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A pencil beam algorithm for magnetic resonance image-guided proton therapy.

Abstract：

PURPOSE:The feasibility of magnetic resonance image (MRI)-based proton therapy is based, among several other factors, on the implementation of appropriate extensions on current dose calculation methods. This work aims to develop a pencil beam algorithm (PBA) for dose calculation of proton beams within magnetic field regions of up to 3 T. METHODS:Monte Carlo (MC) simulations using the GATE 7.1/GEANT4.9.4p02 toolkit were performed to generate calibration and benchmarking data for the PBA. Dose distributions from proton beams in the clinical required energy range 60-250 MeV impinging on a 400 × 400 × 400 mm3 water phantom and transverse magnetic fields ranging from 0 to 3 T were considered. Energy depositions in homogeneous and heterogeneous phantoms filled with water, adipose, bone, and air were evaluated for proton energies of 80, 150, and 240 MeV, combining a trajectory calculation method and look-up tables (LUT). A novel parametrization model, using independent tailed Gauss fitting functions, was employed to describe the nonsymmetric shape of lateral beam profiles. Integrated depth-dose curves (IDD), lateral dose profiles, and two-dimensional dose distributions calculated with the PBA were compared with results from MC simulations to assess the performance of the algorithm. A gamma index criterion of 2%/2 mm was used for analysis. RESULTS:A close to perfect agreement was observed for PB-based dose calculations in water in magnetic fields of 0.5, 1.5, and 3 T. IDD functions showed differences between the PBA and MC of less than 0.1% before the Bragg peak, and deviations of 2-8% in the distal energy falloff region. Gamma index pass rates higher than 99% and mean values lower than 0.1 were encountered for all analyzed configurations. For homogeneous phantoms, only the full bone configuration offered deviations in the Bragg peak position of up to 1.7% and overestimations of the lateral beam spot width for high-energy protons and magnetic field intensities. An excellent agreement between PBA and MC dose calculation was also achieved using slab-like and lateral heterogeneous phantoms, with gamma index passing rates above 98% and mean values between 0.1 and 0.2. As expected, agreement reduced for high-energy protons and high-intensity magnetic fields, although results remained good enough to be considered for future implementation in clinical practice. CONCLUSIONS:The proposed pencil beam algorithm for protons can accurately account for dose distortion effects induced by external magnetic fields. The application of an analytical model for dose estimation and corrections reduces the calculation times considerably, making the presented PBA a suitable candidate for integration in a treatment planning system.

journal_name

Med Phys

journal_title

Medical physics

authors

Padilla-Cabal F,Georg D,Fuchs H

doi

10.1002/mp.12854

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

2195-2204

issue

eissn

0094-2405

issn

2473-4209

journal_volume

pub_type

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A pencil beam algorithm for magnetic resonance image-guided proton therapy.