Abstract:
:Clinical reports for Eleonora of Toledo (1522-1562), the wife of Cosimo I de' Medici, imply that during her 28th year she developed pulmonary tuberculosis, which was complicated by an attack of pernicious malaria, killing her at age 40. Eleonora's autopsy indicated that she had severe lung lesions consistent with chronic pulmonary infection. To clarify her disease status, we performed paleomolecular investigations. Our results identified ancient DNA from the Mycobacterium tuberculosis complex (MTB), along with Leishmania infantum (VL). Our data are of particular interest since in Tuscany the endemic foci of L. infantum are widely distributed and overlapped with those of malaria prior to its eradication. Although we can only speculate about Eleonora's true state of health, this clear evidence of long-term co-infection with MTB and VL is of major medical and biological interest since the co-evolution of the two pathogens and host-pathogen interactions in co-infected individuals are still not fully understood.
journal_name
Int J Paleopatholjournal_title
International journal of paleopathologyauthors
Bianucci R,Giuffra V,Bachmeier BE,Ball M,Pusch CM,Fornaciari G,Nerlich AGdoi
10.1016/j.ijpp.2012.11.002subject
Has Abstractpub_date
2012-12-01 00:00:00pages
231-235issue
4eissn
1879-9817issn
1879-9825pii
S1879-9817(12)00083-6journal_volume
2pub_type
杂志文章abstract::Alcohol Related Birth Defects (ARBD) are yet undocumented among past communities, although alcohol is the leading cause of non-heritable birth defects in the US today. We evaluate potential ARBD at Newton Plantation, Barbados (ca. 1660-1820), where earlier studies suggest frequent, community-wide consumption of lead-t...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.08.005
更新日期:2013-12-01 00:00:00
abstract::The soft tissue preservation system (STPS) is emerging as a method of expressing the degree of soft tissue present on an ancient human body (mummy). In this system the intact body is divided into five anatomic segments (head, thorax, pelvis, arms and legs). Each of these segments is assigned a maximal potential number...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2011.10.003
更新日期:2011-12-01 00:00:00
abstract::A Neolithic Belgian mandible from Bois Madame rockshelter in Arbre presents an asymmetrical morphology resulting from a secondary, or false, articulation of the right mandibular condyle. The pathological articulation produced enlarged masseter, medial pterygoid and mylohyoid musculature on the right side as well as a ...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2016.12.003
更新日期:2017-03-01 00:00:00
abstract::Here we evaluate Bhattacharya et al.'s (2018) recent paper "Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia" published in Genome Research. In this short report, we examine the hypothesis that the so-called "Atacama skeleton" has skeletal abnormalities indicative of dysplasia, cr...
journal_title:International journal of paleopathology
pub_type: 评论,杂志文章
doi:10.1016/j.ijpp.2018.06.007
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:Skeletons sampled for ancient human DNA analysis are sometimes complete enough to provide information about the lives of the people they represent. We focus on three Later Stone Age skeletons, ca. 2000 B.P., from coastal KwaZulu-Natal, South Africa, whose ancient genomes have been sequenced (Schlebusch et al., ...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2018.10.008
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To evaluate lesions on a cranium from the Iberian Peninsula and assess its medico-historical and paleopathological significance. MATERIALS:The skeletal remains of a juvenile individual found in a Medieval Islamic grave (10th -16th century) in Eastern Spain. METHODS:Macroscopic examination of the left and ri...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.10.009
更新日期:2020-11-21 00:00:00
abstract:OBJECTIVE:The aim of this paper was to analyse the dental remains of an adult male with three impacted canines from the Roman period cemetery in Osijek, Croatia. MATERIALS:The dental remains of an adult male aged 35-45 years at the time of death were analysed. METHODS:Macroscopic analysis of dental remains was accomp...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2018.10.004
更新日期:2019-03-01 00:00:00
abstract::We discuss here the differential diagnosis of carpal ankylosis along with the second and third metacarpals of the right hand in an adult male skeleton buried in a kurgan from Mayemer, Kazakhstan (86-242 AD, 95.4% cal.). Our assessment was conducted via macroscopic analysis as well as with the use of radiographic metho...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2015.11.004
