Abstract：
AIM:To examine the functional brain alterations in Parkinson's disease (PD) by measuring blood oxygenation level dependent (BOLD) functional MRI (fMRI) signals at rest while controlling for the structural atrophy. MATERIALS AND METHODS:Twenty-three PD patients and 20 age, gender, and education level matched normal controls (NC) were included in this study. Resting state fMRI and structural MRI data were acquired. The resting state brain activity was measured by the regional homogeneity (ReHo) method and the grey matter (GM) volume was attained by the voxel-based morphology (VBM) analysis. Two-sample t-test was then performed to detect the group differences with structural atrophy as a covariate. RESULTS:VBM analysis showed GM volume reductions in the left superior frontal gyrus, left paracentral lobule, and left middle frontal gyrus in PD patients as compared to NC. There were widespread ReHo differences between NC and PD patients. Compared to NC, PD patients showed significant alterations in the motor network, including decreased ReHo in the right primary sensory cortex (S1), while increased ReHo in the left premotor area (PMA) and left dorsolateral prefrontal cortex (DLPFC). In addition, a cluster in the left superior occipital gyrus (SOG) also showed increased ReHo in PD patients. CONCLUSION:The current findings indicate that significant changes of ReHo in the motor and non-motor cortices have been detected in PD patients, independent of age, gender, education level, and structural atrophy. The present study thus suggests ReHo abnormalities as a potential biomarker for the diagnosis of PD and further provides insights into the biological mechanism of the disease.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Li Y,Liang P,Jia X,Li Kdoi
10.1016/j.crad.2015.10.006subject
Has Abstractpub_date
2016-01-01 00:00:00pages
e28-34issue
1eissn
0009-9260issn
1365-229Xpii
S0009-9260(15)00393-1journal_volume
71pub_type
杂志文章abstract：AIM:To use sound touch elastography (STE) to assess the changes of renal cortex among different complications following renal transplantation. MATERIALS AND METHODS:A total of 31 patients with renal dysfunction after renal transplantation underwent an ultrasound-guided biopsy for pathological examination with conventi...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2020.08.013
更新日期：2020-12-01 00:00:00
abstract：:A low speed rotational catheter system (ROTACS) was used to recanalize total occlusions of the femoropopliteal artery in two patient groups. In Group A, previous attempts to recanalize the occlusions using standard guidewires and catheters had failed. Group B had undergone no previous attempts at recanalization. The R...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)81791-x
更新日期：1994-05-01 00:00:00
abstract：AIM:To analyse lower limb angioplasty results using the defined anatomical classification of the Trans-Atlantic Inter-Society Consensus (TASC) in a training environment and to compare the results with published data. MATERIALS AND METHODS:Retrospective, consecutive data were collected for a period of 1 year for all pa...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2011.12.011
更新日期：2012-10-01 00:00:00
abstract：:Primary cardiac neoplasms are extremely rare and are far outnumbered by metastases. These are difficult to diagnose and differentiate clinically due to lack of specific clinical manifestations. Technological advances have revolutionised cardiac imaging, with the cardiac magnetic resonance imaging (CMRI) showing promis...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2019.11.014
更新日期：2020-04-01 00:00:00
abstract：:We have assessed the diagnostic accuracy of a flat or concave left mid-cardiac border (the region of the left atrial appendage) on conventional postero-anterior chest radiographs as a predictor of the presence of thrombi in the left atrium or its appendage in 80 patients with rheumatic mitral stenosis who subsequently...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)80543-4
更新日期：1991-05-01 00:00:00
abstract：:A wide range of pathologies may arise from the submandibular space (SMS) or submandibular gland (SMG) in children. We review herein the normal anatomy of the SMS and describe the role of imaging in the evaluation of SMS lesions. A schematic approach for the categorisation of SMS pathology based on imaging characterist...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2015.03.003
更新日期：2015-07-01 00:00:00
abstract：AIM:To compare combined 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron-emission tomography (PET) and cardiac magnetic resonance imaging (CMR) for the diagnosis and therapy monitoring of cardiac sarcoidosis (CS). MATERIALS AND METHODS:Eighty patients with sarcoidosis and a suspicion of CS who underwent PET and CMR wer...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2018.09.015
