Abstract:
BACKGROUND:Syndecan-4 is a transmembrane heparan sulfate-carrying glycoprotein that mediates signal transduction pathways activated by growth factors and cell surface receptors, thereby modulating tissue regeneration, angiogenesis, and focal adhesion. The aim of the present study was to determine the clinical use of serum syndecan-4 concentration for diagnosis of heart failure. METHODS:Concentration of serum syndecan-4 and other biomarkers of heart failure was measured in 45 patients with heart failure and 21 healthy subjects. Clinical and echocardiographic parameters of cardiac function were recorded. RESULTS:Serum syndecan-4 concentration significantly increased in proportion to the decrease in ejection fraction (r=-0.599, p<0.001) and increase in the left ventricular (LV) mass index (r=0.315, p<0.05). Serum syndecan-4 concentration was significantly correlated with LV geometrical parameters (i.e. LV mass index, LV end-diastolic volume, and LV dimension), while B-type natriuretic peptide (BNP) was significantly correlated with pressure-related parameters [i.e. early transmitral flow velocity/early diastolic velocity of the mitral valve annulus (E/e'), right ventricular systolic pressure, and left atrial volume index]. Syndecan-4 concentration did not significantly correlate with plasma BNP, transforming growth factor-1, matrix metalloproteinase-2, and tenascin-C concentrations. Serum syndecan-4 concentration could predict cardiac death and re-hospitalization due to heart failure (area under curve, 0.706, p<0.05). CONCLUSION:Serum syndecan-4 concentration shows promise as a novel diagnostic and prognostic biomarker for heart failure. Since syndecan-4 correlated with LV geometrical rather than hemodynamic parameters, serum syndecan-4 may represent a biomarker of LV remodeling in the failing heart.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Takahashi R,Negishi K,Watanabe A,Arai M,Naganuma F,Ohyama Y,Kurabayashi Mdoi
10.1016/j.jjcc.2011.01.012subject
Has Abstractpub_date
2011-05-01 00:00:00pages
325-32issue
3eissn
0914-5087issn
1876-4738pii
S0914-5087(11)00016-5journal_volume
57pub_type
杂志文章abstract:OBJECTIVES:Although physicians frequently perform palpation of the apex beat to evaluate left ventricular (LV) size and hypertrophy, the clinical significance of apex beat palpation is still unclear. The introduction of multislice computed tomography (MSCT) has enabled assessment not only of coronary stenoses but also ...
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abstract::A Genesis stent was implanted in two children, one with superior vena caval (SVC) stenosis and one with pulmonary artery branch stenosis. Case 1 was a 2-month-old baby with SVC stenosis following intracardiac repair for total anomalous pulmonary venous connection (TAPVC) and case 2 was a 2-year-old child with left low...
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pub_type: 临床试验,杂志文章
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更新日期:2006-05-01 00:00:00
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更新日期:2005-05-01 00:00:00
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更新日期:2013-10-01 00:00:00
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更新日期:2016-03-01 00:00:00
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更新日期:2003-06-01 00:00:00
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doi:
更新日期:1995-04-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
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doi:
更新日期:2006-11-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jjcc.2012.05.003
更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jjcc.2014.05.004
更新日期:2015-02-01 00:00:00
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更新日期:2020-07-01 00:00:00
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更新日期:2020-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jjcc.2013.01.002
更新日期:2013-05-01 00:00:00
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更新日期:2006-01-01 00:00:00
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doi:
更新日期:1994-05-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jjcc.2012.05.004
更新日期:2012-10-01 00:00:00
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doi:
更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Journal of cardiology
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