Abstract:
:To ascertain the relationship between the types of myocardial perfusion defects and supraventricular and ventricular tachyarrhythmias in hypertrophic cardiomyopathy (HCM), 26 patients were studied with dipyridamole-loading thallium-201 scintigraphy and the results were correlated with 24-hour ambulatory ECG, echocardiograms and hemodynamic data. Myocardial perfusion defects were detected in 10 of the 26 patients (38%); three with large defects (LD) and seven with multiple small defects (SD). The patients with defects had greater degree of asymmetric septal hypertrophy (1.82 +/- 0.49 vs 1.27 +/- 0.38, p less than 0.01) and lower cardiac indices (2.35 +/- 0.31 vs 2.70 +/- 0.43, p less than 0.05) than did the patients without defects. Paroxysmal atrial fibrillation (PAf) and/or paroxysmal supraventricular tachycardia (PSVT) were observed in six of the 10 patients with defects (60%) and in four of the 16 patients without defects (25%). Ventricular tachycardia (VT) was identified in six of the 10 patients with defects (60%) but in only three of the 16 patients without defects (19%) (p less than 0.05). Among 10 patients with defects, PAf and/or PSVT were present in six of the seven patients with SD, but not in any of the patients with LD (p less than 0.05). VT was present in five of the seven patients with SD and in one of the three patients with LD. In conclusion, 1) perfusion defects in HCM are associated with greater degree of asymmetric septal hypertrophy, the lower cardiac indices, and higher prevalences of PAf, PSVT and VT; 2) Perfusion defects can be classified in two types; ie., multiple small defects and large defects; 3) Patients with multiple small defects commonly have PAf, PSVT as well as VT. This correlation may be of clinical importance, particularly in evaluating the causes of the defects and mechanisms of these arrhythmias.
journal_name
J Cardioljournal_title
Journal of cardiologyauthors
Doi Y,Yonezawa Y,Chikamori T,Hamashige N,Kuzume O,Takata J,Yamada M,Ozawa Tsubject
Has Abstractpub_date
1989-12-01 00:00:00pages
1089-98issue
4eissn
0914-5087issn
1876-4738journal_volume
19pub_type
杂志文章abstract::To define the histopathogenesis of successful and unsuccessful recanalization following selective intracoronary thrombolysis, coronary angiography (CAG) in thrombolysis and histologic findings were compared in 13 patients who died within four days (mean 1.5 days) after the procedure. Thirteen infarct-related arteries ...
journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::Thallium-201 myocardial imaging was performed in 150 patients with a history of Kawasaki disease, aged 6 months to 16 years old. Forty-five patients were studied with ergometer exercise and 105 patients had dipyridamole administration. The findings of thallium imaging were compared with those of coronary angiography. ...
journal_title:Journal of cardiology
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:Journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jjcc.2012.02.011
更新日期:2012-08-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jjcc.2012.08.009
更新日期:2012-11-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2012.12.003
更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-12-18 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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更新日期:2020-07-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2013.07.007
更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jjcc.2008.10.003
更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.jjcc.2015.12.006
更新日期:2016-12-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.jjcc.2013.02.015
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The correlations between genotype and phenotype in hypertrophic cardiomyopathy (HCM) have not been established. Mutation of α-actin gene (ACTC1) is a rare cause of HCM. This study aimed to explore novel genotype-phenotype correlations in HCM patients with the variants in ACTC1 and myosin-binding protein (MYB...
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更新日期:2019-05-01 00:00:00
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更新日期:2020-11-30 00:00:00
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更新日期:2004-11-01 00:00:00
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journal_title:Journal of cardiology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00