,Kuwaki K,Okada H,Sakaguchi K,Shiratori Y

    更新日期:2008-02-01 00:00:00