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MicroRNAs: Emerging biomarkers for atrial fibrillation.

Abstract：

:Atrial fibrillation (AF) causes severe cardiac dysrhythmia among patients with cardiovascular diseases. AF increases the risk of stroke and heart failure and is a growing public health concern. AF is also associated with various disease conditions such as hypertension, coronary artery disease, aging, and diabetes mellitus. The mechanism underlying AF is not completely understood due to its complexity. However, experimental and clinical data have revealed that the prevalence of this disease is associated with atrial arrhythmogenic remodeling. Currently, there are no biomarkers that are available for the early diagnosis of AF. Several studies have proposed microRNAs (miRNAs) as useful biomarkers for the diagnosis of AF due to their stability and easy availability both in atrial tissue and circulating blood. miRNAs play an important role in the development of the heart. The dysregulation of miRNA expression is associated with cardiac remodeling. Genetic factors strongly contribute to the pathogenesis of AF. Recently, single nucleotide polymorphisms (SNPs) in various genes and miRNAs have been reported to be associated with AF. The aim of this review was to discuss the correlation between SNPs in miRNAs and AF, including those miRNAs that are commonly reported as potential biomarkers for AF.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Komal S,Yin JJ,Wang SH,Huang CZ,Tao HL,Dong JZ,Han SN,Zhang LR

doi

10.1016/j.jjcc.2019.05.018

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

475-482

issue

6

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(19)30204-7

journal_volume

74

pub_type

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