更新日期:2016-03-01 00:00:00
abstract::We report the case of a probable meningioma in a cranium excavated from the Medieval site of Portmahomack on the Tarbat Peninsula in Scotland (Carver, 2008). Stratigraphic evidence enabled dating of the remains to a post-Pictish and pre-Reformation date. Meningiomas usually arise from the arachnoid membrane of the men...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2016.01.004
更新日期:2016-06-01 00:00:00
abstract::This is the first systematic large-scale palaeopathological study of adult vitamin D deficiency osteomalacia. One thousand one hundred and eighty-one skeletons from multiple urban contexts in post-mediaeval England (c. AD 1700-1855) were analysed. Twelve adults with evidence of osteomalacia were identified. When added...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2014.06.004
更新日期:2014-12-01 00:00:00
abstract::The analysis of 16th century graves from Zagreb, Croatia, revealed a case of frontal sinus osteoma in a middle-aged female. This lesion was discovered during visual examination, due to postmortem breakage of the frontal bone. The significance of this finding is based on the fact that frontal sinus osteomas are very ra...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.02.002
更新日期:2013-03-01 00:00:00
abstract::A description of the late mediaeval skeleton (AD 1150-1539) of a young child with probable signs of tuberculosis is presented. This individual was recovered along with one hundred and ninety skeletons from the cemetery of the priory of SS Peter and Paul, Taunton, Somerset. Aged between three and five years old at deat...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2012.04.001
更新日期:2012-03-01 00:00:00
abstract::Investigating injury recidivism and individuals with multiple injuries is an area of growing interest in bioarchaeology. Differentiating between whether an individual sustained multiple injuries, represented by antemortem healed fractures, in one incident or in multiple incidents over the life course, is a major chall...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2018.08.003
更新日期:2019-03-01 00:00:00
abstract::The identification of violence and trauma in an archaeological context requires a nuanced and detailed analysis of material culture and human remains. This paper focuses on sharp-force trauma data from individual skeletal elements for the Ancestral Pueblo site Peñasco Blanco (n=1301) and the epiclassic site La Quemada...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2012.09.015
更新日期:2012-01-01 00:00:00
abstract::Human and animal ectoparasites are often recovered from archaeological contexts being examined for preserved insect remains. Records of human lice, fleas and bedbugs are used to reconstruct past sanitary conditions and practices, as well as their geographic distribution and that of the pathogens for which they may be ...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.07.004
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE AND MATERIALS:This research evaluates the presence and chronology of tuberculosis (TB) in the northeastern highlands of Peru (CE 800-1535) through the analysis of osseous lesions from Pre-Contact Kuelap, Chachapoyas. METHODS:We examined macroscopic lesion morphology and distribution from the skeletal series ...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.04.002
更新日期:2020-09-01 00:00:00
abstract::This article considers the nature of written sources on the epidemiology of rickets in the post-Mediaeval period, and examines the value of these sources for palaeopathologists. There is a progression from 17th-18th century sources, which generally make ex cathedra, qualitative statements on rickets frequency to, in t...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2017.10.011
更新日期:2018-12-01 00:00:00
abstract::A skeleton excavated from the Blossom Mound (CA-SJO-68), a Late Holocene (4350-2980 BP) site located in the northern San Joaquin Valley of California, exhibits evidence of unusual craniofacial and postcranial features consistent with endocrine disease. Burial 37, an adult male approximately 30-40 years of age, shows p...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.11.003
更新日期:2014-03-01 00:00:00
abstract::Survival of an adult male (M9) with juvenile-onset quadriplegia in Neolithic Vietnam indicates provision of continuous care from his community, and adds to the growing literature documenting survival of disabled individuals in prehistory. Although the role of care-giving in achieving survival is occasionally acknowled...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2011.02.003
更新日期:2011-03-01 00:00:00
