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Effects of eicosapentaenoic acid on peri-procedural (type IVa) myocardial infarction following elective coronary stenting.

Abstract：

OBJECTIVES:The aim of this study was to assess the effect of eicosapentaenoic acid (EPA) on peri-procedural (type IVa) myocardial infarction (MI) following elective percutaneous coronary intervention (PCI). METHODS AND RESULTS:We analyzed data from 165 of 178 consecutive patients with stable angina pectoris who underwent de novo successful stent implantation in the native coronary artery. Patients were assigned to receive statin therapy in combination with 1800mg/day of EPA or statin alone. Post-procedural index of microcirculatory resistance (IMR) values were calculated for 30 patients in the EPA group and 32 controls. In the multivariate logistic model, EPA administration, low kidney function, and the presence of slow flow/no reflow were significantly and independently associated with type IVa MI. Post-procedural IMR values were significantly lower in the EPA group [19.8 (6.4, 51.1) vs. 27.8 (8.2, 89.3), p=0.003] compared to the control group. CONCLUSIONS:Pre-treatment with EPA in addition to statins significantly reduced the incidence of type IVa MI compared to statin therapy only, which may be attributed to the ability of EPA to reduce microvascular dysfunction induced by PCI.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Kurita A,Takashima H,Ando H,Kumagai S,Waseda K,Gosho M,Amano T

doi

10.1016/j.jjcc.2014.09.004

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

114-9

issue

2

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(14)00279-2

journal_volume

66

pub_type

临床试验,杂志文章

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