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Ongoing myocardial damage in patients with heart failure and preserved ejection fraction.

Abstract：

BACKGROUND:The relationship between ongoing myocardial damage and heart failure with preserved left ventricular systolic function (HF-PEF) is still unclear. To investigate this relationship, we measured the cardiac-specific cytosolic marker, heart-type fatty acid binding protein (H-FABP), and a myofibrillar component (troponin T), and analyzed clinical outcomes. METHODS AND RESULTS:Consecutive heart failure patients (n=151) with echocardiographic left ventricular ejection fraction >50% were prospectively enrolled. The cut-off values for myocardial membrane injury (H-FABP >4.3 ng/mL) and myofibrillar injury (troponin T >0.01 ng/mL) were defined using receiver operating characteristic curves. Myocardial membrane injury was observed more frequently than myofibrillar injury (41% vs. 26% of patients, p<0.05). Patients were followed up for a median of 694 days, with the end-points being cardiovascular death or re-hospitalization. By multivariate analysis, the serum H-FABP level was an independent predictor of cardiovascular events (hazard ratio 1.165 per 1 ng/mL increase, 95% confidence interval 1.034-1.314, p=0.012). CONCLUSIONS:Latent myocardial injury was frequently observed in patients with HF-PEF. The circulating H-FABP level was an independent predictor of subsequent cardiovascular events.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Kutsuzawa D,Arimoto T,Watanabe T,Shishido T,Miyamoto T,Miyashita T,Takahashi H,Niizeki T,Takeishi Y,Kubota I

doi

10.1016/j.jjcc.2012.06.006

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

454-61

issue

6

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(12)00118-9

journal_volume

60

pub_type

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