abstract::During recent years, the presence of linear ridges or islands of bone ('buttresses') on the anterior aspect of sheep metatarsals has assumed increased visibility in zooarchaeological studies. Although a number of causes have been suggested, the etiology and pathogenesis of this condition has remained unresolved. In th...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2011.02.006
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:This study examines the evidence of three skeletal markers of childhood health that leave permanent observable changes in the adult skeleton during two climate events, the Medieval Warm Period (MWP) and the Little Ice Age (LIA) that occurred in the medieval period (1050-1536 CE). MATERIAL:A total of 241 adul...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.ijpp.2019.09.003
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:This case study describes a perimortem hip fracture in a documented individual from the Robert J. Terry Skeletal Collection. The purpose of this paper is to comprehend how co-occurring conditions contributed to fracture risk and to understand the effect of the injury on this individual. MATERIALS AND METHODS...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.03.004
更新日期:2020-09-01 00:00:00
abstract::Over recent decades histology has increasingly been used as a diagnostic tool in human dry bone palaeopathology. Still, the use of histology in human dry bone is associated with various problems, including a lack of pathognomonic histomorphology and a need for more experimental data. Consequently, the value of histolo...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.03.004
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Paleopathological evidence of cancer from past populations is rare, especially outside of Europe and North Africa. This study expands upon the current temporal and spatial distribution of cancer by presenting a probable case of multiple myeloma from Bronze Age China. MATERIAL:The human skeletal remains of an...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2020.10.003
更新日期:2020-12-01 00:00:00
abstract::A case of potentially dedifferentiated parosteal osteosarcoma was found in the proximal humerus of an adult female buried in the late Anglo-Saxon cemetery of Cherry Hinton, Cambridgeshire, UK. Key features include a large, dense, lobulated mass attached to the medial metaphysis of the proximal humerus by a broad-based...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2016.12.001
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:This work provides a detailed description and differential diagnosis of a Pleistocene cave bear (Ursus spelaeus). MATERIALS:The specimen was recovered at the Cueva de Guantes archaeo- paleontological site, located in the North of the Iberian Peninsula and dated to more than 30k yr BP. METHODS:The study was ...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2018.10.010
更新日期:2019-03-01 00:00:00
abstract::The paper presents a post-mortem examination performed on an adult male from the town of Radom in central Poland. The calotte of this individual had been surgically opened after death with a saw. Based on the archaeological context, this was most probably a Radom resident. The stratigraphy, archaeological artefacts an...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2013.06.002
更新日期:2013-12-01 00:00:00
abstract::The Neolithic colonisation of the Pacific islands was one of the most challenging migration events in human history. The regions east of the Solomon Islands were colonised relatively recently by a people known as the Lapita. The Lapita brought with them a 'transported landscape' of domesticated plants and animals that...
journal_title:International journal of paleopathology
pub_type: 杂志文章
doi:10.1016/j.ijpp.2014.03.001
更新日期:2014-06-01 00:00:00
abstract::This article serves as an introduction to the International Journal of Paleopathology's special issue, Paleo-oncology: Taking Stock and Moving Forward. Reflecting the goals of the special issue, this paper has been designed to provide an overview of the current state of paleo-oncology, to introduce new and innovative ...
journal_title:International journal of paleopathology
pub_type: 历史文章
doi:10.1016/j.ijpp.2018.02.001
更新日期:2018-06-01 00:00:00
abstract::Archaeozoology provides bones, which quite regularly present traces of fractures. These fractures are more or less at an advanced level of healing and bear witness to traumas or pathologies. These cases of palaeopathology are not always the subject of publications, which further restricts our knowledge about them. Thi...
journal_title:International journal of paleopathology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijpp.2018.07.004
更新日期:2018-09-01 00:00:00