更新日期：2019-01-01 00:00:00
abstract：:A prospective study was performed in 138 consecutive patients referred for small-bowel examination to evaluate the use of the pneumocolon when there was poor demonstration of the terminal ileum. One hundred and twenty-two patients were examined by enteroclysis (small-bowel enema) and 16 by small-bowel meal. Pneumocolo...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(85)80253-1
更新日期：1985-11-01 00:00:00
abstract：:Sixty patients admitted with a clinical diagnosis of pulmonary embolism underwent a prospective analysis of the value of lung ventilation/perfusion scintigraphy and lower limb colour flow venous Doppler. Twenty-two per cent of scintigrams gave a high probability of pulmonary embolus (PE) and 45% a low probability/norm...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)83476-2
更新日期：1995-04-01 00:00:00
abstract：AIM:To identify characteristic high-resolution computed tomography (CT) findings for individual collagen vascular disease (CVD)-related interstitial pneumonias (IPs). MATERIALS AND METHODS:The HRCT findings of 187 patients with CVD, including 55 patients with rheumatoid arthritis (RA), 50 with systemic sclerosis (SSc)...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2018.04.017
更新日期：2018-09-01 00:00:00
abstract：:The experience of the British National Lymphoma Investigation in the treatment of 68 children with Hodgkin's disease is reported over a 14 year period from 1970. The presenting histology was reviewed by a single histopathologist; 87% of the cases were classified as nodular sclerosis (NS) and further subdivided into NS...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(87)80382-3
更新日期：1987-01-01 00:00:00
abstract：AIM:To evaluate the early treatment response to chemotherapy in patients with lung cancer using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Twenty-two patients with lung cancer underwent DCE-MRI before chemotherapy and 1 week after the start of the first course of chemothera...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2018.02.013
更新日期：2018-07-01 00:00:00
abstract：:Over a 12 month period all patients but one presenting to our hospital with occluded prosthetic grafts were treated by thrombolysis using local pulsed administration of tissue-type plasminogen activator (t-PA). There were 30 interventions in 23 patients but in one patient no thrombolytic was given after aspiration of ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)80683-x
更新日期：1992-12-01 00:00:00
abstract：AIM:To evaluate whether a simple pre-treatment regimen of sinus node inhibition by ivabradine taken at home for only 1 day resulted in a lower pre-scanning heart rate (HR) and reduced the need for intravenous beta-blockers (BB) prior to coronary computed tomography angiography (CTA). MATERIALS AND METHODS:The pre-trea...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2013.05.005
更新日期：2013-10-01 00:00:00
abstract：:Interventional approaches to musculoskeletal tumours have significantly changed over the last several years, and new treatments continue to be developed. All ablative modalities are currently applied to the treatment of bone tumours, including radiofrequency, cryo-, microwave, and laser ablation devices. Indications f...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2017.02.019
更新日期：2017-08-01 00:00:00
abstract：AIM:To establish whether non-contrast enhanced computed tomography (NCCT) renders the kidneys-ureters-bladder (KUB) radiograph redundant as the initial imaging investigation for suspected acute ureteric colic. MATERIALS AND METHODS:The imaging investigations for 120 patients consecutively admitted to an emergency depa...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2008.04.012
更新日期：2008-10-01 00:00:00
abstract：:The complication rate following radiofrequency catheter ablation for atrial fibrillation is low (<5%). Complications include pericardial effusion, cardiac tamponade, pulmonary vein stenosis, oesophageal ulceration or perforation, atrio-oesophageal fistula formation, stroke/transient ischaemic attack, phrenic nerve inj...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2013.08.018
更新日期：2014-01-01 00:00:00
abstract：:Digital imaging has shown rapid advances in recent years. Various different digital mammography systems are now available for clinical use. Digital mammography does have clear advantages over traditional screen film mammography, but this is yet to convincingly translate into improved cancer detection rates. This revie...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2003.08.011
更新日期：2004-01-01 00:00:00
abstract：:The creation of an intrahepatic portosystemic shunt via a transjugular approach (TIPS) is an interventional radiological procedure used to treat the complications of portal hypertension. TIPS insertion is principally indicated to prevent or arrest variceal bleeding when medical or endoscopic treatments fail, and in th...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2008.09.017
