Abstract:
OBJECTIVES:The aim of this study was to assess the relationship between the pericardial fat volume (PFV) and the characteristics of coronary plaques in patients with ischemic heart disease (IHD). BACKGROUND:It has been suggested that pericardial adipose tissue promotes plaque development in coronary artery disease (CAD). METHODS:We analyzed the cardiac computed tomography scans in consecutive patients suspected of CAD. PFV was quantified using validated software and indexed to body surface area, and the severity of coronary stenosis was evaluated in the patients who underwent coronary angiography. A total of 105 subjects (mean age, 68±10 years) with IHD were categorized into tertiles of body surface area-indexed PFV values (PFVi, cm3/m2): low-tertile, PFVi < 81.2 cm3/m2; mid-tertile, 81.2 cm3/m2 ≤ PFVi ≤ 114 cm3/m2; high-tertile, PFVi > 114 cm3/m2. Their body mass index (BMI), waist circumference, Gensini score (GS), and coronary plaque component were evaluated. RESULTS:The GS was significantly different between the high-tertile and the low-tertile groups, indicating a stepwise decrease in GS from high-tertile to mid-tertile and to low-tertile. PFVi had a significant positive correlation with BMI (p=0.0001) and GS (p<0.0001). However, no significant association was found between GS and BMI. On the multivariate analysis, high PFVi remained an independent predictor for the coronary artery disease severity (p<0.001), while BMI and waist circumference were not independent predictors. CONCLUSIONS:Obese patients were found to have more PFVi, and the characteristics of their coronary lesions were more severe. Pericardial adipose tissue as unique ectopic fat might be more highly associated with IHD progression.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Okura K,Maeno K,Okura S,Takemori H,Toya D,Tanaka N,Miyayama Sdoi
10.1016/j.jjcc.2014.03.015subject
Has Abstractpub_date
2015-01-01 00:00:00pages
37-41issue
1eissn
0914-5087issn
1876-4738pii
S0914-5087(14)00117-8journal_volume
65pub_type
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doi:
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journal_title:Journal of cardiology
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doi:
更新日期:1988-12-01 00:00:00
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journal_title:Journal of cardiology
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journal_title:Journal of cardiology
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doi:
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doi:10.1016/j.jjcc.2014.10.010
更新日期:2015-07-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
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journal_title:Journal of cardiology
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doi:
更新日期:1999-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jjcc.2011.01.012
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Apixaban, one of the non-vitamin K antagonist oral anticoagulants, was reported to be effective and safe in stroke prevention in patients with atrial fibrillation (AF) based on the global randomized clinical trial, but data are limited on the efficacy and safety of apixaban in Japanese elderly patients. MET...
journal_title:Journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jjcc.2015.12.006
更新日期:2016-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract::The floppy mitral valve prolapses into the left atrium in such a dynamic manner that the prolapsing floppy mitral valve becomes a space-occupying lesion within the left atrium. A significant result of the floppy mitral valve prolapsing into the left atrium during left ventricular systole is the development of a "third...
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doi:
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pub_type: 杂志文章
doi:10.1016/j.jjcc.2015.10.019
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doi:
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doi:10.1016/j.jjcc.2018.11.009
更新日期:2019-05-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2012.05.003
更新日期:2012-09-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2013.06.008
更新日期:2014-01-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2015.06.010
更新日期:2016-05-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-10-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::The usefulness of electrophysiologic study and Holter monitoring for predicting the long-term efficacy of amiodarone was investigated in 31 patients with sustained ventricular tachycardia (VT) and organic heart disease. Patients underwent both electrophysiologic study and Holter monitoring before and during oral admin...
journal_title:Journal of cardiology
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-11-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2014.09.010
更新日期:2015-07-01 00:00:00