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Ablation perioperative dabigatran in use envisioning in Japan: The ABRIDGE-J Study Design.

Abstract：

BACKGROUND:Catheter ablation has become a standard treatment strategy for drug-resistant symptomatic non-valvular atrial fibrillation (NVAF). Periprocedural administration of uninterrupted warfarin could reduce the risk of thromboembolic complications. However, only a few retrospective studies have reported on the efficacy and safety of periprocedural dabigatran use. METHOD:ABRIDGE is a prospective, randomized, parallel-group, controlled study that aims to evaluate the efficacy and safety of dabigatran compared with warfarin during the perioperative period of catheter ablation. Patients with drug-resistant paroxysmal NVAF from multiple Japanese ablation centers will be randomized using a 1:1 matrix. The main outcome measures include the incidence of embolism during the perioperative period and presence or absence of an intracardiac thrombus just before ablation. The secondary outcome measures include the incidence of all types of bleeding during the perioperative period, incidence of bleeding or thromboembolic events during the perioperative period and within 6 months after the procedure, duration of hospitalization, vascular death, all-cause mortality, net clinical benefit, and all adverse events. CONCLUSION:In this study, we aim to evaluate the efficacy and safety of dabigatran compared with warfarin during the perioperative period in candidates for catheter ablation of NVAF. Moreover, we hope to obtain objective data that may guide the selection and usage of anticoagulants during catheter ablation.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Goya M,Nogami A,Hirao K,Aonuma K

doi

10.1016/j.jjcc.2015.10.003

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

236-40

issue

3

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(15)00320-2

journal_volume

68

pub_type

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