更新日期：2009-07-01 00:00:00
abstract：:Sarcoidosis is a relatively common disease with protean clinical manifestations. Involvement of the parotid glands in the acute presentation is well recognized but the grey scale and colour Doppler appearances are less well so. These are described in a case where imaging and biopsy proved valuable in the diagnosis of ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)81832-x
更新日期：1994-06-01 00:00:00
abstract：AIM:To describe the magnetic resonance imaging (MRI) appearances in patients with a clinical history suggestive of vertebral osteomyelitis and discitis who underwent MRI very early in their clinical course. MATERIALS AND METHODS:A retrospective review of the database of spinal infections from a spinal microbiological ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2010.03.015
更新日期：2010-12-01 00:00:00
abstract：AIM:To evaluate the technical feasibility of artificial ascites formation using an angiosheath before percutaneous radiofrequency ablation (RFA) for hepatic tumours and to determine predictive factors affecting the technical failure of artificial ascites formation. MATERIALS AND METHODS:This retrospective study was ap...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2014.07.012
更新日期：2014-12-01 00:00:00
abstract：:Thyroglossal fistulography is poorly documented in the radiological literature. An illustrative case is presented, highlighting the technique employed and the significance of its findings. The taste of contrast medium as it spills over the tongue is a useful additional sign in the successful demonstration of a fistulo...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)80017-0
更新日期：1992-04-01 00:00:00
abstract：:Ultrasound is a routine investigation for the assessment of scrotal masses. Many of the detected lesions involve the paratesticular structures. The most common paratesticular masses in clinical practice are epididymal cysts and spermatoceles, but there are a large number of other pathologies that can be encountered an...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2007.09.004
更新日期：2008-08-01 00:00:00
abstract：:Traditionally echocardiography has been the method of choice for the evaluation of pericardial and cardiac lesions. However, computed tomography (CT) and magnetic resonance imaging (MRI) provide a large field of view and excellent images of anatomy not available with echocardiography. In addition, CT and MRI demonstra...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2007.01.009
更新日期：2007-07-01 00:00:00
abstract：:Pelvic phleboliths were demonstrated in 1000 subjects aged 16--79 years (mean 42.1, s.d. 12.7). They occurred in 44.2% of the subjects, in 37.3% of the males and 50.1% of the females. Among subjects between the ages of 35 and 54, phleboliths occurred more frequently in the females than in the males. In addition the ol...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(80)80095-x
更新日期：1980-01-01 00:00:00
abstract：AIM:To investigate the feasibility of using a low-concentration test bolus in abdominal aorta computed tomography (CT) angiography (CTA). MATERIALS AND METHODS:In 10 patients referred for CTA of the abdominal aorta with a body mass index (BMI) ≤28 kg/m2, a standard test bolus of 10 ml contrast medium (CM; 350 mg iodin...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2016.08.008
更新日期：2016-12-01 00:00:00
abstract：:Clinical diagnosis of abdominal wall hernias can be challenging. These common entities can be symptomatic and prone to complications. Pre-surgical planning and investigation of acute presentations can be achieved by multidetector computed tomography (MDCT) with its added multiplanar reformatting capability. Here we de...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2012.07.016
更新日期：2013-04-01 00:00:00
abstract：:Chordoma is generally thought to be a locally invasive tumour of low metastatic potential. Review of the literature suggests that metastatic spread from chordoma is not an uncommon occurrence, but that the metastases are usually clinically silent. We present an unusual case where a metastasis from a sacrococcygeal cho...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)83143-5
更新日期：1995-06-01 00:00:00
abstract：AIM:To demonstrate the magnetic resonance imaging (MRI) appearances of intact and ruptured Trilucent TM implants with imaging and surgical correlation. The appearances of the implant transponder artefact are also described MATERIALS AND METHODS:A retrospective review of the MRI findings in 34 patients with bilateral s...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1053/crad.2001.0767
更新日期：2002-04-01 00:00:00
