Abstract:
BACKGROUND:Apixaban, one of the non-vitamin K antagonist oral anticoagulants, was reported to be effective and safe in stroke prevention in patients with atrial fibrillation (AF) based on the global randomized clinical trial, but data are limited on the efficacy and safety of apixaban in Japanese elderly patients. METHODS AND RESULTS:The J-ELD AF Registry is a large-scale, contemporary observational study, continuously and prospectively registering elderly Japanese patients with AF aged 75 years or older who are currently taking apixaban or the elderly who are to receive apixaban in daily clinical practice, and accumulating the outcomes during one-year follow-up period. In addition to standard baseline characteristics, prothrombin time and anti-Xa activity will be measured to investigate the biomarker characteristics. The primary efficacy endpoints will be stroke and systemic embolism, and the primary safety endpoint will be major bleeding requiring hospitalization. The secondary endpoints in this study will be all-cause death, cardiovascular death, acute myocardial infarction, and the composite of stroke/systemic embolism, cardiovascular death, and acute myocardial infarction. As a primary analysis, the primary/secondary endpoints in the enrolled patients will be totalized for the entire group, and the incidence of events will be described by age, CHADS2 score, HAS-BLED score, and apixaban dose (5 or 2.5mg bid). The factors that independently predict the incidence of the primary/secondary endpoints will be searched for by Cox regression. The relationship between the biomarkers and the primary/secondary endpoints will also be examined in an explorative manner. CONCLUSION:This study will provide important information on the efficacy and safety of apixaban in elderly Japanese patients aged 75 years or older, and those of low-dose administration of apixaban (2.5mg bid) for which many of the Japanese elderly are indicated.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Akao M,Yamashita T,Okumura K,J-ELD AF Investigators.doi
10.1016/j.jjcc.2015.12.006subject
Has Abstractpub_date
2016-12-01 00:00:00pages
554-558issue
6eissn
0914-5087issn
1876-4738pii
S0914-5087(15)00404-9journal_volume
68pub_type
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journal_title:Journal of cardiology
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更新日期:1991-01-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
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journal_title:Journal of cardiology
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doi:
更新日期:1988-12-01 00:00:00
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doi:
更新日期:1989-03-01 00:00:00
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更新日期:2002-06-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
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doi:
更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
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doi:
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pub_type: 杂志文章
doi:
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journal_title:Journal of cardiology
pub_type: 临床试验,杂志文章
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更新日期:1995-12-01 00:00:00
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